RESUMO
OBJECTIVE: The purpose of this study was to evaluate influence of topical sodium alendronate (ALN), photodynamic therapy (aPDT), or a combination thereof as adjuvant to scaling and root planing (SRP) in the treatment of experimental periodontitis in rats. BACKGROUND: Therapeutic protocols to control periodontitis progression that aim to equalize bacterial action and load with tissue immune response are well addressed in current scientific research. METHODS: Experimental periodontitis was induced in 96 rats with a ligature around the mandibular left first molar. After 7 days, ligature was removed and animals were treated according to the following experimental groups (n = 8): control-SRP plus saline solution; ALN-SRP plus ALN; aPDT-SRP plus methylene blue irrigation, followed by low-level laser therapy (LLLT); and ALN/aPDT-SRP plus ALN and methylene blue irrigation followed by LLLT. The animals were euthanized at 7, 15, and 30 days after treatments. Collagen maturation (picrosirius red staining) and immunohistochemical analyses (TRAP, RANKL and osteoprotegerin [OPG]) were performed. Data were submitted to statistical analysis (P < .05). RESULTS: At 7 days, group ALN presented a significantly higher number of TRAP-positive cells and percentage of immature collagen fibers than group ALN/aPDT, while group ALN/aPDT presented a significantly higher percentage of mature collagen fibers than group ALN. At 30 days, group ALN presented significantly lower percentage of immature collagen fibers and higher percentage of mature collagen fibers than control. CONCLUSION: It can be concluded that topical use of ALN coadjutant to SRP, alone or combined with aPDT, enhanced collagen maturation and reduced osteoclastogenesis during the healing of experimental periodontitis.
Assuntos
Alendronato , Raspagem Dentária , Fotoquimioterapia , Aplainamento Radicular , Alendronato/administração & dosagem , Animais , Terapia Combinada , Ratos , Ratos Wistar , SódioRESUMO
CONTEXT: Is it possible that the irrigating solutions can have the potential to cause post-operative pain? Unfortunately, the current literature does not provide clear guidance. AIM: The purpose of this systematic review and meta-analysis was to comprehensively review two different irrigation solutions (sodium hypochlorite and chlorhexidine) regarding the post-operative pain after endodontic treatment. SETTINGS AND DESIGN: This study was prepared according to the Cochrane criteria for creating a systematic review and meta-analysis and confirms the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. MATERIAL AND METHODS: This search was conducted in the PubMed/MEDLINE, SCOPUS and Cochrane Library databases until February 2018 to answer the In [(Population) what is the effect of (Intervention) on (Outcome), compared with (Comparison) Intervention] (PICO) question: could sodium hypochlorite cause more post-operative pain than chlorhexidine in teeth subjected to endodontic treatment? The primary outcome was overall post-operative pain after 24 h. RESULTS: After applying the inclusion and exclusion criteria, three randomized clinical trials fulfilled the eligibility criteria, and two were subjected to the meta-analysis. There was no difference in post-operative pain between the tested irrigating solutions. CONCLUSIONS: There are few studies published in the current literature; therefore, additional randomized clinical studies are required to on this topic to help clinicians make the best decision concerning treatment.
Assuntos
Anti-Infecciosos , Endodontia , Clorexidina , Humanos , Dor Pós-Operatória/tratamento farmacológico , Dor Pós-Operatória/prevenção & controle , Ensaios Clínicos Controlados Aleatórios como Assunto , Hipoclorito de SódioRESUMO
BACKGROUND: Endodontic infections require the use of root canal dressings to reduce microorganisms, and studies of new intracanal medications are common. Two experimental intracanal medications that contain antibiotics and chlorhexidine have been proposed. However, given the composition of these medications, tooth discoloration with subsequent impacts on aesthetic parameters is a concern. The objective of this study is to evaluate tooth discoloration after the use of experimental intracanal medications for up to 180 days. METHODS: Thirty extracted bovine teeth were divided into 3 groups according to intracanal medication as follows: group I: experimental intracanal medication 1; group II: experimental intracanal medication 2; and group III: no medication (negative control). Color change was assessed using a spectrophotometer on day 0 (before the placement of the material); daily until the seventh day; and 8, 15, 60 and 180 days after removal of the medications. The values obtained were compared using ANOVA and Tukey's tests at a significance level of 5% (P<0.05). RESULTS: Up to 60 days after the removal of the medication, the teeth did not exhibit color changes. However, at 180 days, compared with the other medications, experimental intracanal medication 2 significantly promoted tooth staining (P<0.05). CONCLUSIONS: In contrast to experimental intracanal medication 2, intracanal medication 1 did not promote tooth discoloration.