RESUMO
Primary localized cutaneous amyloidosis is a skin-limited amyloidosis that does not involve internal organs. It is clinically subclassified into 3 general categories and some rare variants. However, there is considerable overlap within the classification. Though there are a variety of therapeutic measures, the treatment is often unsatisfactory, particularly when the disease is severe and extensive. We describe a rare case of primary localized cutaneous amyloidosis with lichen and poikiloderma-like lesions that showed an excellent response to systemic acitretin.
Assuntos
Acitretina/uso terapêutico , Amiloidose Familiar/tratamento farmacológico , Ceratolíticos/uso terapêutico , Dermatopatias Genéticas/tratamento farmacológico , Amiloidose Familiar/complicações , Amiloidose Familiar/diagnóstico , Feminino , Humanos , Erupções Liquenoides/complicações , Erupções Liquenoides/tratamento farmacológico , Dermatopatias Genéticas/complicações , Dermatopatias Genéticas/diagnóstico , Resultado do Tratamento , Adulto JovemRESUMO
Abstract: Primary localized cutaneous amyloidosis is a skin-limited amyloidosis that does not involve internal organs. It is clinically subclassified into 3 general categories and some rare variants. However, there is considerable overlap within the classification. Though there are a variety of therapeutic measures, the treatment is often unsatisfactory, particularly when the disease is severe and extensive. We describe a rare case of primary localized cutaneous amyloidosis with lichen and poikiloderma-like lesions that showed an excellent response to systemic acitretin.
Assuntos
Humanos , Feminino , Adulto Jovem , Dermatopatias Genéticas/tratamento farmacológico , Acitretina/uso terapêutico , Amiloidose Familiar/tratamento farmacológico , Ceratolíticos/uso terapêutico , Dermatopatias Genéticas/complicações , Dermatopatias Genéticas/diagnóstico , Resultado do Tratamento , Erupções Liquenoides/complicações , Erupções Liquenoides/tratamento farmacológico , Amiloidose Familiar/complicações , Amiloidose Familiar/diagnósticoRESUMO
PURPOSE: To construct a new biomaterial-small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor, and to evaluate the new biomaterials for the reconstruction of abdominal wall defects. METHODS: Thirty six Sprague-Dawley rats were used in the animal experiments and randomly divided into three groups. The new biomaterial was constructed by combining small intestinal submucosa with gelatin hydrogel for basic fibroblast growth factor release. Abdominal wall defects were created in rats, and repaired using the new biomaterials (group B), compared with small intestinal submucosa (group S) and ULTRAPROTM mesh (group P). Six rats in each group were sacrificed at three and eight weeks postoperatively to examine the gross effects, inflammatory responses, collagen deposition and neovascularization. RESULTS: After implantation, mild adhesion was caused in groups B and S. Group B promoted more neovascularization than group S at three weeks after implantation, and induced significantly more amount of collagen deposition and better collagen organization than groups S and P at eight weeks after implantation. CONCLUSION: Small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor could promote better regeneration and remodeling of host tissues for the reconstruction of abdominal wall defects.
Assuntos
Parede Abdominal/cirurgia , Materiais Biocompatíveis/uso terapêutico , Fator 2 de Crescimento de Fibroblastos/uso terapêutico , Gelatina/uso terapêutico , Hidrogel de Polietilenoglicol-Dimetacrilato/uso terapêutico , Mucosa Intestinal/transplante , Parede Abdominal/patologia , Animais , Colágeno/análise , Imuno-Histoquímica , Intestino Delgado , Teste de Materiais , Distribuição Aleatória , Ratos Sprague-Dawley , Regeneração , Reprodutibilidade dos Testes , Fatores de Tempo , Aderências Teciduais , Resultado do TratamentoRESUMO
To construct a new biomaterial-small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor, and to evaluate the new biomaterials for the reconstruction of abdominal wall defects. Thirty six Sprague-Dawley rats were used in the animal experiments and randomly divided into three groups. The new biomaterial was constructed by combining small intestinal submucosa with gelatin hydrogel for basic fibroblast growth factor release. Abdominal wall defects were created in rats, and repaired using the new biomaterials (group B), compared with small intestinal submucosa (group S) and ULTRAPROTM mesh (group P). Six rats in each group were sacrificed at three and eight weeks postoperatively to examine the gross effects, inflammatory responses, collagen deposition and neovascularization. After implantation, mild adhesion was caused in groups B and S. Group B promoted more neovascularization than group S at three weeks after implantation, and induced significantly more amount of collagen deposition and better collagen organization than groups S and P at eight weeks after implantation. Small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor could promote better regeneration and remodeling of host tissues for the reconstruction of abdominal wall defects.
Assuntos
Animais , Ratos , Fibroblastos , Hidrogéis , Mucosa Intestinal/anatomia & histologia , Parede Abdominal/anatomia & histologia , Ratos/classificaçãoRESUMO
To construct a new biomaterial-small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor, and to evaluate the new biomaterials for the reconstruction of abdominal wall defects. Thirty six Sprague-Dawley rats were used in the animal experiments and randomly divided into three groups. The new biomaterial was constructed by combining small intestinal submucosa with gelatin hydrogel for basic fibroblast growth factor release. Abdominal wall defects were created in rats, and repaired using the new biomaterials (group B), compared with small intestinal submucosa (group S) and ULTRAPROTM mesh (group P). Six rats in each group were sacrificed at three and eight weeks postoperatively to examine the gross effects, inflammatory responses, collagen deposition and neovascularization. After implantation, mild adhesion was caused in groups B and S. Group B promoted more neovascularization than group S at three weeks after implantation, and induced significantly more amount of collagen deposition and better collagen organization than groups S and P at eight weeks after implantation. Small intestinal submucosa coated with gelatin hydrogel incorporating basic fibroblast growth factor could promote better regeneration and remodeling of host tissues for the reconstruction of abdominal wall defects.(AU)
Assuntos
Animais , Ratos , Parede Abdominal/anatomia & histologia , Mucosa Intestinal/anatomia & histologia , Hidrogéis , Fibroblastos , Ratos/classificaçãoRESUMO
Cutaneous Rosai-Dorfman disease is a rare, lymphoproliferative disease. It is benign and self-limited, only involves skin and subcutaneous tissue and typically occurs as histiocyte-rich inflammatory infiltrates, manifesting as erythematous to brown papules, plaques, or nodules, without predilection for site. The authors describe a case of cutaneous Rosai-Dorfman disease in a 72-year-old man who presented erythematous and scaled plaque on the right neck for three months without systemic symptoms. Owing to local involvement, the patient received a surgery to exsect the lesion completely and remained asymptomatic with no signs of recurrence at the 9-month follow up.
Assuntos
Histiocitose Sinusal/patologia , Dermatopatias/patologia , Idoso , Histiocitose Sinusal/cirurgia , Humanos , Masculino , Pescoço/patologia , Pele/patologia , Dermatopatias/cirurgiaRESUMO
Cutaneous Rosai-Dorfman disease is a rare, lymphoproliferative disease. It is benign and self-limited, only involves skin and subcutaneous tissue and typically occurs as histiocyte-rich inflammatory infiltrates, manifesting as erythematous to brown papules, plaques, or nodules, without predilection for site. The authors describe a case of cutaneous Rosai-Dorfman disease in a 72-year-old man who presented erythematous and scaled plaque on the right neck for three months without systemic symptoms. Owing to local involvement, the patient received a surgery to exsect the lesion completely and remained asymptomatic with no signs of recurrence at the 9-month follow up.