RESUMO
The novel antifungal compound majusculoic acid was isolated from a cyanobacterial mat microbial community. The structure of majusculoic acid was solved by interpretation of mass spectrometric and NMR data and conversion to the corresponding methyl ester. Majusculoic acid exhibits antifungal activity against Candida albicans ATCC 14503 (MIC 8 microM).
Assuntos
Antifúngicos/isolamento & purificação , Candida albicans/efeitos dos fármacos , Cianobactérias/química , Ácidos Graxos Insaturados/isolamento & purificação , Hidrocarbonetos Bromados/isolamento & purificação , Antifúngicos/química , Antifúngicos/farmacologia , Bahamas , Ácidos Graxos Insaturados/química , Ácidos Graxos Insaturados/farmacologia , Hidrocarbonetos Bromados/química , Hidrocarbonetos Bromados/farmacologia , Testes de Sensibilidade Microbiana , Estrutura Molecular , Ressonância Magnética Nuclear BiomolecularRESUMO
A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 mug/mL and against Candida glabrata with a MIC of 30 microg/mL.
Assuntos
Antifúngicos/isolamento & purificação , Candida/efeitos dos fármacos , Dodecanol/análogos & derivados , Dodecanol/isolamento & purificação , Urocordados/química , Animais , Antifúngicos/química , Antifúngicos/farmacologia , Brasil , Dicroísmo Circular , Dodecanol/química , Dodecanol/farmacologia , Estrutura Molecular , EstereoisomerismoRESUMO
[structure: see text]. A new 36-membered macrolactone, (25S,27S,29S,33S)-caylobolide A, was isolated from the Bahamian cyanobacterium Lyngbya majuscula. The structure of caylobolide contains an unprecedented repeated unit-a contiguous pentad of 1,5 diols-and a 1,3,5-triol. The relative steroechemistry of the 1,3,5-triol was determined using Kishi's Universal NMR database, and absolute stereochemistry at C25,27,29 and C33 were determined by Mosher's analysis. Caylobolide A exhibited in vitro cytotoxicity against human colon tumor cells (IC50 HCT 116, 9.9 microM).