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Nat Commun ; 15(1): 4278, 2024 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-38778039

RESUMO

Toxoplasma gondii is a global protozoan pathogen. Clonal lineages predominate in Europe, North America, Africa, and China, whereas highly recombinant parasites are endemic in South/Central America. Far East Asian T. gondii isolates are not included in current global population genetic structure analyses at WGS resolution. Here we report a genome-wide population study that compared eight Japanese and two Chinese isolates against representative worldwide T. gondii genomes using POPSICLE, a novel population structure analyzing software. Also included were 7 genomes resurrected from non-viable isolates by target enrichment sequencing. Visualization of the genome structure by POPSICLE shows a mixture of Chinese haplogroup (HG) 13 haploblocks introgressed within the genomes of Japanese HG2 and North American HG12. Furthermore, two ancestral lineages were identified in the Japanese strains; one lineage shares a common ancestor with HG11 found in both Japanese strains and North American HG12. The other ancestral lineage, found in T. gondii isolates from a small island in Japan, is admixed with genetically diversified South/Central American strains. Taken together, this study suggests multiple ancestral links between Far East Asian and American T. gondii strains and provides insight into the transmission history of this cosmopolitan organism.


Assuntos
Genoma de Protozoário , Filogenia , Toxoplasma , Toxoplasma/genética , Toxoplasma/classificação , Humanos , América do Norte , Genoma de Protozoário/genética , Toxoplasmose/parasitologia , China , América Central , Japão , Haplótipos , Variação Genética , Recombinação Genética
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