RESUMO
A very young male infant with Omenn's syndrome had acquired hypothyroidism that was most likely caused by autoimmune thyroiditis. The hypothyroidism appeared at 3 months of age. These 2 rare conditions have not previously been reported occurring together. This case suggests that autoimmune thyroiditis may be another abnormal finding in Omenn's syndrome.
Assuntos
Sarcoma Histiocítico/complicações , Hipotireoidismo/etiologia , Seguimentos , Sarcoma Histiocítico/tratamento farmacológico , Humanos , Hipotireoidismo/tratamento farmacológico , Imunossupressores/uso terapêutico , Lactente , Masculino , Tireoidite Autoimune/tratamento farmacológico , Tireoidite Autoimune/etiologia , Tiroxina/uso terapêuticoRESUMO
A patient with hypereosinophilic syndrome simultaneously had generalized myasthenia gravis. Ultrastructural and functional studies demonstrated an increase of the activated hypodense eosinophils. The eosinophilic cationic protein level in plasma and whole blood paralleled the severity of congestive heart failure. A high level of interleukin-5 was detected in both serum and in conditioned medium of T cells by interleukin-2 stimulation before therapy. The findings indicate that both diseases may be associated with a common T-cell abnormality.
Assuntos
Síndrome Hipereosinofílica/complicações , Miastenia Gravis/complicações , Ribonucleases , Proteínas Sanguíneas/análise , Criança , Proteínas Granulares de Eosinófilos , Eosinófilos/ultraestrutura , Feminino , Glucocorticoides/uso terapêutico , Humanos , Síndrome Hipereosinofílica/diagnóstico , Síndrome Hipereosinofílica/tratamento farmacológico , Mediadores da Inflamação/análise , Linfocinas/sangue , Miastenia Gravis/diagnóstico , Miastenia Gravis/tratamento farmacológico , Prednisolona/uso terapêutico , Linfócitos T/imunologiaRESUMO
Thirty-five children with short-stature underwent insulin-loading and sleep tests for assessment of secretion of human growth hormone. Correlations between the levels of human growth hormone in the serum and urine during the tests were examined to elucidate the clinical significance of urinary human growth hormone levels in short children. The concentration and total amount of human growth hormone in the urine correlated significantly with the peak concentration of serum human growth hormone (r = 0.81, p less than 0.001 and r = 0.80, p less than 0.001, respectively) and the integrated concentration of human growth hormone (r = 0.85, p less than 0.001 and r = 0.85, p less than 0.001, respectively) in the insulin-loading test. The concentration and total amount of human growth hormone in the morning urine also correlated significantly with the peak concentration of serum human growth hormone (r = 0.80, p less than 0.001 and r = 0.70, p less than 0.001, respectively) and the integrated concentration of serum human growth hormone (r = 0.80, p less than 0.001 and r = 0.72, p less than 0.001, respectively) in the sleep test. The concentration or total amount of human growth hormone in the urine differed significantly among children with human growth hormone deficiency, those with nonendocrine short stature, and those with normal stature (p less than 0.05). These data suggest that measurement of human growth hormone in the urine may be used to assess secretion of human growth hormone, serving as a screening test for human growth hormone deficiency in children.