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OBJECTIVE: To analyze the validity evidence of the Brazilian version of the Cancer Behavior Inventory - Brief Version. METHOD: Methodological study, conducted between November and December 2021, with 140 patients undergoing hospital cancer treatment in João Pessoa, Paraíba, Brazil. Psychometric analyses were performed in the adapted version, using exploratory factor analysis and correlation with correlated constructs. RESULTS: A two-factor and 10-item model was evidenced. The cumulative variance explained about 61% the shared variance of the items. Satisfactory values were observed for the factors in the analyses of composite reliability (0.89 and 0.91, respectively), internal consistency (0.86 and 0.91, respectively) and ORION (0.89 and 0.85, respectively). The expected correlations of self-efficacy with quality of life (convergent) and with anxiety and depression (divergent) were evident. CONCLUSION: The Brazilian version of the instrument showed evidence of validity, being considered reliable to assess the self-efficacy of patients undergoing cancer treatment.
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Neoplasias , Qualidade de Vida , Humanos , Brasil , Reprodutibilidade dos Testes , Ansiedade/diagnóstico , Ansiedade/etiologia , Psicometria , Inquéritos e QuestionáriosRESUMO
ABSTRACT Objective: To analyze the validity evidence of the Brazilian version of the Cancer Behavior Inventory - Brief Version. Method: Methodological study, conducted between November and December 2021, with 140 patients undergoing hospital cancer treatment in João Pessoa, Paraíba, Brazil. Psychometric analyses were performed in the adapted version, using exploratory factor analysis and correlation with correlated constructs. Results: A two-factor and 10-item model was evidenced. The cumulative variance explained about 61% the shared variance of the items. Satisfactory values were observed for the factors in the analyses of composite reliability (0.89 and 0.91, respectively), internal consistency (0.86 and 0.91, respectively) and ORION (0.89 and 0.85, respectively). The expected correlations of self-efficacy with quality of life (convergent) and with anxiety and depression (divergent) were evident. Conclusion: The Brazilian version of the instrument showed evidence of validity, being considered reliable to assess the self-efficacy of patients undergoing cancer treatment.
RESUMEN Objetivo: Analizar las evidencias de validez de la versión brasileña del Cancer Behavior Inventory - Brief Version. Método: Estudio metodológico, realizado entre noviembre y diciembre de 2021, con 140 pacientes en tratamiento oncológico hospitalario en João Pessoa, Paraíba, Brasil. Se realizaron análisis psicométricos en la versión adaptada, mediante análisis factorial exploratorio y correlación con constructos correlacionados. Resultados: Se evidenció un modelo de 2 factores y 10 ítems. La varianza acumulada explicó alrededor del 61% de la varianza compartida de los ítems. Se observaron valores satisfactorios para los factores en el análisis de confiabilidad compuesta (0,89 y 0,91, respectivamente), consistencia interna (0,86 y 0,91, respectivamente) y ORION (0,89 y 0,85, respectivamente). Se evidenciaron las correlaciones esperadas de la autoeficacia con la calidad de vida (convergente) y con la ansiedad y la depresión (divergente). Conclusión: La versión brasileña del instrumento mostró evidencias de validez, siendo considerado confiable para evaluar la autoeficacia de pacientes en tratamiento oncológico.
RESUMO Objetivo: Analisar as evidências de validade da versão brasileira do Cancer Behavior Inventory - Brief Version. Método: Estudo metodológico, realizado entre os meses de novembro e dezembro de 2021, com 140 pacientes em tratamento oncológico hospitalar em João Pessoa, Paraíba, Brasil. Foram realizadas análises psicométricas na versão adaptada, mediante a análise fatorial exploratória e correlação com constructos correlacionados. Resultados: Evidenciou-se um modelo de 2 fatores e 10 itens. A variância acumulada explicou cerca de 61% da variância compartilhada dos itens. Foram observados valores satisfatórios para os fatores nas análises de confiabilidade composta (0,89 e 0,91, respectivamente), consistência interna (0,86 e 0,91, respectivamente) e ORION (0,89 e 0,85, respectivamente). Evidenciaram-se as correlações esperadas da autoeficácia com a qualidade de vida (convergente) e com a ansiedade e depressão (divergente). Conclusão: A versão brasileira do instrumento mostrou evidências de validade, sendo considerada como confiável para avaliar a autoeficácia dos pacientes em tratamento oncológico.
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This study aimed to gather evidence on the adequacy of the General Health Questionnaire (GHQ-12) in Brazil, considering a random sample of Brazilian physicians. Specifically aimed: (1) to test the GHQ-12 bifactor structure compared to alternative models, (2) to check its factorial invariance regarding to gender and the diagnosis of mental and behavioral disorders, and (3) to know the association of this measure with indicators of poor health (e.g., suicidal thoughts, decreased libido, medication use). The study included 1,085 physicians with a mean age of 45.7 (SD = 10.6), mostly male (61.5%), married (72.6%) and Catholic (59.2%). They answered the GHQ-12, the Positive and Negative Suicidal Ideation Inventory, and demographic questions. The best fit model was the bifactor structure composed of anxiety and depression, in addition to a general dimension, which presented Cronbach's alpha, McDonald's ω and composite reliability higher than 0.70 just for a general fact. Psychological distress scores correlated with suicidal ideation and indicators of health and sexual satisfaction. This is a psychometrically suitable instrument that can be used in terms of its total, but its specific factors need to be used with caution.
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Transtornos de Ansiedade , Ansiedade , Humanos , Masculino , Pessoa de Meia-Idade , Feminino , Reprodutibilidade dos Testes , Inquéritos e Questionários , Ansiedade/psicologia , Nível de Saúde , PsicometriaRESUMO
Abstract This study aimed to gather evidence on the adequacy of the General Health Questionnaire (GHQ-12) in Brazil, considering a random sample of Brazilian physicians. Specifically aimed: (1) to test the GHQ-12 bifactor structure compared to alternative models, (2) to check its factorial invariance regarding to gender and the diagnosis of mental and behavioral disorders, and (3) to know the association of this measure with indicators of poor health (e.g., suicidal thoughts, decreased libido, medication use). The study included 1,085 physicians with a mean age of 45.7 (SD = 10.6), mostly male (61.5%), married (72.6%) and Catholic (59.2%). They answered the GHQ-12, the Positive and Negative Suicidal Ideation Inventory, and demographic questions. The best fit model was the bifactor structure composed of anxiety and depression, in addition to a general dimension, which presented Cronbach's alpha, McDonald's ω and composite reliability higher than 0.70 just for a general fact. Psychological distress scores correlated with suicidal ideation and indicators of health and sexual satisfaction. This is a psychometrically suitable instrument that can be used in terms of its total, but its specific factors need to be used with caution.
Resumo Este estudo teve como objetivo reunir evidências sobre a adequação do Questionário de Saúde Geral (QSG-12) no Brasil, considerando uma amostra aleatória de médicos brasileiros. Especificamente, objetivou-se: (1) testar uma estrutura bifactor em comparação com modelos alternativos, (2) verificar invariância fatorial em relação ao gênero e ao diagnóstico de transtornos mentais e comportamentais, e (3) conhecer a associação com indicadores de saúde precária (por exemplo: pensamentos suicidas, diminuição da libido e uso de medicamentos). Participaram do estudo 1.085 médicos, com média de idade de 45,7 (DP = 10,6), maioria de sexo masculino (61,5%), casados (72,6%) e católicos (59,2%). Eles responderam ao QSG-12, ao Inventário de Ideação Suicida Positiva e Negativa e a questões demográficas. O modelo de melhor ajuste foi a estrutura bifactor (composta por ansiedade, depressão e uma dimensão geral), que apresentou alfa de Cronbach, ômega de McDonald e confiabilidade composta superior a 0,70 apenas para o fato geral. Pontuações de sofrimento psicológico se correlacionaram a ideação suicida e indicadores negativos de saúde e satisfação sexual. O instrumento foi psicometricamente adequado e pode ser utilizado em termos de sua pontuação total, mas seus fatores específicos precisam ser utilizados com cautela.
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O presente estudo teve como objetivo verificar os correlatos sociodemográficos da ideação suicida em uma amostra de paraibanos. O estudo contou com 215 participantes, com média de idade de 24,16 anos (DP= 8,02). A coleta foi realizada por meio de um questionário online divulgado nas redes sociais. Foram dispostas cinco questões relativas à ideação suicida, com respostas tipo Likert, além de um questionário sociodemográfico. Verificou-se que as pessoas que não trabalham, que não possuem filhos e que são solteiras apresentaram maior média de ideação suicida. Além disto, a ideação suicida aumentou para as pessoas de menor idade, menos anos de estudo e menor compromisso religioso. Estes resultados foram estatisticamente significativos (p < 0,05). Salienta-se que essa pesquisa não possui uma amostra representativa, mas pode guiar estudos mais robustos para investigar diferenças de ideação suicida entre grupos sociodemográficos.(AU)
The presente study aimed to verify the sociodemographic correlates of suicidal ideation in a sample of paraibanos. The study involved 215 participants, with a mean age of 24-16 years (SD = 8,02). The collection was carried through an online questionnaire disseminated on social networks. Five questions were asked regarding suicidal ideation, with Likert-type answers, in addition to a sociodemographic questionnaire. It was found that people who do not work, who do not have children and who are single had a higher mean of suicidal ideation. In addition, suicidal ideation has increased for younger people, with less years of study and less religious commitment. These results were statistically significant (p ≤ 0,05). It should be noted that this research does not have a representative sample, but it can guide more robust studies to investigate differences in suicidal ideation between sociodemographic groups.(AU)
El presente estudio tuvo como objetivo verificar los correlatos sociodemográficos de la ideación suicidio en una muestra de paraibanos. El estudio contó 215 participantes, con una edad media de 24,16 años (DE = 8,02). La recogida se llevó a cabo a través de un cuestionario en línea disponible en un enlace y difundido em las redes sociales. Se hicieron cinco preguntas sobre la ideación suicida, con respuestas tipo Likert, además de un cuestionario sociodemográfico. Se encontró que las personas que no trabajan, que no tienen hijos y que son solteros tuvieron un promedio más alto de ideación suicida. Además, la ideación suicida ha aumentado para las personas de menor edad, menos años de estudio y menos compromiso religioso. Estos resultados fueron estatiscamente significante (p ≤ 0,05). Cabe destacar que esta investigación no tiene una muestra representativa, pero puede orientar estudios más robustos para investigar diferencias en la ideación suicida entre grupos sociodemográficos.(AU)
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Humanos , Adulto , Ideação Suicida , Fatores Sociodemográficos , Saúde MentalRESUMO
Glioblastoma is the most common and aggressive primary brain tumor, characterized by its high chemoresistance and the presence of a cell subpopulation that persists under hypoxic niches, called glioblastoma stem-like cells (GSCs). The chemoresistance of GSCs is mediated in part by adenosine signaling and ABC transporters, which extrude drugs outside the cell, such as the multidrug resistance-associated proteins (MRPs) subfamily. Adenosine promotes MRP1-dependent chemoresistance under normoxia. However, adenosine/MRPs-dependent chemoresistance under hypoxia has not been studied until now. Transcript and protein levels were determined by RT-qPCR and Western blot, respectively. MRP extrusion capacity was determined by intracellular 5 (6)-Carboxyfluorescein diacetate (CFDA) accumulation. Cell viability was measured by MTS assays. Cell cycle and apoptosis were determined by flow cytometry. Here, we show for the first time that MRP3 expression is induced under hypoxia through the A2B adenosine receptor. Hypoxia enhances MRP-dependent extrusion capacity and the chemoresistance of GSCs. Meanwhile, MRP3 knockdown decreases GSC viability under hypoxia. Downregulation of the A2B receptor decreases MRP3 expression and chemosensibilizes GSCs treated with teniposide under hypoxia. These data suggest that hypoxia-dependent activation of A2B adenosine receptor promotes survival of GSCs through MRP3 induction.
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Neoplasias Encefálicas , Glioblastoma , Proteínas Associadas à Resistência a Múltiplos Medicamentos , Adenosina/metabolismo , Neoplasias Encefálicas/metabolismo , Resistencia a Medicamentos Antineoplásicos , Glioblastoma/metabolismo , Humanos , Hipóxia/metabolismo , Proteínas Associadas à Resistência a Múltiplos Medicamentos/metabolismo , Células-Tronco Neoplásicas/metabolismo , Receptor A2B de Adenosina/metabolismo , Receptores Purinérgicos P1/metabolismoRESUMO
Resumo Objetivo Analisar a educação sexual, comportamentos de risco e atitudes de universitários usuários de aplicativos de encontros, considerando a orientação sexual. Métodos Trata-se de um estudo de natureza quantitativa, transversal e descritivo, com uma amostra não probabilística de conveniência, constituída por 359 universitários da região norte do Brasil. Utilizou-se um questionário com informações sobre dados sociodemográficos, uso de aplicativos de encontros, fontes de informações sobre sexo seguro, comportamentos de risco e atitudes. Foram realizadas análises bivariadas e análise de variância com testes post-hoc de Bonferroni. Resultados Homossexuais (92,3%) e bissexuais (84,9%) reportaram o uso de aplicativos e tiveram encontro com parceiro casual (p<0,05). O Tinder foi o aplicativo acessado por 93,58% dos usuários. Não houve diferença para a prática sexual, sexo desprotegido e múltiplos parceiros sexuais. Informações sobre sexo seguro e infecções sexualmente transmissíveis por meio dos aplicativos foi reportada por homossexuais (61,1%) (p<0,05). Bissexuais (22,2%) vivenciaram a educação sexual nos eventos científicos e heterossexuais (38,2%) recorreram aos amigos universitários (p<0,05). Homossexuais (88,9%) acessaram o serviço do Centro de Testagem e Aconselhamento e 72,4% realizaram a testagem para infecções sexualmente transmissíveis após a prática sexual com parceiro casual (p<0,05). As atitudes positivas para a saúde sexual foram observadas nos heterossexuais não usuários de aplicativos de encontros. Conclusão A vulnerabilidade dos usuários de aplicativos de encontros não esteve associada com a orientação sexual. Intervenções por meio da educação sexual que estimulem o autoconhecimento e os riscos da prática sexual desprotegida são requeridas frente ao acesso às tecnologias para encontros casuais.
Resumen Objetivo Analizar la educación sexual, comportamientos de riesgo y actitudes de estudiantes universitarios usuarios de aplicaciones de citas, considerando la orientación sexual. Métodos Se trata de un estudio de naturaleza cuantitativa, transversal y descriptiva, con una muestra no probabilística de conveniencia, constituida por 359 estudiantes universitarios de la región norte de Brasil. Se utilizó un cuestionario con información sobre datos sociodemográficos, uso de aplicaciones de citas, fuentes de información sobre sexo seguro, comportamientos de riesgo y actitudes. Se realizaron análisis bivariados y análisis de varianza con ensayos post-hoc de Bonferroni. Resultados Homosexuales (92,3 %) y bisexuales (84,9 %) refirieron el uso de aplicaciones y tuvieron citas con pareja casual (p<0,05). Tinder fue la aplicación a la que el 93,58 % de los usuarios accedió. No hubo diferencias en la práctica sexual, sexo desprotegido y múltiples parejas sexuales. Información sobre sexo seguro y sobre infecciones de transmisión sexual por medio de las aplicaciones fue reportada por homosexuales (61,1 %) (p<0,05). Bisexuales (22,2 %) vivieron la educación sexual en los eventos científicos, y heterosexuales (38,2 %) recurrieron a sus amigos de la universidad (p<0,05). Homosexuales (88,9 %) accedieron al servicio del Centro de Testeo y de Consejo, y el 72,4 % realizó el testeo de infecciones sexualmente transmisibles después de la práctica sexual con pareja casual (p<0,05). Se observaron actitudes positivas hacia la salud sexual en los heterosexuales no usuarios de aplicaciones de citas. Conclusión La vulnerabilidad de los usuarios de aplicaciones de citas no estuvo asociada con la orientación sexual. Son necesarias intervenciones por medio de la educación sexual que estimulen el autoconocimiento y los riesgos de la práctica sexual desprotegida ante el acceso a las tecnologías para citas casuales.
Abstract Objective To analyze sex education, risk behaviors and attitudes of college students who use dating applications, considering their sexual orientation. Methods This is a quantitative, cross-sectional and descriptive study, with a non-probabilistic convenience sample, consisting of 359 college students from northern Brazil. A questionnaire was used with information on sociodemographic data, use of dating applications, sources of information on protected sex, risk behaviors and attitudes. Bivariate analyzes and analysis of variance with Bonferroni's post-hoc tests were performed. Results Homosexuals (92.3%) and bisexuals (84.9%) reported using applications and meeting with casual partners (p<0.05). Tinder was the application accessed by 93.58% of users. There was no difference for sexual practice, unprotected sex and multiple sexual partners. Information about protected sex and sexually transmitted infections through the applications was reported by homosexuals (61.1%) (p<0.05). Bisexuals (22.2%) experienced sex education in scientific events and heterosexuals (38.2%) turned to college friends (p<0.05). Homosexuals (88.9%) accessed the Testing and Counseling Center service and 72.4% were tested for sexually transmitted infections after having sex with a casual partner (p<0.05). Positive attitudes towards sexual health were observed in heterosexual non-dating application users. Conclusion Vulnerability of dating application users was not associated with sexual orientation. Interventions through sex education that stimulate self-knowledge and the risks of unprotected sexual practice are required in view of access to technologies for casual dates.
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Humanos , Masculino , Feminino , Adolescente , Adulto , Comportamento Sexual , Educação Sexual , Conscientização , Aplicativos Móveis , Comportamentos de Risco à Saúde , Vulnerabilidade Sexual , Epidemiologia Descritiva , Estudos TransversaisRESUMO
A large number of experimental studies has demonstrated that angiotensin II (Ang II) is involved in key events of the inflammatory process. This study aimed to evaluate the role of Ang II type 1 (AT1) and Ang II type 2 (AT2) receptors on periodontitis. Methods: Experimental periodontitis was induced by placing a 5.0 nylon thread ligature around the second upper left molar of AT1 mice, no-ligature or ligature (AT1-NL and AT1-L), AT2 (AT2-NL or AT2-L) and wild type (WT-NL or L). Alveolar bone loss was scanned using Micro-CT. Cytokines, peptides and enzymes were analyzed from gingival tissues by Elisa and RT-PCR. Results: The blockade of AT1 receptor resulted in bone loss, even in healthy animals. Ang II receptor blockades did not prevent linear bone loss. Ang II and Ang 1-7 levels were significantly increased in the AT2-L (p < 0.01) group compared to AT2-NL and AT1-L. The genic expression of the Mas receptor was significantly increased in WT-L and AT2-L compared to (WT-NL and AT2-NL, respectively) and in AT1-L. Conclusions: Our data suggest that the receptor AT1 appears to be important for the maintenance of bone mass. AT2 receptor molecular function in periodontitis appears to be regulated by AT1.
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Perda do Osso Alveolar/metabolismo , Doenças Mandibulares/metabolismo , Periodontite/metabolismo , Receptor Tipo 1 de Angiotensina/metabolismo , Receptor Tipo 2 de Angiotensina/metabolismo , Perda do Osso Alveolar/genética , Perda do Osso Alveolar/patologia , Angiotensina II/metabolismo , Animais , Modelos Animais de Doenças , Masculino , Doenças Mandibulares/genética , Doenças Mandibulares/patologia , Camundongos , Camundongos Knockout , Periodontite/genética , Periodontite/patologia , Receptor Tipo 1 de Angiotensina/genética , Receptor Tipo 2 de Angiotensina/genéticaRESUMO
The article aims to evaluate the effects that empathy, altruism and compassion, plus sociodemographic variables, have on the permanence of adherence to the social isolation demanded by the Covid-19 pandemic. The study was quantitative, longitudinal and included a sample of 200 people from three Brazilian states, who answered twice an online questionnaire (prepared by Google forms), at intervals of 30 days, during social isolation. Davis' Multidimensional Reactivity Scale was used; the Santa Clara compassion scale (Brief Compassion Scale); the Altruistic Attitudes Scale and a sociodemographic questionnaire. The results indicated that there was an increase in the perspective empathy dimension between the first and the second collection and that the financial aspects, compassion and perspective taking increased the chances of people remaining in social isolation.
O artigo possui como objetivo avaliar o efeito que a empatia, altruísmo e compaixão, mais variáveis sociodemográficas, possuem na permanência da adesão ao isolamento social demandado pela pandemia do Covid-19. O estudo foi quantitativo, longitudinal e contou com uma amostra de 200 pessoas de três estados brasileiros, que responderam duas vezes um questionário online (elaborado pelo Google forms), em intervalos de 30 dias, durante o isolamento social do primeiro semestre de 2020. Utilizou-se a escala Multidimensional de Reatividade Interpessoal de Davis; a escala de compaixão da Santa Clara (Brief Compassion Scale); a Escala de Atitudes Altruístas e um questionário sociodemográfico. Os resultados indicaram que houve aumento na dimensão da empatia de tomada de perspectiva entre a primeira e a segunda coleta e que os aspectos financeiros, a compaixão e a tomada de perspectiva aumentaram as chances de as pessoas permanecerem em isolamento social.
El artículo tiene como objetivo evaluar los efectos que la empatía, el altruismo y la compasión, además de las variables sociodemográficas, tienen sobre la permanencia de la adhesión al aislamiento social exigido por la pandemia de Covid-19. El estudio fue cuantitativo, longitudinal e incluyó una muestra de 200 personas de tres estados brasileños, que respondieron dos veces un cuestionario en línea (preparado por formularios de Google), a intervalos de 30 días, durante el aislamiento social. Se utilizó la escala de reactividad multidimensional de Davis; la escala de compasión de Santa Clara (Breve escala de compasión); la escala de actitudes altruistas y un cuestionario sociodemográfico. Los resultados indicaron que hubo un aumento en la dimensión de empatía de perspectiva entre la primera y la segunda colección y que los aspectos financieros, la compasión y la toma de perspectiva aumentaron las posibilidades de que las personas permanezcan en aislamiento social.
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Humanos , Empatia , COVID-19 , Isolamento Social , Brasil , AltruísmoRESUMO
Although dating applications (apps) have become popular among young adults, there is a dearth of information regarding the sexual health implications among Brazilian college students. This study examined risky sexual behavior and attitudes of dating app users, based on their sex in Brazil's Legal Amazon. Three hundred and fifty-nine students reported their sociodemographic data, dating app use, and sexual behaviors and attitudes through self-administered questionnaires. Bivariate analyses and analysis of variance (ANOVA) with Bonferroni post-hoc tests were performed. Dating app use was reported by 238 (66.3%) subjects, most of whom had an encounter and sex with a casual partner. Women frequently requested condom use. Trust in one's partner or having repeated encounters were the main reasons for engaging in risky sexual behavior. Men had a greater number of sexual partners and less protective attitudes. Sexual health awareness by apps was not reported by 97% of women, and most of them were not tested for sexually transmitted infections. A positive attitude toward sexual health was not a predictor of safe sex. Important similarities and differences regarding risky sexual behaviors and attitudes were observed between the sexes, many of which correlated with increased sexual vulnerability during the sexual encounters arranged through the dating apps. This cross-sectional study supports efforts on sexual health promotion and sexual education implementation in the face of growing usage of apps among young adults for sexual matters.