RESUMO
The objective was to evaluate the relationship between follicular fluid levels of Interleukin-6 (IL-6) and the seric concentrations of estradiol and progesterone during controlled ovarian hyper-stimulation. The levels of IL-6 were measured in follicular fluid of 15 patients undergone to in vitro fertilization and embryo transfer and correlated with the values of seric estradiol and progesterone. There were a negative correlation between follicular levels of IL-6 and either estradiol and progesterone. Four patients achieved pregnancy following embryo transfer (pregnancy rate 26.6%), one of them aborted. As conclusion, the increased levels of IL-6 may be a reaction to controlled ovarian hyper-stimulation and probably a protective response. According to the reduction of estradiol, there may be a subtle reduction in aromatase action by effect of IL-6 and other cytokines.
Assuntos
Transferência Embrionária , Estradiol/sangue , Fertilização in vitro , Líquido Folicular/química , Interleucina-6/análise , Progesterona/sangue , Adulto , Feminino , Humanos , Imunoensaio , Indução da Ovulação , Fotometria , GravidezRESUMO
The objective was to evaluate the effect of the endoscopic treatment of the polycystic ovary syndrome (PCOS) in a murine model induced with depot estrogen. Three groups with PCOS were studied: group 1 (n = 22) evaluated exclusively using laparoscopy; group 2 (n = 11) one fulguration on both ovaries was performed during laparoscopy; and group 3 (n = 10) three fulgurations were performed. One month after laparoscopy the animal were sacrificed and was carried surgical microscopic examination of the intraabdominal organs, moreover histological evaluation of the gonads was practiced. All the animals showed PCOS. No adhesions were observed in the animals of group 1, while the frequency of adhesion in group 2 was 36.3%, 18.1% of the animals of group 2 showed gonadal atrophy. The frequency of adhesions in the group 3 was 66.6%. The adhesion score was significantly higher in groups 2 and 3 than in group 1. Is concluded that the use of estrogen is useful to induce PCOS in animal models. The procedure can be employed to study the effects of the surgical induction of ovulation, it's utility in other conditions seems promissary.
Assuntos
Indução da Ovulação , Síndrome do Ovário Policístico , Animais , Modelos Animais de Doenças , Feminino , Laparoscopia , Camundongos , Indução da Ovulação/instrumentação , Indução da Ovulação/métodosRESUMO
The objective was to evaluate the molecular ratio between the serum levels of progesterone (P) and estradiol (E2) and to determine it's effect on the in vitro fertilization performance. Sixty two couples were studied, the molecular P:E2 ratio was established the day of human chorionic gonadotropin (hCG) injection. The mean serum P concentration the day of hCG administration 1.45 +/- 0.50 ng/mL, while the mean P:E2 ratio was 0.63 +/- 0. Pregnancies were observed since molecular ration of 0.22, no pregnancies were obtained if the molecular ratio was > 1.02. No significant difference was detected in the fertilization and pregnancy rates in the patients who have or not premature luteinization. The implantation rate was low in patients with premature luteinization, however, there was not significant difference with patients without premature luteinization. In conclusion, the P:E2 ratio surrounding 1.0 is desirable to obtain adequate results in in vitro fertilization programs. In this work as others, the premature luteinization do not have effect in the reproductive results.
Assuntos
Gonadotropina Coriônica Humana Subunidade beta/administração & dosagem , Estradiol/sangue , Fertilização in vitro , Infertilidade , Hormônio Luteinizante/metabolismo , Progesterona/sangue , Feminino , Humanos , Síndrome de Hiperestimulação Ovariana/etiologia , GravidezRESUMO
Schmidt's syndrome is characterized by the existence of adrenal insufficiency and lymphocytic thyroiditis, yet, it can also be accompanied of some other autoimmune diseases. Addison's disease usually produces infertility due to chronic anovulation, but patient who are properly treated can still be fertile. There are few reports of pregnancy and Schmidt's syndrome, this work presents a case treated with hormonal substitution therapy and successful obstetric outcome.
Assuntos
Anti-Inflamatórios/uso terapêutico , Hidrocortisona/uso terapêutico , Poliendocrinopatias Autoimunes , Complicações na Gravidez , Adulto , Anti-Inflamatórios/administração & dosagem , Feminino , Humanos , Hidrocortisona/administração & dosagem , Recém-Nascido , Injeções Intravenosas , Poliendocrinopatias Autoimunes/diagnóstico , Poliendocrinopatias Autoimunes/tratamento farmacológico , Gravidez , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/tratamento farmacológicoRESUMO
Ovarian pregnancy is an uncommon presentation of ectopic pregnancy. It's frequency is 0.3-3.0 of all ectopic gestations. Is reported the case of a 33-year old female patient without previous pathology, was admitted because of lower abdominal pain, bloody vaginal discharge, a right adnexal mass, and positive serum pregnancy test. The preoperative diagnosis was tubal ectopic pregnancy. The following case report illustrates the successful application of operative laparoscopy for to treat primary ovarian pregnancy.