RESUMO

Parenteral omega-3 fatty acid lipid emulsions have been evaluated for their potential role in reversing intestinal failure-associated liver disease. We report our experience using Omegaven in 2 patients with irreversible intestinal failure and intestinal failure-associated liver disease. Despite biochemical and histologic improvement in cholestasis, both patients had persisting, significant portal fibrosis on liver biopsy.

Assuntos

Emulsões Gordurosas Intravenosas/uso terapêutico , Ácidos Graxos Ômega-3/uso terapêutico , Doença de Hirschsprung/terapia , Enteropatias/terapia , Cirrose Hepática Biliar/terapia , Nutrição Parenteral/métodos , Feminino , Humanos , Recém-Nascido , Cirrose Hepática Biliar/patologia , Masculino , Nutrição Parenteral/efeitos adversos , Falha de Tratamento