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The present review highlights the potential of insect-based proteins to address the growing need for sustainable and secure food systems. The key findings suggest that edible insects offer a viable and environmentally friendly alternative to traditional livestock, requiring significantly less land, water, and feed while emitting lower levels of greenhouse gases. Insect farming can also reduce waste and recycle nutrients, supporting circular economy models. Nutritionally, insects provide high-quality protein, essential amino acids, and beneficial fats, making them valuable to human diets. Despite these benefits, this review emphasizes the need for comprehensive regulatory frameworks to ensure food safety, manage potential allergenicity, and mitigate contamination risks from pathogens and environmental toxins. Additionally, developing innovative processing technologies can enhance the palatability and marketability of insect-based products, promoting consumer acceptance. This review concludes that with appropriate regulatory support and technological advancements, insect-based proteins have the potential to significantly contribute to global food security and sustainability efforts.

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This study explores the influence of hydrocolloid interactions between Guar Gum (GG) and Xanthan Gum (XG) on the stability and release dynamics of essential thyme oil emulsions. We systematically characterized six emulsions with varying GG and XG ratios, employing spray-drying techniques for the encapsulation process. The stability of the emulsions was quantitatively analyzed, revealing a marked decrease in stability rates correlated with higher initial emulsion activity (zero-order kinetic constant r = -0.972). Furthermore, this study demonstrated that emulsions with carefully optimized hydrocolloid ratios could achieve high encapsulation efficiency (74%) and controlled release profiles. Kinetic modeling and diffusion analyses elucidated that increased XG concentrations tend to reduce diffusivity, thereby enhancing emulsion stability. The effective diffusivity of the thyme oil within the emulsion matrix was determined to be within a range of 0.7 to 2.4 × 10-10 m2/s, significantly influencing release kinetics. The Pearson correlation matrix underlined a substantial negative association between emulsion activity and effective diffusivity (r = -0.740), indicating that denser hydrocolloid networks impede oil mobility. The findings conclusively establish that the interplay of GG and XG concentrations is pivotal in dictating the emulsion's physicochemical properties, with denser networks formed by higher XG content leading to slower oil release rates and enhanced stability. This research provides critical insights for the design of encapsulated food and pharmaceutical products, highlighting the imperative of strategic hydrocolloid selection to realize specific functional attributes and performance criteria.

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Bioactive compounds derived from secondary metabolism in animals have refined selectivity and potency for certain biological targets. The superfamily Dendrobatoidea is adapted to the dietary sequestration and secretion of toxic alkaloids, which play a role in several biological activities, and thus serve as a potential source for pharmacological and biotechnological applications. This article constitutes a scoping review to understand the trends in experimental research involving bioactive alkaloids derived from Dendrobatoidea based upon scientometric approaches. Forty-eight (48) publications were found in 30 journals in the period of 60 years, between 1962 and 2022. More than 23 structural classes of alkaloids were cited, with 27.63% for batrachotoxins, 13.64% for pyridinics, with an emphasis on epibatidine, 16.36% for pumiliotoxins, and 11.82% for histrionicotoxins. These tests included in vivo (54.9%), in vitro (39.4%), and in silico simulations (5.6%). Most compounds (54.8%) were isolated from skin extracts, whereas the remainder were obtained through molecular synthesis. Thirteen main biological activities were identified, including acetylcholinesterase inhibitors (27.59%), sodium channel inhibitors (12.07%), cardiac (12.07%), analgesic (8.62%), and neuromuscular effects (8.62%). The substances were cited as being of natural origin in the "Dendrobatidae" family, genus "Phyllobates," "Dendrobates," and seven species: Epipedobates tricolor, Phyllobates aurotaenia, Oophaga histrionica, Oophaga pumilio, Phyllobates terribilis, Epipedobates anthonyi, and Ameerega flavopicta. To date, only a few biological activities have been experimentally tested; hence, further studies on the bioprospecting of animal compounds and ecological approaches are needed.

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RESUMO Objetivo analisar a percepção de estudantes de enfermagem sobre sua formação profissional para atenção à saúde de pessoas LGBTQIA+. Métodos estudo qualitativo, realizado com 19 estudantes de enfermagem por meio de entrevistas semiestruturadas. Os dados foram processados e trabalhados por meio de análise lexical com utilização do software IRaMuTeQ®. Resultados o corpus textual deu origem a duas categorias: formação profissional de enfermagem sobre saúde de pessoas LGBTQIA+ (subdividida em: espaços curriculares que abordam a saúde de pessoas LGBTQIA+ e Déficits formativos para atenção à saúde de pessoas LGBTQIA+) e Espaços extracurriculares de formação profissional sobre saúde de pessoas LGBTQIA+ (subdividida em: aprendizagem informal e extracurricular sobre saúde de pessoas LGBTQIA+ e Contexto do trabalho e a autonomia na aprendizagem sobre saúde LGBTQIA+). Conclusão a abordagem da saúde de pessoas LGBTQIA+ na formação de enfermeiros(as) necessita expandir para além de aulas pontuais, o que demanda a criação de espaços dentro das matrizes curriculares que abordem as especificidades requeridas por essa população, sem, no entanto, relega-las às atividades extracurriculares. Contribuições para a prática: problematização da formação de enfermeiros(as) para a atenção à saúde de pessoas LGBTQIA+.

ABSTRACT Objective to analyze nursing students' perceptions about their professional training for health care of LGBTQIA+ people. Methods qualitative study, conducted with 19 nursing students through semi-structured interviews. Data were processed and worked through lexical analysis using IRaMuTeQ®software. Results the textual corpus gave rise to two categories: professional nursing training on health of LGBTQIA+ people (subdivided into: curricular spaces addressing health of LGBTQIA+ people and Formative deficits for health care of LGBTQIA+ people) and Extracurricular spaces of professional training on health of LGBTQIA+ people (subdivided into: informal and extracurricular learning on health of LGBTQIA+ people and Work context and autonomy in learning about LGBTQIA+ health). Conclusion addressing the health of LGBTQIA+ people in the training of nurses needs to expand beyond specific classes, which demands the creation of spaces within the curricular matrices that address the specificities required by this population, without, however, relegating them to extracurricular activities. Contributions to practice problematization of the training of nurses for the health care of LGBTQIA+ people.

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Biopolishing is a textile process that uses cellulases to improve the pilling resistance of fabrics. Although the process improves the pilling resistance, softness and color brightness of fabrics, it causes a significant loss of tensile strength in treated fabrics. The present work studied the use of cellulase immobilized on kaolin by adsorption and covalent bonding in biopolishing to get around this problem. The cellulase immobilization has been reported as promising alternative to overcome the inconvenient of biopolishing, but it has been very poorly explored. The results showed that cellulase immobilized by both covalent bonding and adsorption methods provided to the knitted fabric similar or superior pilling resistance to free cellulase, but with greater tensile strength. Immobilization also allowed for efficient recovery and reuse of the enzyme. The present work is a relevant contribution to the literature, since, as far as we know, it is the first work that shows it is possible to minimize the loss of tensile strength and also reuse the immobilized enzyme, giving a better-quality product and also contribution to reducing the cost of the polishing step.

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In the current research, endoglucanase, one of the enzymes of the cellulolytic complex, was immobilized on kaolin by two different techniques, adsorption, and covalent bonding. A comparative study was conducted between free, adsorbed, and covalently immobilized endoglucanase. For the covalent bonding, the kaolin particles were functionalized with 3-aminopropyltriethoxysilane (APTES) and activated with glutaraldehyde. Immobilization by adsorption was performed using the kaolin without any treatment. Recovered activities after the endoglucanase immobilization by adsorption and covalent bonding were found to be 60 ± 2.5 and 65 ± 3.5%, respectively. The studies of optima pH and temperature, as well as thermal stability, showed that the catalytic characteristic of the enzyme was maintained after the immobilization by both adsorption and covalent bonding. Even after 8 cycles of use, the endoglucanase immobilized by the two techniques retained about 86% of its initial activity. The results showed that the adsorption was as effective as covalent bonding for the immobilization of endoglucanase on kaolin. However, the adsorption technique seems to have a greater potential for use in future studies, as it is simpler, cheaper, and faster than covalent immobilization. Therefore, in this work it was demonstrated that endoglucanases can be immobilized efficiently on kaolin through a very simple immobilization protocol, offering a promising strategy for performing repeated enzymatic hydrolysis reactions.

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Resumo Objetivo compreender a experiência de mães de crianças traqueostomizadas, entre 0 e 24 meses de idade, que retomaram o aleitamento materno com o uso de válvula de deglutição Passy-Muir®. Método pesquisa descritiva, de natureza qualitativa, com 11 mães de crianças traqueostomizadas que adaptaram a válvula de deglutição Passy-Muir®, acompanhadas em um centro de reabilitação e fonoaudiologia, mediante entrevistas semiestruturadas, nos meses de junho a agosto de 2017. A análise foi fundamentada nos pressupostos da análise de conteúdo temática. Resultados na experiência das mães, após a traqueostomia da criança, o uso da válvula de deglutição Passy-Muir® minimizou as dificuldades no aleitamento materno. Superado o processo de adaptação da válvula, foram percebidos seus benefícios. São descritos os sentimentos das mães nesse processo, suas expectativas quanto ao uso do dispositivo e o prazer e plenitude para a mulher no retorno do aleitamento materno. Conclusões e implicações para a prática observaram-se segurança ao aleitar, menor produção de secreção, reduções no número de aspirações de vias áreas, melhora no padrão respiratório, vocalizações (balbucios e choro), melhora na qualidade do sono da criança. Novas pesquisas que abordem o aleitamento materno de crianças traqueostomizadas são necessárias para aprofundar conhecimentos nesta área.

Resumen Objetivo comprender la experiencia de las madres de niños traqueostomizados, entre 0 y 24 meses de edad, que reanudaron la lactancia materna con el uso de la válvula de deglución Passy-Muir®. Método estudio descriptivo, de carácter cualitativo, en el que participaron 11 madres de niños traqueostomizados, mediante seguimiento en un centro de rehabilitación y logopedia, que adaptó la válvula de deglución Passy-Muir®, con entrevistas semiestructuradas, de junio a agosto de 2017. El análisis se basó en los presupuestos del análisis de contenido temático. Resultados en la experiencia de las madres, después de la traqueotomía del niño, el uso de la válvula de deglución Passy-Muir® minimizó las dificultades en la lactancia. Una vez superado el proceso de adaptación de la válvula, se hicieron realidad sus beneficios. Se describen los sentimientos de las madres en el proceso de adaptación de la válvula, sus expectativas con el uso de la válvula y el placer y plenitud para la mujer en el regreso de la lactancia. Conclusiones e implicaciones para la práctica Se observó seguridad durante la lactancia, reducción de la producción de secreciones, reducciones diarias en el número de aspiraciones de las vías aéreas, advirtiéndose mejoras en el patrón respiratorio, vocalizaciones (balbuceo y llanto) y en la calidad del sueño del niño. Es necesita más investigación que aborde la lactancia materna de niños traqueostomizados, solidificando los conocimientos en esta área.

Abstract Objective To understand the experience of mothers of tracheostomized children between 0 and 24 months old, who resumed breastfeeding with the use of the Passy-Muir® deglutition valve. Method A descriptive study with a qualitative approach and semistructured interviews conducted from June to August 2017 in which the participants were 11 mothers of tracheostomized children, by follow-up in a rehabilitation and logopedia center, which adapted the Passy-Muir® deglutition valve. The analysis was based on the assumptions of thematic content analysis. Results the mothers' experience, after the child's tracheostomy, the use of the Passy-Muir® swallowing valve minimized the difficulties in breastfeeding. Once the valve adaptation process was overcome, its benefits were realized. The mothers' feelings in the process of adapting the valve are described, their expectations with the use of the valve and pleasure and fullness for the woman in the return of breastfeeding. Conclusions and implications for practice Safety during breastfeeding, reduction in the production of secretions, and reductions in the number of airway aspirations were observed, noticing improvements in the respiratory pattern, in the vocalizations (mumbling and crying), and in the child's sleep quality. Further research is needed to address breastfeeding of tracheostomized children to deepen knowledge in this area.

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This is a report on an outbreak of cattle poisoning by Stryphnodendron rotundifolium var. villosum (Benth.) Scalon in the state of Goiás in Brazil. In a herd of 80 cattle that consumed the mature fruit of this plant that was present in their pasture, 12 animals fell ill and died. The clinical signs that they presented were apathy, progressive weight loss, reeling, bristling, and dry stools containing seeds. The main necropsy findings were jaundice, an increased lobular pattern and orange coloration in their liver, enlarged kidneys with yellowish medullae, and pre-stomachs containing fruit peels and seeds. A histopathological examination revealed vacuolar degeneration and necrosis in the liver and kidneys and vacuolar degeneration in the rumen, omasum, reticulum, and intestine. The diagnosis of poisoning by S. rotundifolium var. villosum was based on epidemiological data, clinical findings, and pathological changes. Our results can aid in the differentiation between poisoning by S. rotundifolium var. villosum and poisoning by other toxic plants that are of interest to lifestock.(AU)

Relata-se um surto de intoxicação em bovinos por Stryphnodendron rotundifolium var. villosum (Benth.) Scalon no estado de Goiás, Brasil. De um rebanho composto por 80 bovinos, os quais consumiram frutos maduros da planta presente na pastagem, 12 animais adoeceram e morreram. Os sinais clínicos apresentados foram apatia, emagrecimento progressivo, andar cambaleante, pelo eriçado e fezes secas contendo sementes. Os principais achados de necropsia foram icterícia, fígado com padrão lobular e coloração alaranjada, rins aumentados e com amarelamento da medular e pré-estômagos com presença de cascas e sementes do fruto. Ao exame histopatológico, notou-se degeneração vacuolar e necrose no fígado e rins e degeneração vacuolar no rúmen, omaso, retículo e intestino. O diagnóstico da intoxicação por S. rotundifolium var. villosum baseou-se nos dados epidemiológicos, nos achados clínicos e nas alterações patológicas. Nossos resultados podem auxiliar na diferenciação entre a intoxicação por S. rotundifolium var. villosum e a intoxicação por outras plantas tóxicas de interesse pecuário.(AU)

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This is a report on an outbreak of cattle poisoning by Stryphnodendron rotundifolium var. villosum (Benth.) Scalon in the state of Goiás in Brazil. In a herd of 80 cattle that consumed the mature fruit of this plant that was present in their pasture, 12 animals fell ill and died. The clinical signs that they presented were apathy, progressive weight loss, reeling, bristling, and dry stools containing seeds. The main necropsy findings were jaundice, an increased lobular pattern and orange coloration in their liver, enlarged kidneys with yellowish medullae, and pre-stomachs containing fruit peels and seeds. A histopathological examination revealed vacuolar degeneration and necrosis in the liver and kidneys and vacuolar degeneration in the rumen, omasum, reticulum, and intestine. The diagnosis of poisoning by S. rotundifolium var. villosum was based on epidemiological data, clinical findings, and pathological changes. Our results can aid in the differentiation between poisoning by S. rotundifolium var. villosum and poisoning by other toxic plants that are of interest to lifestock.(AU)

Relata-se um surto de intoxicação em bovinos por Stryphnodendron rotundifolium var. villosum (Benth.) Scalon no estado de Goiás, Brasil. De um rebanho composto por 80 bovinos, os quais consumiram frutos maduros da planta presente na pastagem, 12 animais adoeceram e morreram. Os sinais clínicos apresentados foram apatia, emagrecimento progressivo, andar cambaleante, pelo eriçado e fezes secas contendo sementes. Os principais achados de necropsia foram icterícia, fígado com padrão lobular e coloração alaranjada, rins aumentados e com amarelamento da medular e pré-estômagos com presença de cascas e sementes do fruto. Ao exame histopatológico, notou-se degeneração vacuolar e necrose no fígado e rins e degeneração vacuolar no rúmen, omaso, retículo e intestino. O diagnóstico da intoxicação por S. rotundifolium var. villosum baseou-se nos dados epidemiológicos, nos achados clínicos e nas alterações patológicas. Nossos resultados podem auxiliar na diferenciação entre a intoxicação por S. rotundifolium var. villosum e a intoxicação por outras plantas tóxicas de interesse pecuário.(AU)

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INTRODUCTION: Leishmaniasis, a disease caused by a parasite endemic to large areas of tropical and subtropical countries, is a growing public health problem. METHODS: Male BALB/c mice were infected with Leishmania amazonensis and treated with extracts isolated from Annona mucosa. RESULTS: Treated groups had significantly reduced footpad swelling. The group treated intraperitoneally with hexane extract showed footpad swelling similar to groups treated with Pentamidine® and Glucantime®. Groups treated with dichloromethane extract and hexane extract presented the recovering phenotype associated with reduced parasite levels. CONCLUSIONS: Extracts of A. mucosa are promising sources of novel antileishmanial compounds.

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