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The COVID-19 pandemic has had a significant impact on the health and economy of the global population. Even after recovery from the disease, post-COVID-19 symptoms, such as pulmonary fibrosis, continue to be a concern. This narrative review aims to address pulmonary fibrosis (PF) from various perspectives, including the fibrotic mechanisms involved in idiopathic and COVID-19-induced pulmonary fibrosis. On the other hand, we also discuss the current therapeutic drugs in use, as well as those undergoing clinical or preclinical evaluation. Additionally, this article will address various biomarkers with usefulness for PF prediction, diagnosis, treatment, prognosis, and severity assessment in order to provide better treatment strategies for patients with this disease.

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INTRODUCTION: Coronavirus disease 19 (COVID-19) has been a global public health emergency, with 209.89 million cases of infection with SARS-CoV-2 recorded, resulting in 4,401,675 deaths. After recuperation, it is probable that COVID-19 patients have sequelae of the disease. This study aimed to evaluate the respiratory anatomical-functional sequelae in Mexican patients who recovered from COVID-19. METHODOLOGY: This study included twenty-four patients who recovered from COVID-19 and eight non-infected patients (controls). Participants were screened for SARS-CoV-2 and the presence of IgM/IgG antibodies. Pulmonary function and lung anatomical abnormalities were evaluated by spirometry and computerized tomography. RESULTS: A total of 45.8% of the patients had pulmonary function with obstructive patterns: 70.8% of recovered cases had COVID-19 Reporting and Data System (CO-RADS) 1, 20.8% CO-RADS 3 and 16.7% CO-RADS 4. A total of 35.3% of patients with CO-RADS 1 also showed bilateral nodal growth; 70.8% of patients tested positive for IgG and 8.4% for IgG/IgM, and 20.8% tested negative for both antibodies. CONCLUSIONS: There were respiratory anatomical and functional sequelae in Mexican patients who recovered from COVID-19, with a high occurrence of pulmonary obstructive patterns in the study population. These observations indicate the importance of the routine evaluation of sequelae in Mexican patients who recovered from COVID-19 and the need for strict follow-up to improve the quality of life of these patients.

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Resumen La presente investigación tiene como objetivo identificar las diferencias en el desarrollo infantil en los niños con y sin antecedentes de consumo materno de sustancias en etapa gestacional, a través de la aplicación de la Escala Abreviada de Desarrollo Infantil "Nelson Ortiz", en una muestra de niños de entre 0 y 3 años de edad en situación de acogimiento institucional. Se realizó un estudio descriptivo y comparativo de grupos, en 36 participantes, de los cuales 18 tuvieron antecedentes de consumo materno y 18 sin antecedentes de consumo materno en etapa gestacional. Los niños estaban incorporados en Instituciones Públicas y las sustancias consumidas por los progenitores fueron: alcohol, cocaína, cannabinoides, cafeína y disolventes volátiles. Los resultados obtenidos a través del análisis de varianza con un factor ANOVA revelan que, existe diferencias significativas entre los valores (F=4,405; p< 0,01), lo cual permite determinar que, el consumidor que influye en mayor magnitud en el desarrollo global del niño es la madre consumidora y la sustancia más perjudicial es el alcohol. El análisis comparativo obtenidos a través de la prueba no paramétrica "U" de Mann-Whitney indica que, existen diferencias significativas de p<0,01 en el desarrollo global entre el grupo de consumo y no consumo de sustancias y; en las áreas de desarrollo son evidentes las diferencias significativas de p< 0,01 en el área motriz fino adaptativa y de p<0,05 en el área de audición y lenguaje.

Abstract This research aims to identify differences in child development in children with and without history of maternal consumption of substances in gestational stage, through the application of the Abbreviated Child Development Scale "Nelson Ortiz", in a sample of Children between 0 and 3 years of age in a situation of institutional care. A descriptive and comparative study of groups was carried out in 36 participants, of which 18 had a history of maternal consumption and 18 hadn't history of maternal consumption in the gestational stage. The children were incorporated into Public Institutions and the substances consumed by their parents were: alcohol, cocaine, cannabinoids, and caffeine and volatile solvents. The results obtained through the analysis of variance with an ANOVA factor reveal that, there are significant differences between the values (F= 4.405; p<0.01) which allows to determine that, the consumer that influences in greater magnitude in the global development is The child's mother and the most harmful substance is alcohol. The comparative analysis obtained through the non-parametric Mann-Whitney "U" test indicates that there are significant differences of p<0.01 in the overall development between the group of consumption and non-consumption of substances and; in the areas of development the significant differences of p<0.01 in the fine adaptive motor area and of p <0.05 in the area of hearing and language are evident.

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Resumen El diseño del Cuestionario de habilidades de adaptación conductual para adolescentes de 14 a 18 años de edad se desarrolló con el propósito de explorar conductas que promueven el ajuste psicológico frente a determinadas situaciones y conflictos a los que ellos se enfrentan. La construcción del instrumento de medición se basó en la planeación, la aplicación y el análisis de reactivos. Participaron 416 estudiantes pertenecientes a instituciones educativas fiscales, particulares y fiscomisionales, tanto urbanas como rurales. Inicialmente, el cuestionario estuvo conformado por 142 ítems, agrupados en tres categorías. Luego del análisis de fiabilidad de la prueba piloto, que determinó que la consistencia interna de la categoría cognitiva era baja, se conformaron dos categorías: la social-contextual y la práctico-funcional, en cuyos casos se observó una consistencia aceptable. En general, los ítems presentaron un coeficiente alto (α = .875). Así, para el análisis factorial se aplicó la prueba KMO (Kaiser-Meyer-Oblim) que arrojó una relación mediana en ambas categorías. La prueba de esfericidad de Bartlett (p < .001) posibilitó el análisis factorial y el gráfico de sedimentación que confirma la conformación del número de factores en la construcción del instrumento.

Abstract The design of the Behavioral Adaptation Abilities Questionnaire for adolescents between 14 and 18 years of age was developed in order to explore behaviors that promote psychological adjustments to certain situations and conflicts that they face. The design of the measurement tool was based on the planning, applying and analyzing of instruments. The participants were 416 students from public, private and fiscomisional educational institutions located in urban and rural areas. Initially, the questionnaire included 142 items, divided into three areas. After the reliability analysis obtained from the pilot test, that determined that the inner consistency of the cognitive area was low, two new areas were created: a social-contextual one and a practical-functional one, which showed an acceptable inner consistency. In general, the items showed a high coefficient (α = .875). Therefore, the KMO (Kaiser-Meyer-Oblim) test was applied in order to carry out a factorial analysis. The result was a median relation in both cases. Bartlett's sphericity test (p < .001) made the factorial analysis possible as well as the sedimentation graph that confirms the number of factors involved in the construction of the instrument.

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INTRODUCCIÓN El suicidio es un problema multicausal que tiene un gran impacto social, económico, familiar y psicológico a nivel mundial. Según la OMS, el suicidio es la segunda causa de muerte en jóvenes de 15 a 29 años. Desde la Dirección de Estadísticas e Información de Salud de Argentina se informó que de 2007 a 2014 el mayor número de suicidios se registran en ambos sexos entre los 15 y 24 años. A nivel local, en Bahía Blanca el número de intentos de suicidio en el rango etario de 11 a 19 años ha ido en aumento en los últimos tres años. OBJETIVO Describir las características de la red vincular de la población adolescente de 13 a 18 años que ingresa por Conducta Suicida a los Servicios Municipales de Urgencia (SMU) de Bahía Blanca. MÉTODOS Se realizó un estudio observacional, exploratorio de corte transversal, de índole cuali-cuantitativo. En virtud de nuestro objetivo se puso particular atención a la dimensión relacional del evento y a la descripción que el adolescente realiza de sus vínculos sociales. Nuestra muestra se conformó de 30 adolescentes, habiendo prestado consentimiento para llevar a cabo una entrevista semiestructurada 14 adolescentes; 13 mujeres y 1 varón. El análisis cuantitativo del estudio se basa en la interpretación de las variables volcadas en una base de datos a través del programa SPSS versión 21. Con relación al aspecto cualitativo, se utilizó el Método de Análisis Fenomenológico Interpretativo. RESULTADOS Registramos que el 73% de la muestra son mujeres, pero que los hombres eligen los métodos más letales. Los conflictos con el mundo adulto aparecen como factores concurrentes del acto, mientras que el conflicto con pares lo precipitan. DISCUSIÓN La percepción que el adolescente tiene sobre su red vincular impacta en la decisión de la conducta suicida. A su vez, podemos conjeturar que el acto suicida entrama una dimensión relacional dirigida al otro de la red social

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Los pacientes con cáncer son población de riesgo para adquirir infección por virus de hepatitis B por estar expuestos a métodos que favorecen la inoculación parenteral del virus. Cuantificar los anticuerpos contra el antígeno de superficie para el virus de hepatitis B en pacientes sin títulos protectores al momento de su ingreso en el servicio de hematooncología pediátrica que recibieron un esquema corto de vacunación (0, 1 y 2 meses). Entre marzo de 2008 y 2009, se recibieron 40 pacientes, excluyéndose 17 posteriormente del estudio, 8 por presentar marcadores positivos de infección para hepatitis B y 9 con títulos mayores de 100UI/L. Dieciséis pacientes sin títulos protectores recibieron vacuna recombinante. Se determinaron serologías para hepatitis B: Antígeno de superficie, Anticuerpo contra el antígeno de superficie y anticore, cada 3 meses, por 1 año, considerándose como títulos protectores anticuerpo contra el antígeno de superficie mayor de 100UI/L De los 16 (100%) pacientes que recibieron vacunación, 15 (94%) alcanzaron títulos protectores, los cuales presentaron descenso del anticuerpo contra el antígeno de superficie durante el tiempo de estudio. Los pacientes vacunados alcanzaron seroprotección con posterior disminución progresiva de sus títulos protectores lo que justifica su revacunación...

Patients with cancer are a population in risk of being infected by Hepatitis B virus as a consequence of being exposed to methods favoring the parenteral inoculation of the virus. Quantifying the antibodies against the surface antigen for Hepatitis B virus in patients without protection titers when admitted to the pediatric hematology-oncology service and who received a short vaccination schedule (0, 1, and 2 months). Between March 2008 and 2009, 40 patients were received, from which later on 17 were excluded from the study since 8 showed infection positive markers for Hepatitis B, and 9 with values higher than 100IU/L. 16 patients without protection titers were recombinant- vaccinated. Serologies for Hepatitis B were determined: Surface Antigen, Antibody against surface antigen, and anticore every 3 months during 1 year, being considered as the antibody protectors against the surface antigen higher than 100IU/L. Out of the 16 patients (100%) who were vaccinated: 15 (94%) reached protection titers, showing antibody decrease against surface antigen in the study term. Vaccinated patients reached seroprotection with later progressive diminishing of protection titers, thus justifying revaccination...

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Central sensitization theory has been defined as pivotal for understanding the excitability changes in central neurons following peripheral inflammation or neuropathic injury. Considerable evidence has demonstrated that activation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors and subsequent nitric oxide (NO) production are the key in these changes. Consequently, neuromodulator drugs have been developed during the last decades. The electroacupuncture (EA) that acts as biochemical modulator in the spinal horn cord would prevent these changes. The aim of this study was to determine the thermal anti-hyperalgesic effect of EA (10 Hz, 3 mA) and its combination with L-NAME as nitric oxide synthase (NOS) inhibitor in carrageenan-induced hyperalgesia in rats. Also, it investigated the changes in the plasmatic concentrations of NO metabolites. Moreover, the EA combination with sub-effective dose of ketamine as a NMDA antagonist was tested. The EA pre-treatment conducted in unsedated, unrestrained and conscious animals showed a thermal anti-hyperalgesic effect in correspondence with plasmatic increase of NO metabolites. The L-NAME (30 mg/kg) pre-administration decreased significantly the plasmatic concentrations of NO(2)(-)/NO(3)(-) and suppressed the anti-hyperalgesic effect of EA. The combination of EA with ketamine enhanced the anti-hyperalgesic effect. These data constitute the first report that suggested the participation, at least in part, of the L-arginine-NOS-NO-GMPc pathway activation in anti-hyperalgesic effect of EA in carrageenan-induced inflammation model.

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ETHNOPHARMACOLOGICAL RELEVANCE: Heliopsis longipes (A. Gray) Blake (Asteraceae) is a broadly used species in the Mexican, Central and South American Traditional Medicine for its anaesthetic, analgesic, anti-inflammatory and anti-ulcerative properties. The ethanolic extract contains alkamides, mainly affinin (spilanthol). This family of compounds exerts an in vitro inhibitory action on the cyclooxygenase and lipoxygenase enzymes. AIM OF THE STUDY: The present study approaches the anti-inflammatory effect of the extract and its main bioactive component affinin and derived isobutyl-decanamide. MATERIALS AND METHODS: The anti-inflammatory effect was evaluated through the mouse ear oedema test by means of two irritating agents, arachidonic acid (AA) and phorbol myristate acetate (PMA). RESULTS: Heliopsis longipes, affinin and isobutyl-decanamide displayed a marked anti-inflammatory effect on the AA model with ED(50)=0.8, 1.2 and 0.9 mg/ear, respectively. Nimesulide (1 mg/ear) was used as a reference drug. In PMA model, the extract and two alkamides also showed a dose-dependent anti-inflammatory effect with ED(50)=2.0, 1.3 and 1.1 mg/ear, respectively. Indomethacin (3 mg/ear) was used as reference drug. CONCLUSIONS: These results could represent an important contribution to explain the anti-inflammatory ethnobotanical effects reported for Heliopsis longipes and other species containing affinin (spilanthol). For the first time the topical anti-inflammatory effects of Heliopsis longipes, affinin and isobutyl-decanamide were studied.

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