RESUMO
The aim of this study was to explore the therapeutic effect of Pleurotus eryngii cellulose on experimental fatty liver in rats. Rats were fed high-fat fodder to establish a rat fatty liver model, and were then fed different concentrations of Pleurotus eryngii cellulose for six weeks. Lipitor was used as a positive control. Measured levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), and total triglyceride (TG); the activity of malondialdehyde (MDA), superoxide dismutase (SOD), hepatic lipase (HL), and lipoprotein lipase; and liver histopathological changes. Successfully established rat fatty liver model after feeding high-fat fodder for one week. A diet of P. eryngii cellulose for six weeks significantly reduced ALT, AST, TC, and TG levels in rat serum (P < 0.01); TC and AST levels in P. eryngii cellulose high-dose group and Lipitor group were not significantly different from those of the control (P > 0.05). SOD activity increased significantly, while MDA and HL activity decreased (P < 0.05); fatty degeneration and fat accumulation both decreased in hepatic tissue. Hepatic protection of P. eryngii cellulose showed dose-related effect. P. eryngii cellulose can affect lipid metabolism, having therapeutic effects on fatty liver in rats.
Assuntos
Celulose/farmacologia , Fígado Gorduroso/tratamento farmacológico , Metabolismo dos Lipídeos/efeitos dos fármacos , Pleurotus , Alanina Transaminase/sangue , Animais , Aspartato Aminotransferases/sangue , Celulose/uso terapêutico , Colesterol/sangue , Modelos Animais de Doenças , Fígado Gorduroso/sangue , Fígado/efeitos dos fármacos , Masculino , Ratos , Triglicerídeos/sangueRESUMO
The EtOAc extract of the whole plant of the Argentinian species Nierembergia aristata showed significant cytotoxicity against eleven different cancer cell lines. In addition to several known compounds, bioassay-guided fractionation led to the isolation of three new cardenolides, 17-epi-11 alpha-hydroxy-6, 7-dehydrostrophanthidin-3-O-beta-boivinopyranoside[1],6, 7-dehydrostrophanthidin-3-O-beta-boivinopyranoside [2], and 6,7-dehydrostrophanthidin-3-O-beta-oleandropyranoside[3], of which the latter demonstrated activity against all the cell lines tested. To our knowledge, this is the first report of the isolation of cardiac glycosides from a species in the Solanaceae.