RESUMO
Noni is a fruit with potential medicinal use preventing elevated blood glucose levels in diabetes mellitus. Its effects have been attributed to an antioxidant property in several other diseases. However, the effects of noni-chronic supplementation on exercise performance in the presence of diabetes conditions are not known. Thirty-two male Wistar rats were used to verify the effects of chronic noni (Morinda citrifolia L) juice administration on glycemia, triglyceride levels, and its relation to physical performance. In addition, it was verified if chronic noni supplementation is safe for clinical use through kidney morphology analysis. In half of the rats, diabetes mellitus (DM) was induced with STZ. All rats were submitted to an incremental workload running test (IWT) until fatigued so that oxygen consumption and performance indexes (exercise time to fatigue and workload) could be analyzed before noni administration. Then, the control and DM groups received a placebo (saline solution) or noni juice (dilution 2:1) at a dose of 2 mL/kg once a day for 60 days. The result was four groups: control + placebo (CP), control + noni (CN), DM + placebo (DMP), and DM + noni (DMN). Our dose was based on in previous study by Nayak et al. (2011) that observed a significant reduction in glycemia with 2 ml/kg of the noni juice without any toxicity effect cited. Groups were then given a third IWT to verify the effect of the noni juice on exercise performance (exercise time to fatigue, workload, maximal oxygen consumption) and glycemia. Twenty-four hours after the third test, all animals were euthanized and blood and kidneys were removed for posterior analysis. The DM induction with STZ impaired the performance by 39%. Noni administration improved the time to fatigue and workload in DM rats beyond reducing hyperglycemia. These results could be associated with an improved energy efficiency promoted by noni ingestion, since the oxygen consumption was not different between the groups, although the exercise was longer in animals with noni ingestion. Our results provided evidence that chronic noni administration causes kidney damage since increased Bowman's space area in the control rats, suggesting glomerular hyperfiltration at the same magnitude as the non-treated DM group.In conclusion, chronic noni ingestion promoted glycemic control and improved the performance in DM rats but caused kidney toxicity.
RESUMO
PURPOSE: Verify the effects of concurrent training on cytokines in people living with HIV under antiretroviral therapy (ART) treatment. METHODS: This was a blinded, parallel-group, clinical trial, where 49 participants, divided in two groups, either control group or concurrent training group, took part in the intervention. The control group performed recreational activities and concurrent training group participated of 16-week, 3 times per week of heart rate guided-aerobic plus resistance training for major muscular groups. Cytokines (interleukins 4, 5, 6, 8, 10, tumor necrosis factor-α, interferon-γ, and granulocyte-macrophage colony-stimulating factor) were measured before and after 16-week experimental period using flow cytometry. RESULTS: From 49 participants who took part in the intervention, 28 completed the program and had data analyzed. There was a significant interaction for IL-8, which increased for control group: 7.1±5.1 vs. 8.1±6.0 and a decrease for concurrent training: 8.0±4.4 vs. 5.4±2.3. In addition, magnitude-based inference showed a likely beneficial effect for the training group when compared to the control group for IL-8, IL-5, and IL-10. The difference perceptual: mean and [CI 90%] between delta of difference within groups was -43.1 [-64.0 to -10.0] and -6.6 [-14.7 to 2.3], respectively. CONCLUSION: Short-term exercise is able to decrease the levels of IL-5, IL-8, and IL-10 in HIV-infected people undergoing ART.
Assuntos
Citocinas/sangue , Exercício Físico/fisiologia , Infecções por HIV/sangue , Feminino , Humanos , Mediadores da Inflamação/metabolismo , Masculino , Pessoa de Meia-Idade , Treinamento ResistidoRESUMO
RESUMO O treinamento físico é uma estratégia importante para a saúde de pessoas que vivem com HIV/AIDS; contudo, suas respostas a curto prazo ainda não foram amplamente estudadas, o que limita o entendimento dos efeitos e da segurança da prescrição do treinamento para essa população. Portanto, objetivou-se revisar sistematicamente as respostas agudas decorrentes do exercício físico em pessoas com HIV sobre variáveis fisiológicas e imunológicas. Para isso, foi realizada uma revisão sistemática a partir de trabalhos indexados nas seguintes bases de dados: Medline, Lilacs, Scielo, Web of Science e Science Direct. Os descritores utilizados foram: acquired immunodeficiency syndrome, HIV, AIDS, seropositive, acute session, short, physical activity, exercise, training. As buscas foram realizadas em fevereiro de 2015 e atualizadas em dezembro de 2015 e foram conduzidas sem restrição de datas de publicação ou idioma específico. Foram incluídos para esta revisão artigos que avaliaram as respostas agudas decorrentes de algum modelo de prescrição de treinamento físico envolvendo exercícios aeróbicos, com pesos ou combinados (exercícios aeróbicos e com pesos) relacionados com variáveis fisiológicas e imunológicas em pessoas infectadas pelo HIV. Foram encontrados 2.422 títulos, dos quais, após exclusão das duplicatas e a aplicação dos critérios de elegibilidade, foram selecionados sete artigos para síntese qualitativa. De acordo com os resultados reportados pelos estudos há evidências de que, imediatamente após a realização do exercício físico, ocorre um aumento do número de células circulantes, incluindo leucócitos totais, neutrófilos, monócitos e linfócitos T CD8+ em pessoas infectadas pelo HIV. Além disso, também se observaram alterações significantes nas concentrações de lactato, triglicerídeos, epinefrina e norepinefrina imediatamente após a realização do treinamento aeróbico, independentemente do uso de TARV e/ou de hiperlactatemia. No entanto, não há evidências suficientes para afirmar que o treinamento físico seja totalmente seguro e eficaz para esta população.
ABSTRACT Physical training is an important strategy for the health of people living with HIV/aids; however, its short-term responses have not yet been extensively studied, which limits the understanding of the effects and safety training prescription for this population. Therefore, we aimed to systematically review the acute responses resulting from physical exercise in people with HIV on physiological and immunological variables. For this, a systematic review was carried out from works indexed in the following databases: Medline, Lilacs, Scielo, Web of Science and Science Direct. The keywords used were acquired immunodeficiency syndrome, HIV, AIDS, seropositive, acute session, short, physical activity, exercise, training. The searches were conducted in February 2015 and updated in December 2015 and were conducted without restriction of publication dates or specific language. We included for this review articles that evaluated the acute responses derived from some model of prescription of physical training involving aerobic, weight or combined exercises (aerobic and weight exercises) related to physiological and immunological variables in HIV infected individuals. We found 2,422 titles of which, after exclusion of the duplicates and the application of the eligibility criteria, seven articles were selected for qualitative synthesis. According to the results reported by the studies, there is evidence that immediately after physical exercise an increase in the number of circulating cells occurs, including total leukocytes, neutrophils, monocytes and T CD8+ lymphocytes in HIV-infected people. Furthermore, significant changes in the concentrations of lactate, triglycerides, epinephrine and norepinephrine were also observed immediately after aerobic training regardless the use of HAART and/or hyperlactatemia. However, there is insufficient evidence to state that physical training is totally safe and effective for this population.
RESUMEN El entrenamiento físico es una estrategia importante para la salud de las personas que viven con el VIH/SIDA. Sin embargo, sus respuestas a corto plazo no han sido ampliamente estudiadas, lo que limita la comprensión de los efectos y la seguridad de la prescripción de entrenamiento para esta población. Por lo tanto, el objetivo fue revisar sistemáticamente las respuestas agudas al ejercicio en personas con VIH en las variables fisiológicas e inmunológicas. Para esto, se realizó una revisión sistemática de artículos indexados en las siguientes bases de datos: Medline, Lilacs, Scielo, Web of Science y Science Direct. Los descriptores utilizados fueron: acquired immunodeficiency syndrome, HIV, AIDS, seropositive, acute session, short, physical activity, exercise, training. Las búsquedas se realizaron en febrero de 2015 y fueron actualizadas en diciembre de 2015, siendo llevadas a cabo sin restricciones de fecha de publicación o idioma específico. Se seleccionaran en esta revisión los artículos que evaluaron las respuestas agudas de algún modelo de entrenamiento físico que implica la prescripción de ejercicios aeróbicos, con pesas o combinados (práctica de ejercicio aeróbico y pesas) relacionadas con variables fisiológicas e inmunológicas en las personas con VIH. Se encontraron 2.422 títulos, de los cuales, después de la exclusión de duplicados y la aplicación de los criterios de elegibilidad, se seleccionaron siete artículos para síntesis cualitativa. De acuerdo con los resultados reportados por estudios hay pruebas de que inmediatamente después del ejercicio hay un aumento en el número de células circulantes, incluyendo leucocitos totales, neutrófilos, monocitos y linfocitos T CD8+ en individuos infectados por el VIH. Además, se observaron cambios significativos en las concentraciones de lactato, triglicéridos, epinefrina y norepinefrina inmediatamente después del entrenamiento aeróbico, independientemente del uso de HAART y/o hiperlactatemia. Sin embargo, no hay pruebas suficientes para afirmar que el entrenamiento físico es completamente seguro y eficaz para esta población.