RESUMO

Plasma prednisolone levels have been measured hourly in children receiving a single dose of oral prednisone. Peak prednisolone levels occurred one to two hours after ingestion; half-life studies gave a mean value of 132 minutes in most children. Some children had marked variability in absorption and metabolism of prednisone. Somatomedin activity and cell-mediated immunity were inhibited by plasma prednisolone values which were achieved by single doses of prednisone of 0.5 mg/kg or higher. Monitoring prednisolone levels may be of value in identifying those children who accumulate excessively high levels on moderate dosage regimens.

Assuntos

Prednisolona/sangue , Administração Oral , Adolescente , Hiperfunção Adrenocortical/tratamento farmacológico , Asma/tratamento farmacológico , Disponibilidade Biológica , Criança , Pré-Escolar , Doença de Crohn/tratamento farmacológico , Dermatomiosite/tratamento farmacológico , Feminino , Meia-Vida , Humanos , Imunidade Celular/efeitos dos fármacos , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Masculino , Síndrome Nefrótica/tratamento farmacológico , Prednisolona/administração & dosagem , Prednisolona/metabolismo , Prednisolona/uso terapêutico , Somatomedinas/sangue