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OBJECTIVES: to describe the profile of older adults who access the internet to search for health information and identify the factors that can influence older adults' decisions about their health based on information collected online. METHODS: 391 older adults answered an online questionnaire regarding habits and satisfaction with information about health collected on the internet. Data processing involved Logistic Regression. RESULTS: higher education reduces by 44% the likelihood of an older adult following the health recommendations on internet sites. However, social activities and self-perceived health increase the possibility of following the recommendations by 83% and 71%, respectively. The belief that the internet promotes healthy habits increases by 29.2 times the probability of an older adult following the advice. FINAL CONSIDERATIONS: knowing the profile of older adults who use the Internet can help professionals formulate public policies and build good information platforms on health and well-being.

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ABSTRACT Objectives: to describe the profile of older adults who access the internet to search for health information and identify the factors that can influence older adults' decisions about their health based on information collected online. Methods: 391 older adults answered an online questionnaire regarding habits and satisfaction with information about health collected on the internet. Data processing involved Logistic Regression. Results: higher education reduces by 44% the likelihood of an older adult following the health recommendations on internet sites. However, social activities and self-perceived health increase the possibility of following the recommendations by 83% and 71%, respectively. The belief that the internet promotes healthy habits increases by 29.2 times the probability of an older adult following the advice. Final Considerations: knowing the profile of older adults who use the Internet can help professionals formulate public policies and build good information platforms on health and well-being.

RESUMO Objetivos: descrever o perfil dos idosos que acessam a internet para buscar informações sobre saúde e identificar os fatores que podem influenciar as decisões dos idosos sobre sua saúde com base nas informações coletadas online. Métodos: 391 idosos responderam a um questionário online sobre hábitos e satisfação com informações sobre saúde coletadas na internet. Processamento dos dados envolveu regressão logística. Resultados: ensino superior reduz em 44% a probabilidade de idosos seguirem recomendações de saúde em sites da internet. Porém, atividades sociais e autopercepção de saúde aumentam a possibilidade de seguir as recomendações em 83% e 71%, respectivamente. A crença de que a internet promove hábitos saudáveis aumenta em 29,2 vezes a probabilidade de idosos seguirem os conselhos. Considerações Finais: conhecer o perfil dos idosos que utilizam a internet pode auxiliar os profissionais na formulação de políticas públicas e na construção de boas plataformas de informação sobre saúde e bem-estar.

RESUMEN Objetivos: describir el perfil de los ancianos que acceden a internet para buscar información de salud e identificar los factores que pueden influir en las decisiones de los ancianos sobre su salud a partir de la información recopilada en línea. Métodos: 391 ancianos respondieron a un cuestionario online sobre hábitos y satisfacción con la información de salud recogida en internet. El procesamiento de datos implicó regresión logística. Resultados: la educación superior reduce en un 44% la probabilidad de que un anciano siga las recomendaciones de salud en los sitios web. Sin embargo, las actividades sociales y la salud autopercibida aumentan la posibilidad de seguir las recomendaciones en un 83% y un 71%, respectivamente. La creencia de que internet promueve hábitos saludables aumenta 29,2 veces la probabilidad de que un anciano siga un consejo. Consideraciones Finales: conocer el perfil de los ancianos que utilizan internet puede ayudar a los profesionales a formular políticas públicas y construir buenas plataformas de información sobre salud y bienestar.

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PURPOSE: To evaluate local and systemic effects of 24-hour fasting in liver ischemia and reperfusion injury. METHODS: Twenty-one adult male Wistar rats (330-390 g) were submitted to 60 minutes of hepatic ischemia followed by 24 hours of reperfusion. Before the day of the experiment, the animals fasted, but free access to water was allowed. Two groups were constituted: Control: non-fasted, that is, feeding ad libitum before surgical procedure; Fasting: rats underwent previous fasting of 24 hours. Hepatic ischemia was performed using vascular clamp in hepatic pedicle. At 24 hours after liver reperfusion, blood and tissue samples were collected. To analysis, liver lobes submitted to ischemia was identified as ischemic liver and paracaval non-ischemic lobes as non-ischemic liver. We evaluated: malondialdehyde levels, hepatocellular function (alanine aminotransferase, aspartate aminotransferase activities, and both ratio), cytokines (interleukins-6, -10, and tumor necrosis factor-alpha), hepatic ischemia and reperfusion injury (histology). RESULTS: Malondialdehyde measured in non-ischemic and ischemic liver samples, hepatocellular function and cytokines were comparable between groups. Histological findings were distinct in three regions evaluated. Microvesicular steatosis was comparable between 24-hour fasting and non-fasted control groups in periportal region of hepatic lobe. In contrast, steatosis was more pronounced in zones 2 and 3 of ischemic liver samples of fasting compared to control groups. CONCLUSIONS: These data indicates that fasting does not protect, but it can be also detrimental to liver submitted to ischemia/reperfusion damage. At that time, using long fasting before liver surgery in the real world may be contraindicated.

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BACKGROUND: The effects of hernia repair on testicular function remain uncertain, regardless of the technique used. Studies that analyze testicular volume and flow after hernia repair or hormonal measurements are scarce and show contradictory results. This study aimed to evaluate the impact of bilateral inguinal hernia repair on male fertility in surgical patients in whom the Lichtenstein and laparoscopic transabdominal preperitoneal (TAPP) techniques were used. METHODS: A randomized clinical trial comparing open (Lichtenstein) versus laparoscopic (TAPP) hernia repair using polypropylene mesh was performed in 48 adult patients (20 to 60 years old) with primary bilateral inguinal hernia. Patients were evaluated preoperatively and 90 and 180 postoperative (PO) days. Sex hormones (Testosterone, FSH, LH and SHGB) analysis, testicular ultrasonography, semen quality sexual activity changes and quality of life (QoL) were performed. Postoperative pain was evaluated using the visual analog scale (VAS). RESULTS: Thirty-seven patients with aged of 44 ± 11 years were included, 19 operated on Lichtenstein and 18 operated on TAPP. The surgical time was similar between techniques. The pain was greater in the Lichtenstein group on the 7th PO day. The biochemical and hormonal analyses, testicular ultrasonography (Doppler, testicular volume, and morphological findings) and sperm quality were similar between groups. However, the sperm morphology was better in the Lichtenstein group after 180 days (p < 0.05 vs. preoperative) and two patients who underwent Lichtenstein hernia repair had oligospermia after 180 days. The QoL evaluation showed a significant improvement after surgery in the following domains: physical function, role emotional, bodily pain and general health (p < 0.05). On comparison of Lichtenstein vs. TAPP none of the domains showed statistically significant differences. No patient reported sexual changes. CONCLUSION: Bilateral inguinal hernia repair with polypropylene mesh, whether using Lichtenstein or TAPP, does not impair male fertility in terms of long-term outcomes. TRIAL REGISTRATION: Approved by the Ethics Committee for the Analysis of Research Projects (CAPPesq) of the HC/FMUSP, Number 2.974.457, in June 2015, Registered on Plataforma Brasil in October 2015 under Protocol 45535015.4.0000.0068. Registered on Clinicaltrials.gov, NCT05799742. Enrollment of the first subject in January 2016.

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PURPOSE: To evaluate effect of N-acetylcysteine (NAC) associated with Ringer lactate or hypertonic saline in inflammation and bacterial translocation on experimental intestinal obstruction (IO). METHODS: Wistar rats was subjected to IO. Six or 24 hours after, rats were subjected to enterectomy and fluid resuscitation: IO, RL (subjected to the same procedures but with fluid resuscitation using Ringer's lactate solution); RLNAC (added NAC to Ringer's solution); and HSNAC (surgical procedure + fluid reposition with 7.5% hypertonic saline and NAC). After 24 h, tissues were collected to cytokines, bacterial translocation, and histological assessments. RESULTS: In kidney, interleukin-1beta (IL-1beta) was lower in the groups with fluid resuscitation compared to IO group. The RLNAC showed lower levels compared to the RL. Interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), and (IFN-gamma) were lower in the treatment groups than in IO. In lung, IL-1beta and IL-6 were lower in RLNAC compared to IO. IL-10 was lower in RL, RLNAC and HSNAC compared to IO. TNF-alpha was higher in HSNAC compared to both RL and RLNAC. Bacterial translocation was observed in all animals of IO group. In kidneys, inflammation and congestion degrees were lower in HSNAC compared to RL. In lungs, inflammation levels were higher in RLNAC compared with the sham group. CONCLUSIONS: The data indicates that NAC associated with RL can promote a decrease in the inflammatory process in the kidneys and lungs in rats, following intestinal obstruction and ischemia in rats.

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Purpose: To evaluate local and systemic effects of 24-hour fasting in liver ischemia and reperfusion injury. Methods: Twenty-one adult male Wistar rats (330-390 g) were submitted to 60 minutes of hepatic ischemia followed by 24 hours of reperfusion. Before the day of the experiment, the animals fasted, but free access to water was allowed. Two groups were constituted: Control: non-fasted, that is, feeding ad libitum before surgical procedure; Fasting: rats underwent previous fasting of 24 hours. Hepatic ischemia was performed using vascular clamp in hepatic pedicle. At 24 hours after liver reperfusion, blood and tissue samples were collected. To analysis, liver lobes submitted to ischemia was identified as ischemic liver and paracaval non-ischemic lobes as non-ischemic liver. We evaluated: malondialdehyde levels, hepatocellular function (alanine aminotransferase, aspartate aminotransferase activities, and both ratio), cytokines (interleukins-6, -10, and tumor necrosis factor-alpha), hepatic ischemia and reperfusion injury (histology). Results: Malondialdehyde measured in non-ischemic and ischemic liver samples, hepatocellular function and cytokines were comparable between groups. Histological findings were distinct in three regions evaluated. Microvesicular steatosis was comparable between 24-hour fasting and non-fasted control groups in periportal region of hepatic lobe. In contrast, steatosis was more pronounced in zones 2 and 3 of ischemic liver samples of fasting compared to control groups. Conclusions: These data indicates that fasting does not protect, but it can be also detrimental to liver submitted to ischemia/reperfusion damage. At that time, using long fasting before liver surgery in the real world may be contraindicated.

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Objetivo: Analisar a qualidade de vida (QV) da população com sobrepeso referenciada ou assistida pela Atenção Básica de Saúde (ABS), evidenciando fatores clínicos e sociodemográficos associados aos aspectos da QV. Métodos: Estudo transversal analítico de caráter epidemiológico, desenvolvido em 2017-2020, em um município de Minas Gerais, Brasil, com 269 pessoas com sobrepeso e índice de massa corpórea (IMC) igual ou acima de 25 kg/m². Aplicaram-se instrumentos para avaliação da QV, contendo dados sociodemográficos, ansiedade, depressão, compulsão alimentar periódica e percepção da autoimagem. Utilizou-se análise univariada, regressão linear simples e múltipla com p<0,05. Resultados: Encontrou-se 74,3% (n=200) do sexo feminino, idade média de 39,43 ± 14,46 anos, 55% (n=149) obesidade moderada. 50% (n=134) apresentaram sintomas de ansiedade, 42,4% (n=114) sintomas depressivos, 20% (n=54) com compulsão alimentar e 32% (n=86) consideraram comprometimento negativo na sua autoimagem. 62,1% (n=167) apresentaram insuficiência na dimensão vitalidade. Quanto aos aspectos de correlação, IMC elevado, uso de medicação, aumento da idade, estado civil viúvo, presença de sintomas de ansiedade, depressão, compulsão alimentar e ausência de atividade física apresentaram diminuição em dimensões da QV. Conclusão: O estudo apontou que, entre as oito dimensões analisadas, apenas a dimensão "vitalidade" apresentou dados significativamente baixos entre os participantes, sendo possível identificar variáveis sociodemográficas que se correlacionaram, tendendo a diminuir aspectos ou dimensões da qualidade de vida: obesidade grave, fazer uso de medicação, apresentar estado civil viúvo, não realizar atividades físicas regularmente, apresentar sintomas de ansiedade, depressão e compulsão alimentar periódica em nível grave.

Objective: To analyze the Quality of Life (QoL) of the overweight population referred to or assisted by Primary Health Care (PHC), evidencing clinical and sociodemographic factors associated with aspects of QoL. Methods: Analytical cross-sectional epidemiological study, carried out in 2017-2020, in a municipality of Minas Gerais, Brazil, with 269 overweight people with a body mass index (BMI) equal to or above 25 kg/m². Instruments were applied to assess QoL, sociodemographic data, anxiety, depression, binge eating, and self-image perception. Simple and multiple linear regression were used. Results: 74.3% (n=200) were female, mean age of 39.43 ± 14.46 years, 55% (n=149) were moderately obese. 50% (n=134) had symptoms of anxiety, 42.4% (n=114) had depressive symptoms, 20% (n=54) had binge eating and 32% (n=86) considered their self-image to be negatively affected. 62.1% (n=167) showed insufficiency in the vitality dimension. As for the correlation aspects, high BMI, medication use, increasing age, widowed marital status, symptoms of anxiety, depression, binge eating, and lack of physical activity showed a decrease in QOL dimensions. Conclusion: The study showed that among the eight dimensions analyzed, only the "vitality" dimension presented significantly low data among the participants, making it possible to identify sociodemographic variables that were correlated, tending to decrease aspects or dimensions of quality of life: severe obesity, using of medication, being widowed, not performing physical activities regularly, presenting symptoms of anxiety, depression, and binge eating at a severe level.

Objetivo: Analizar la calidad de vida (CV) de la población con sobrepeso referenciada o asistida por la Atención Primaria de Salud (APS), evidenciando factores clínicos y sociodemográficos asociados a los aspectos de la CV. Métodos: Estudio transversal analítico de carácter epidemiológico, desarrollado en 2017-2020, en un municipio de Minas Gerais, Brasil, con 269 personas consobrepeso e índice de masa corporal (IMC) igual o superior a 25kg/m². Fueron aplicados instrumentos para evaluación de la CV, conteniendo datos sociodemográficos, ansiedad, depresión, trastorno de hiperfagia compulsiva y percepción de autoimagen. Fue utilizado análisis univariado, regresión linear simple y múltiple con p<0,05. Resultados: Se encontró 74,3% (n=200) del sexo femenino, edad média de 39,43 ± 14,46 años, 55% (n=149) obesidad moderada. 50% (n=134) presentaron síntomas de ansiedad, 42,4% (n=114) síntomas depresivos, 20% (n=54) con trastorno de hiperfagia compulsiva e 32% (n=86) consideraron comprometimiento negativo en su autoimagen. 62,1% (n=167) presentaron insuficiencia en la dimensión vitalidad. Cuanto a los aspectos de correlación, IMC alto, uso de medicación, aumento de la edad, estado civil viudo, presencia de síntomas de ansiedad, depresión, trastorno de hiperfagia compulsiva y ausencia de actividad física presentaron disminución en dimensiones de la CV. Conclusión: El estudio indicó que, entre las ocho dimensiones analizadas, solamente la dimensión "vitalidad" presentó datos significativamente bajos entre los participantes, posibilitando la identificación de variables sociodemográficas que se correlacionaron, tendiendo a disminuir aspectos o dimensiones de la calidad de vida: obesidad grave, uso de medicación, presentar estado civil viudo, no realizar actividades físicas regularmente, presentar síntomas de ansiedad, depresión y trastornode hiperfagia compulsiva en nivel grave.

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Purpose: To evaluate effect of N-acetylcysteine (NAC) associated with Ringer lactate or hypertonic saline in inflammation and bacterial translocation on experimental intestinal obstruction (IO). Methods: Wistar rats was subjected to IO. Six or 24 hours after, rats were subjected to enterectomy and fluid resuscitation: IO, RL (subjected to the same procedures but with fluid resuscitation using Ringer's lactate solution); RLNAC (added NAC to Ringer's solution); and HSNAC (surgical procedure + fluid reposition with 7.5% hypertonic saline and NAC). After 24 h, tissues were collected to cytokines, bacterial translocation, and histological assessments. Results: In kidney, interleukin-1beta (IL-1beta) was lower in the groups with fluid resuscitation compared to IO group. The RLNAC showed lower levels compared to the RL. Interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-alpha), and (IFN-gamma) were lower in the treatment groups than in IO. In lung, IL-1beta and IL-6 were lower in RLNAC compared to IO. IL-10 was lower in RL, RLNAC and HSNAC compared to IO. TNF-alpha was higher in HSNAC compared to both RL and RLNAC. Bacterial translocation was observed in all animals of IO group. In kidneys, inflammation and congestion degrees were lower in HSNAC compared to RL. In lungs, inflammation levels were higher in RLNAC compared with the sham group. Conclusions: The data indicates that NAC associated with RL can promote a decrease in the inflammatory process in the kidneys and lungs in rats, following intestinal obstruction and ischemia in rats.

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OBJECTIVE: To compare the traditional printed form of the Behavioral Regulation in Exercise Questionnaire with a proposed online form in terms of validity, reliability, and applicability. METHODS: A crossover design study was conducted with 157 undergraduate students. Half of the sample answered the printed questionnaire first and then answered the online questionnaire 7 days later, while the other half of the sample did the inverse. Cronbach's alpha was used to analyze the internal consistency of both the online and printed questionnaires. The construct validity was analyzed by confirmatory factor analysis, using a weighted least square mean and adjusted variance estimation and oblique rotation. The quality of the model was tested with fit indices. RESULTS: The confirmatory factor analysis showed the 19-item structure with five factors: χ2 of 230.718; degrees of freedom of 142; χ2/degrees of freedom of 1.625; comparative fit index of 0.978 and root mean square error of approximation of 0.073. All items presented factorial loads above 0.5. There was also excellent consistency between the formats of administration in all dimensions, with Cronbach's alpha values above 0.70. The stability between the formats of administration varied between 0.78 (95%CI: 0.69-0.85) and 0.84 (95%CI: 0.77-0.89), suggesting desirable confidence between both formats of administration. CONCLUSION: The five-factor model of the online Behavioral Regulation in Exercise Questionnaire shows internal consistency both in terms of the scale dimensions as well as in terms of the total items.

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ABSTRACT Objective: To compare the traditional printed form of the Behavioral Regulation in Exercise Questionnaire with a proposed online form in terms of validity, reliability, and applicability. Methods: A crossover design study was conducted with 157 undergraduate students. Half of the sample answered the printed questionnaire first and then answered the online questionnaire 7 days later, while the other half of the sample did the inverse. Cronbach's alpha was used to analyze the internal consistency of both the online and printed questionnaires. The construct validity was analyzed by confirmatory factor analysis, using a weighted least square mean and adjusted variance estimation and oblique rotation. The quality of the model was tested with fit indices. Results: The confirmatory factor analysis showed the 19-item structure with five factors: χ2 of 230.718; degrees of freedom of 142; χ2/degrees of freedom of 1.625; comparative fit index of 0.978 and root mean square error of approximation of 0.073. All items presented factorial loads above 0.5. There was also excellent consistency between the formats of administration in all dimensions, with Cronbach's alpha values above 0.70. The stability between the formats of administration varied between 0.78 (95%CI: 0.69-0.85) and 0.84 (95%CI: 0.77-0.89), suggesting desirable confidence between both formats of administration. Conclusion: The five-factor model of the online Behavioral Regulation in Exercise Questionnaire shows internal consistency both in terms of the scale dimensions as well as in terms of the total items.

RESUMO Objetivo: Comparar a forma tradicional impressa do Behavioral Regulation in Exercise Questionnaire com uma proposta de formulário on-line, em termos de validade, confiabilidade e aplicabilidade. Métodos: Estudo de delineamento cruzado (crossover) realizado com 157 estudantes universitários de graduação. Metade da amostra respondeu primeiro ao questionário impresso e, 7 dias depois, ao questionário on-line, enquanto a outra metade da amostra fez o inverso. O coeficiente alfa de Cronbach foi usado para analisar a consistência interna dos questionários on-line e impressos. A validade de construção foi verificada por análise fatorial confirmatória, utilizando-se um estimador de mínimos quadrados ajustados pela média e variância e rotação oblíqua. A qualidade do modelo foi testada com índices de ajuste. Resultados: A análise fatorial confirmatória mostrou a estrutura de 19 itens com cinco fatores: χ2 de 230,718; graus de liberdade de 142; χ2/grau de liberdade de 1,625; índice de ajuste comparativo de 0,978 e raiz do erro quadrático médio de aproximação de 0,073. Todos os itens apresentaram cargas fatoriais acima de 0,5. Também houve excelente consistência entre os formatos de administração em todas as dimensões, com valores de alfa de Cronbach acima de 0,70. A estabilidade entre os formatos de administração variou entre 0,78 (IC95%: 0,69-0,85) e 0,84 (IC95%: 0,77-0,89), sugerindo confiança desejável entre os dois formatos de administração. Conclusão: O modelo de cinco fatores do Behavioral Regulation in Exercise Questionnaire on-line apresenta consistência interna tanto em relação às dimensões da escala quanto em relação ao total de itens.

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