RESUMO

Although Chikungunya infection is emerging as an important public health problem in many countries, it is not regarded as a life-threatening disease. Information dealing with fatal cases is scarce. We herein describe three patients with Chickungunya infection who presented with multiple organ failure and died within 24h of admission. Two cases had positive anti-dengue IgM, but dengue coinfection was rejected based on the clinical features and results of real-time reverse transcription polymerase chain reaction. These cases illustrate the challenges of the diagnosis and management of severe Chikungunya infection.

Assuntos

Febre de Chikungunya/diagnóstico , Febre de Chikungunya/terapia , Vírus Chikungunya/patogenicidade , Insuficiência de Múltiplos Órgãos/virologia , Idoso , Anticorpos Antivirais/sangue , Febre de Chikungunya/virologia , Vírus Chikungunya/genética , Coinfecção , Colômbia , Vírus da Dengue/imunologia , Evolução Fatal , Feminino , Hospitalização , Humanos , Masculino , Reação em Cadeia da Polimerase em Tempo Real