RESUMO
Triple-negative tumors are characterized immunohistochemically by the absence of positivity to sex hormone receptors and to human epidermal growth factor receptor 2. Additionally, they are differentiated into basal-like and non-basal (or null) subtypes, based on the presence of basal cytokeratin expression (CK5/6, 14, and17). Triple-negative subtypes are yet to be characterized in male dogs, to our knowledge. We report herein the clinical and pathologic findings and molecular characterization of carcinoma in the mammary glands of 2 male dogs. Case 1 was diagnosed as a grade II tubulopapillary carcinoma; case 2 was diagnosed as a grade II carcinoma in a mixed tumor. The tumors were characterized phenotypically as triple-negative basal and triple-negative non-basal, respectively.
Assuntos
Carcinoma/veterinária , Neoplasias Mamárias Animais/genética , Receptores de Estrogênio/genética , Animais , Biomarcadores Tumorais/metabolismo , Carcinoma/genética , Carcinoma/patologia , Cães , Regulação Neoplásica da Expressão Gênica , Imuno-Histoquímica , Masculino , Neoplasias Mamárias Animais/patologia , Receptores de Progesterona/metabolismoRESUMO
Mammary neoplasms are the most frequent tumors in female dogs. Of these neoplasms, benign mixed tumors (BMTs) and carcinomas in mixed tumors (CMTs) represent a large proportion of small animal oncology diagnoses. Together with carcinosarcomas (CSs), these three neoplastic entities are characterized by the proliferation of benign or malignant epithelial, myoepithelial, and mesenchymal cells, depending on their histological types. This histological heterogeneity, in addition to their molecular heterogeneity, confers these tumors with distinct biological behavior, which results in the need for different clinical and therapeutic approaches. The present consensual document elucidates the oncological issues related to the diagnosis, prognosis, and treatment of BMTs, CMTs, and CSs of the canine mammary gland.(AU)
Assuntos
Animais , Feminino , Cães , Carcinossarcoma/veterinária , Carcinoma/diagnóstico , Carcinoma/veterinária , Carcinossarcoma/diagnóstico , /diagnóstico , Neoplasias Mamárias Animais/tratamento farmacológicoRESUMO
Mammary neoplasms are the most frequent tumors in female dogs. Of these neoplasms, benign mixed tumors (BMTs) and carcinomas in mixed tumors (CMTs) represent a large proportion of small animal oncology diagnoses. Together with carcinosarcomas (CSs), these three neoplastic entities are characterized by the proliferation of benign or malignant epithelial, myoepithelial, and mesenchymal cells, depending on their histological types. This histological heterogeneity, in addition to their molecular heterogeneity, confers these tumors with distinct biological behavior, which results in the need for different clinical and therapeutic approaches. The present consensual document elucidates the oncological issues related to the diagnosis, prognosis, and treatment of BMTs, CMTs, and CSs of the canine mammary gland.
Assuntos
Feminino , Animais , Cães , Carcinoma/diagnóstico , Carcinoma/veterinária , Carcinossarcoma/diagnóstico , Carcinossarcoma/veterinária , Neoplasias Mamárias Animais/tratamento farmacológicoRESUMO
The aim of this study was to characterize the pathological and epidemiological data related to the clinical evaluation of canine patients with mammary lesions presented at the Veterinary Hospital of Federal University of Bahia, Salvador Bahia, Brazil.[...]
Assuntos
Feminino , Animais , Cães , Glândulas Mamárias Animais/lesões , Neoplasias Mamárias Animais/epidemiologia , Neoplasias Mamárias Animais/patologiaRESUMO
The aim of this study was to characterize the pathological and epidemiological data related to the clinical evaluation of canine patients with mammary lesions presented at the Veterinary Hospital of Federal University of Bahia, Salvador Bahia, Brazil.[...](AU)