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Introducción. Uno de los principales desafíos para la primera infancia es brindar cuidados adecuados que reduzcan desigualdades y promuevan desarrollo infantil temprano (DIT). El objetivo del trabajo fue describir relaciones entre los cuidados que reciben niños y niñas de 3 y 4 años, según el marco para el cuidado cariñoso y sensible (NC, por sus siglas en inglés), y sus niveles de DIT en Argentina, considerando región y quintiles de riqueza. Población y métodos. Estudio analítico observacional de corte transversal, a partir de las bases de datos de la Encuesta Nacional de Niñas, Niños y Adolescentes (MICS) Argentina 2019-2020. Se seleccionaron 11 indicadores de NC y se estimó el nivel de DIT utilizando el Índice de Desarrollo Infantil Temprano (ECDI) para un análisis estadístico descriptivo. Resultados. En 2638 niños y niñas de 3 y 4 años evaluados, el promedio de acceso a indicadores de cuidados fue del 79,1 %; el acceso fue alto en 7 indicadores (entre el 84,2 % y el 97,9 %) y medio en 4 (entre el 46,9 % y el 65,1 %); la mayor frecuencia fue contar con registro de nacimiento (97,9 %) y la menor, la cobertura de seguro de salud (46,9 %). El 87,9 % alcanzó niveles adecuados de ECDI. Los resultados registran diferencias según quintiles de riqueza y regiones. Conclusiones. Los resultados evidencian desigualdades de acceso a cuidados y en DIT adecuado de niños y niñas de 3 y 4 años de áreas urbanas de Argentina según la región donde viven y el nivel de riqueza de sus hogares.

Introduction. One of the main challenges for early childhood is to provide adequate care to reduce inequalities and promote an early childhood development (ECD). The objective of this study was to describe the relationship between the care provided to children aged 3 and 4 years according to the nurturing care (NC) framework and their ECD levels in Argentina, considering the region and wealth quintiles. Population and methods. This was an observational, cross-sectional analytical study based on data from the National Survey of Children and Adolescents (MICS) of Argentina 2019­2020. A total of 11 NC indicators were selected; the level of ECD was estimated using the Early Childhood Development Index (ECDI) for a descriptive, statistical analysis. Results. In 2638 children aged 3 and 4 years assessed, the average access to care indicators was 79.1%; access was high for 7 indicators (between 84.2% and 97.9%) and middle for 4 indicators (between 46.9% and 65.1%); the highest and lowest frequency corresponded to having a birth certificate (97.9%) and health insurance coverage (46.9%), respectively. Adequate ECDI levels were observed in 87.9%. Results show differences by wealth quintile and region. Conclusions. The results evidence inequalities in terms of access to care and an adequate ECD of children aged 3 and 4 years from urban areas of Argentina, depending on the region where they live and their household wealth level.

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Introduction. Dietary quality involves both the quantity and quality of food offered, the way and the setting in which it is offered, and the responses of the person offering it. The objective of this study was to identify behavioral patterns related to responsive feeding in children aged 6 to 23 months in urban areas from Argentina in 2018-2019. Population and methods. Secondary analysis based on data from the second National Survey on Nutrition and Health of 2018-2019 conducted in a multistage probability sample from urban areas of 5000 inhabitants or more in Argentina. A descriptive analysis and a principal component analysis were performed to identify responsive feeding patterns in 4379 children aged 6 to 23 months. Results. Five responsive feeding patterns were identified; the first 2 dimensions explained 71.1% of inertia (p = 0.013). The pattern with a prevailing possibility of experimentation, autonomy, interaction, and the absence of screens, rewards and distractions was associated with children older than 12 months from the central and south regions (Cuyo, Pampa, Greater Buenos Aires, and Patagonia), whereas the pattern related to a lower autonomy, experimentation, and self-regulation corresponded to children aged 6 to 11 months from the Northwest and Northeast regions. Conclusion. There is evidence of responsive feeding practices that correspond to distinguishable patterns, associated with different stages of life and with the region where the children live.

Introducción. La calidad de la alimentación implica tanto la cantidad y calidad de los alimentos que se ofrecen como la forma en que se ofrecen, el entorno y las respuestas de quien los ofrece. El objetivo de este trabajo fue identificar patrones de comportamiento relacionados a la alimentación perceptiva en niños entre 6 y 23 meses de áreas urbanas de la Argentina en 2018-19. Población y métodos. Análisis secundario de datos de la 2.a Encuesta Nacional de Nutrición y Salud 2018-19, de una muestra probabilística polietápica de localidades urbanas de 5000 habitantes y más de Argentina. Se realizó análisis descriptivo y análisis de componentes principales para identificar los patrones de alimentación perceptiva en 4379 niños y niñas de 6 a 23 meses. Resultados. Se identificaron cinco patrones de alimentación perceptiva, las dos primeras dimensiones explicaron el 71,1 % de la inercia (p = 0,013). El patrón donde prevalecía la posibilidad de experimentación, la autonomía, la interacción y la ausencia de pantallas, premios y distracciones se asoció a niños/as mayores de 12 meses, de las regiones del centro y sur (Cuyo, Pampeana, Gran Buenos Aires y Patagonia), mientras que el patrón relacionado con menor autonomía, experimentación y autorregulación correspondió a las regiones Noroeste y Noreste, y a niños/as entre 6 y 11 meses. Conclusión. Se evidencian prácticas de alimentación perceptiva que se corresponden con patrones diferenciados entre sí, asociados a diferentes etapas y a la región donde viven los niños/as.

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BACKGROUND: Irritable bowel syndrome (IBS) is a functional disorder commonly associated with extra-intestinal symptoms. However, the prevalence of these symptoms according to IBS subtype is not well established. AIM: To compare the prevalence of extra-intestinal symptoms among patients with different subtypes of IBS. METHODS: A descriptive cross-sectional study including patients with IBS according to Rome IV criteria was performed between July 2022 and April 2023. Patients were classified according their subtype of IBS: IBS-D (diarrhea-predominant), IBS-C (constipation-predominant), and IBS-M (mixed bowel habits). Patients completed the IBS severity scoring system questionnaire (IBS-SSS) to determine severity of IBS symptoms and patient health questionnaire- 9 (PHQ-9) to define presence and severity of depressive symptoms. The prevalence of reported extra-intestinal symptoms was also assessed and compared between groups. KEY RESULTS: A total of 4862 patients with IBS were included; 608 IBS-D (12.5%), 1978 IBS-C (40.7%), and 2276 IBS-M (46.8%). Patients with IBS-C had significantly lower IBS-symptoms severity (mean IBS-SSS 290 vs. 310 and 320 for IBS-D and IBS-M, respectively, p = 0.03). The prevalence of obesity was also significantly lower in these patients (17.1% vs. 30.9% IBS-D and 27.9% IBS-M, p = 0.0001). Patients with IBS-D showed a significantly higher prevalence of food intolerance perception (9.5%, p = 0.03), history of cholecystectomy (17.8%, p = 0.03), and fecal incontinence (36.2%, p = 0.0001) as compared to the other groups. Patients with IBS-M had significantly higher mean PHQ-9 score (12.7 vs. 11.1 IBS-D and 10.5 IBS-C, p = 0.001) and prevalence of depressive symptoms (80.0%, p = 0.01). Patients with IBS-M also had higher prevalence of extra-intestinal symptoms such as arthralgia (62.4%, p = 0.0001), extremity numbness (64.5%, p = 0.0001), atopic dermatitis (28.2%, p = 0.02), and chronic cervicalgia (81.0%, p = 0.01). CONCLUSIONS & INFERENCES: The prevalence of most extra-intestinal symptoms is higher among patients with IBS-M. Further research is needed to better characterize IBS subtypes, which could potentially help refining tailored therapeutic strategies.

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Introduction. One of the main challenges for early childhood is to provide adequate care to reduce inequalities and promote an early childhood development (ECD). The objective of this study was to describe the relationship between the care provided to children aged 3 and 4 years according to the nurturing care (NC) framework and their ECD levels in Argentina, considering the region and wealth quintiles. Population and methods. This was an observational, cross-sectional analytical study based on data from the National Survey of Children and Adolescents (MICS) of Argentina 2019-2020. A total of 11 NC indicators were selected; the level of ECD was estimated using the Early Childhood Development Index (ECDI) for a descriptive, statistical analysis. Results. In 2638 children aged 3 and 4 years assessed, the average access to care indicators was 79.1%; access was high for 7 indicators (between 84.2% and 97.9%) and middle for 4 indicators (between 46.9% and 65.1%); the highest and lowest frequency corresponded to having a birth certificate (97.9%) and health insurance coverage (46.9%), respectively. Adequate ECDI levels were observed in 87.9%. Results show differences by wealth quintile and region. Conclusions. The results evidence inequalities in terms of access to care and an adequate ECD of children aged 3 and 4 years from urban areas of Argentina, depending on the region where they live and their household wealth level.

Introducción. Uno de los principales desafíos para la primera infancia es brindar cuidados adecuados que reduzcan desigualdades y promuevan desarrollo infantil temprano (DIT). El objetivo del trabajo fue describir relaciones entre los cuidados que reciben niños y niñas de 3 y 4 años, según el marco para el cuidado cariñoso y sensible (NC, por sus siglas en inglés), y sus niveles de DIT en Argentina, considerando región y quintiles de riqueza. Población y métodos. Estudio analítico observacional de corte transversal, a partir de las bases de datos de la Encuesta Nacional de Niñas, Niños y Adolescentes (MICS) Argentina 2019-2020. Se seleccionaron 11 indicadores de NC y se estimó el nivel de DIT utilizando el Índice de Desarrollo Infantil Temprano (ECDI) para un análisis estadístico descriptivo. Resultados. En 2638 niños y niñas de 3 y 4 años evaluados, el promedio de acceso a indicadores de cuidados fue del 79,1 %; el acceso fue alto en 7 indicadores (entre el 84,2 % y el 97,9 %) y medio en 4 (entre el 46,9 % y el 65,1 %); la mayor frecuencia fue contar con registro de nacimiento (97,9 %) y la menor, la cobertura de seguro de salud (46,9 %). El 87,9 % alcanzó niveles adecuados de ECDI. Los resultados registran diferencias según quintiles de riqueza y regiones. Conclusiones. Los resultados evidencian desigualdades de acceso a cuidados y en DIT adecuado de niños y niñas de 3 y 4 años de áreas urbanas de Argentina según la región donde viven y el nivel de riqueza de sus hogares.

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BACKGROUND: The COVID-19 pandemic created a backlog in colorectal cancer (CRC) screening and surveillance colonoscopies. The real impact in Argentina is not fully known. GOAL: To estimate the impact of the COVID-19 pandemic on CRC prevention by comparing the number of CRC screening and surveillance consults in a clinical decision support-tool used in Argentina before, during and after pandemic lockdown. METHODS: We analyzed data from May 2019 to December 2021 from CaPtyVa, a clinical decision support tool for CRC screening and surveillance. Queries were divided in pre-pandemic (May 2019 to March 2020), lockdown (April 2020 to December 2020), and post-lockdown (January 2021 to December 2021). The number of CRC monthly screening and surveillance visits were compared among the three periods and stratified according to CRC risk. RESULTS: Overall, 27,563 consults were analyzed of which 9035 were screening and 18,528 were surveillance. Pre-pandemic, the median number of screening consults was 346 per month (IQR25-75 280-410). There was a decrease to 156 (80-210)/month (p<0.005) during lockdown that partially recovered during post-lockdown to 230 (170-290)/month (p=0.05). Pre-pandemic, the median number of surveillance consults was 716 (560-880)/month. They decreased to 354 (190-470)/month during lockdown (p<.05) and unlike screening, completely recovered during post-lockdown to 581 (450-790)/month. CONCLUSIONS: There was a >50% decrease in the number of CRC screening and surveillance consults registered in CaPtyVa during lockdown in Argentina. Post-lockdown, surveillance consults recovered to pre-pandemic levels, but screening consults remained at 66% of pre-pandemic levels. This has implications for delays in CRC diagnoses and patient outcomes.

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The state of Rio Grande do Norte, located in the Northeast region of Brazil, has areas of granites and pegmatites with minerals that have varying concentrations of uranium. Consequently, high concentrations of radon gas, a carcinogenic substance for humans, can occur. The present study aimed to assess the occurrence of cancer and its association with exposure to sources of natural radioactivity using geological and geophysical information in the aforementioned state. The spatial dependence of pulmonary, breast, stomach, leukemia, and skin cancer cases with the location of radioisotope sources were analyzed using geoprocessing tools. The geoprocessing analysis showed a differential pattern of uranium emission throughout the state, with the highest emission from areas with pegmatites outcrops. A spatial dependency of cancer cases was shown (Moran index: 0.43; p < 0.01). Moreover, a higher rate of natural radioactivity-cancer cases was associated with the high-intensity natural radioactivity areas: odds ratio:1.21 (95% CI 1.20; 1.23), following the same pattern when separately compared the different related types of cancer. These results highlight the importance of natural radioactivity as a public health problem in the Brazilian environmental scenario, confirming the need for further studies as the first toward understanding and implementing health management strategies mitigating the exposures, especially in areas of environmental risk.

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RESUMEN INTRODUCCIÓN En 2020, primer año de pandemia (AP) de COVID-19, Argentina focalizó las acciones en la nueva enfermedad y dejó relegado el monitoreo de las otras (noCOV). El objetivo de este trabajo fue comparar la mortalidad por causas noCOV durante el AP con respecto a los 5 años del período previo a la pandemia (PPP) MÉTODOS Se realizó un estudio transversal con fuentes de datos secundarias y base poblacional nacional. Se utilizó la causa básica de muerte, desagregada a nivel de capítulo y grupos según la Clasificación Internacional de Enfermedades, 10a revisión. Se estimaron las tasas brutas (TBM) y ajustadas (TAM) de mortalidad, comparando con test t y considerando como significativo un valor p<0,05. Se calculó el exceso de mortalidad (EM) realizando la diferencia entre el número de defunciones noCOV del AP y el intervalo de confianza del 95% superior o inferior de la media de casos del PPP RESULTADOS La TBM disminuyó 9,1%, y el EM fue de -4,5%. Salvo en el caso de la diabetes mellitus y las enfermedades respiratorias sin especificar, la TAM disminuyó significativamente durante el AP. La mayor variación de TBM fue por infecciones respiratorias agudas bajas en menores de 19 años y por accidentes de transporte en adultos de 20 a 59 años y de 60 años o más (reducción de 46,3% y 48,8%, respectivamente) DISCUSIÓN Durante el AP hubo una disminución de la mortalidad por noCOV especialmente en el caso de las infecciones respiratorias agudas y los accidentes de tránsito.

ABSTRACT INTRODUCTION During 2020, the first year of the pandemic (YP), Argentina focused the actions on the new disease, leaving aside the monitoring of diseases other than COVID-19 (non-COV). The objective of this work was to compare mortality from non-COV causes during the YP with respect to the 5 years of the pre-pandemic period (PPP) METHODS A cross-sectional study was conducted using secondary data sources and national population-based data. The basic cause of death was disaggregated at the chapter and group level according to the International Classification of Diseases, 10th revision. Crude (CMR) and adjusted mortality rates (AMR) were estimated, comparing with t-test and considering significant a p-value<0.05. Excess mortality (EM) was calculated as the difference between the number of non-COV deaths in the YP and the upper or lower 95% confidence interval (CI95%) of the mean number of PPP cases RESULTS The CMR decreased by 9.1% and EM was -4.5%. Except for diabetes mellitus and unspecified respiratory diseases, the AMR showed a significant reduction during the YP. The greatest variation of CMR was due to acute lower respiratory infections in people under 19 years of age and due to transport accidents in adults aged 20 to 59 years and adults aged 60 or older (reduction of 46.3% and 48.8%, respectively) DISCUSSION During the YP there was a decrease in mortality due to non-COV causes, especially those related to acute respiratory infections and transport accidents.

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Introduction: College students represent an important subpopulation of the United States, with over 19 million college students in the U.S. enrolled yearly. Methods: Descriptive analysis of the causes of death for all deceased students reported by the UW Dean of Students Office (DSO) between 2004 and 2018. We analyzed frequencies and yearly rates. Results: Our analysis shows that contrary to published data and national statistics for the relevant age groups, intentional by self-harm deaths lead causes of death in enrolled students from 2004 to 2018. Intentional by self-harm is the main cause of death in male students, younger students, and white students. "Other" causes of death is the main cause in female students, older students, and students of color. Conclusions: These results must be shared with different stakeholders across campus as well as with other universities in order to support and evaluate campus-wide prevention strategies for means restriction and environmental safety.

Introducción: Los estudiantes universitarios representan una subpoblación importante de los Estados Unidos, con más de 19 millones de matriculados anualmente. Sin embargo, hay pocos datos publicados sobre la mortalidad y causas de muerte en la población universitaria. El propósito de este estudio fue analizar las causas de muerte, basadas en datos de certificados de defunción, de estudiantes matriculados en University of Winconsin- Madison desde 2004 hasta 2018. Métodos: Análisis descriptivo de las causas oficiales de muerte de todos los estudiantes fallecidos reportados por la Oficina del Decano de Estudiantes entre 2004 y 2018. Se analizaron frecuencias y tasas anuales. Resultados: El análisis muestra que, contrariamente a los datos publicados y las estadísticas nacionales para los grupos de edad relevantes, las muertes intencionales por autolesión lideran las causas de muerte en los estudiantes matriculados entre esos años. Las autolesiones intencionales son la principal causa de muerte en los estudiantes varones, en los estudiantes más jóvenes y en los estudiantes blancos. Las causas incluidas en la categoría indicada como Otras son las principales en las estudiantes mujeres, en estudiantes mayores y en estudiantes de color. Conclusiones: Los resultados de este estudio deben compartirse con las diferentes áreas interesadas en todo el campus universitario y con otras instituciones universitarias, para apoyar y evaluar las estrategias de prevención, la aplicación de los medios de restricción y la seguridad ambiental.

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Introduction: COVID-19 pandemic has had a great impact on health systems. Many non-urgent visits were done virtually to limit exposure risks. Objective: Assess the impact of the pandemic on STI (sexually transmitted infections) testing in a college health setting. Material and methods: Quantitative assessment of the number of STI tests done, positive rates and percentage of "compliance to follow-up" for diagnosed STI from March to December 2020 and its comparison with historical data (2015-2019) at the University Health Services, UW-Madison. Measurement: Observed (2020) vs expected (2015-2019) number of STI tests, positive rates and compliance to follow-up testing for STIs. Results: The 2020 period showed a significant decrease in the number of tests done and an increase of positive rate when compared to historical data for total sample and per sex. There was a decrease in the percentage of follow-up for the entire sample and for females and an increase for males. Conclusions: In accordance with national data, our analysis shows significant declines in STI testing and follow-up during 2020 compared to previous years and an increase in positivity rate. A higher positivity with lower number of tests is likely due to triaging patients, facilitating testing for those at highest risk.

Introducción: La pandemia de COVID-19 ha tenido un gran impacto en los sistemas de salud. Muchas citas no urgentes se hicieron virtualmente para limitar riesgos de exposición. Objetivo: Evaluar el impacto de la pandemia en las pruebas para infecciones de transmisión sexual en servicios de salud universitarios. Materiales y métodos: Estudio cuantitativo del número de pruebas de infecciones de transmisión sexual realizadas, tasas de positividad y porcentaje de "cumplimiento de seguimiento" en el diagnóstico, desde marzo a diciembre del 2020 y su comparación con datos históricos (2015-2019) en los Servicios de Salud de UW-Madison. Resultados: Se encontró una reducción significativa en el número de pruebas realizadas y aumento de la tasa positiva, comparado con datos históricos para la muestra total y por sexo. Hubo disminución en el porcentaje de seguimiento para toda la muestra y para mujeres, y un incremento para hombres. Conclusiones: El análisis muestra reducciones significativas en pruebas para infecciones de transmisión sexual y seguimiento durante 2020, comparado con años anteriores y un incremento en la tasa de positividad. El hallazgo de una mayor positividad con un bajo número de pruebas se debe probablemente a la clasificación de los pacientes, facilitando así pruebas en aquellos con mayor riesgo.

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