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1.
Eur J Pain ; 15(2): 132-8, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20619707

RESUMO

Injury to the insular cortex in humans produces a lack of appropriate response to pain. Also, there is controversial evidence on the lateralization of pain modulation. The aim of this study was to test the effect of insular cortex lesions in three models of pain in the rat. An ipsilateral, contralateral or bilateral radiofrequency lesion of the rostral agranular insular cortex (RAIC) was performed 48h prior to acute, inflammatory or neuropathic pain models in all the experimental groups. Acute pain was tested with paw withdrawal latency (PWL) after thermal stimulation. Inflammation was induced with carrageenan injected in the paw and PWL was tested 1h and 24h afterwards. Neuropathic pain was tested after ligature of the sciatic nerve by measuring mechanical nociceptive response after stimulation with the von Frey filaments. Another model of neuropathy consisted of thermo stimulation followed by right sciatic neurectomy prior to the recording of autotomy behaviour. Acute pain was not modified by the RAIC lesion. All the RAIC lesion groups showed diminished pain-related behaviours in inflammatory (increased PWL) and neuropathic models (diminished mechanical nociceptive response and autotomy score). The lesion of the RAIC produces a significant decrease in pain-related behaviours, regardless of the side of the lesion. This is a clear evidence that the RAIC plays an important role in the modulation of both inflammatory and neuropathic - but not acute - pain.


Assuntos
Comportamento Animal/fisiologia , Córtex Cerebral/fisiopatologia , Hiperalgesia/fisiopatologia , Inflamação/fisiopatologia , Neuralgia/fisiopatologia , Análise de Variância , Animais , Hiperalgesia/psicologia , Inflamação/psicologia , Masculino , Neuralgia/psicologia , Medição da Dor , Estimulação Física , Ratos , Ratos Wistar
2.
Eur J Pain ; 11(4): 444-51, 2007 May.
Artigo em Inglês | MEDLINE | ID: mdl-16887371

RESUMO

Taurine is an inhibitory amino-acid which has been proposed as a nociceptive process neuromodulator. The glycine(A) receptor (glyR(A)) has been postulated as a receptor in which taurine exerts its function. Functional image studies have documented the role of the anterior cingulate cortex (ACC) in the affective component of pain. The aim of this study was to investigate the role of taurine as a glycinergic agonist in the ACC using a neuropathic pain model related to autotomy behaviour (AB). In order to test whether glyR(A) is responsible for taurine actions, we microinjected strychnine, a glyR(A) antagonist. We used taurine microinjected into the ACC, followed by a thermonociceptive stimulus and a sciatic denervation. Chronic nociception was measured by the autotomy score, onset and incidence. The administration of taurine 7 days after denervation modifies the temporal course of AB by inhibiting it. Our results showed a decreased autotomy score and incidence in the taurine groups, as well as a delay in the onset. Those experimental groups in which strychnine was microinjected into the ACC, either on its own or before the microinjection of taurine, showed no difference as compared to the control group. When taurine was microinjected prior to strychnine, the group behaved as if only taurine had been administered. Our results evidence a significant neuropathic nociception relief measured as an AB decrease by the microinjection of taurine into the ACC. Besides, the role of the glyR(A) is evidenced by the fact that strychnine antagonises the antinociceptive effect of taurine.


Assuntos
Giro do Cíngulo/fisiologia , Dor/tratamento farmacológico , Dor/etiologia , Doenças do Sistema Nervoso Periférico/complicações , Receptores de Glicina/efeitos dos fármacos , Taurina/uso terapêutico , Animais , Comportamento Animal/fisiologia , Glicinérgicos/administração & dosagem , Glicinérgicos/farmacologia , Masculino , Microinjeções , Dor/psicologia , Medição da Dor/efeitos dos fármacos , Ratos , Ratos Wistar , Receptores de Glicina/antagonistas & inibidores , Estricnina/administração & dosagem , Estricnina/farmacologia , Taurina/administração & dosagem
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