RESUMO
Antimicrobial resistance is a global health threat. Misuse and overuse of antimicrobials are the main drivers in developing drug-resistant bacteria. The emergence of the rapid global spread of multi-resistant bacteria requires urgent multisectoral action to generate novel treatment alternatives. Combination therapy offers the potential to exploit synergistic effects for enhanced antibacterial efficacy of drugs. Understanding the complex dynamics and kinetics of drug interactions in combination therapy is crucial. Therefore, this review outlines the current advances in antibiotic resistance's evolutionary and genetic dynamics in combination therapies-exposed bacteria. Moreover, we also discussed four pivotal future research areas to comprehend better the development of antibiotic resistance in bacteria treated with combination strategies.
RESUMO
Several studies have assessed crop water requirements based on soil properties, but these have been on a small scale or on soils with similar textures. Here, a data base of soil measurements in the field and laboratory from sites across Irrigation District 023, San Juan del Rio, Queretaro, Mexico was sampled, collected, analyzed, and integrated. The data base, named, NaneSoil, contains information on 900 samples obtained from irrigated plots. NaneSoil cover 10 of the 12 textural classes with the following information: sand, silt, clay contents, bulk density, saturated volumetric water content, field capacity, permanent wilting point and saturated hydraulic conductivity. The aim of this work is to provide the scientific community with sufficient information to perform a large number of analyses, for example, development of pedotransfer functions, calculation of water requirements of plants in soils with similar characteristics, modeling of infiltration, optimal irrigation discharge calculation, among others. The dataset also promotes the scientific community to contribute their own measurements to further strengthen the knowledge of flow in the porous medium.