RESUMO
The aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (ESSDAI) and subjective (ESSPRI) indexes in patients with primary Sjögren's Syndrome (pSS). Twenty-eight female patients were divided into four groups: pSS patients with or without chronic periodontitis (SCP, SC, respectively), and systemically healthy patients with or without chronic periodontitis (CP, C, respectively). Periodontal clinical examination and immunological and microbiological sample collection were performed at baseline, 30 and 90 days after nonsurgical periodontal treatment (NSPT). Levels of interleukin IL-1ß, IL-8 and IL-10 in saliva and gingival crevicular fluid (GCF) were evaluated by ELISA, as well as the expression of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans, (Aa) Tannerella forsythia (Tf), and Treponema denticola (Td), by qPCR. Systemic activity and pSS symptoms were evaluated by ESSDAI and ESSPRI. NSPT resulted in improved periodontal clinical parameters in both SCP and CP groups (p>0.05). Pg, Aa, and Tf levels decreased after NSPT only in CP patients (p<0.05). Significantly greater levels of IL-10 in GCF were verified in both SCP and CP groups (p<0.05). SCP patients showed increased salivary flow rates and decreased ESSPRI scores after NSPT. In conclusion, NSPT in pSS patients resulted in improved clinical and immunological parameters, with no significant effects on microbiological status. pSS patients also showed increased salivary flow and lower ESSPRI scores after therapy. Therefore, it can be suggested that NSPT may improve the quality of life of pSS patients.
Assuntos
Periodontite Crônica/etiologia , Periodontite Crônica/terapia , Síndrome de Sjogren/complicações , Adolescente , Adulto , Idoso , Carga Bacteriana , Estudos de Casos e Controles , Periodontite Crônica/microbiologia , Periodontite Crônica/fisiopatologia , Ensaio de Imunoadsorção Enzimática , Feminino , Líquido do Sulco Gengival , Humanos , Interleucinas/análise , Estudos Longitudinais , Pessoa de Meia-Idade , Reação em Cadeia da Polimerase , Estudos Prospectivos , Saliva/química , Salivação/fisiologia , Taxa Secretória , Síndrome de Sjogren/fisiopatologia , Fatores de Tempo , Resultado do Tratamento , Adulto JovemRESUMO
Abstract The aim of this longitudinal prospective study was to evaluate the effects of periodontal treatment on the clinical, microbiological and immunological periodontal parameters, and on the systemic activity (ESSDAI) and subjective (ESSPRI) indexes in patients with primary Sjögren’s Syndrome (pSS). Twenty-eight female patients were divided into four groups: pSS patients with or without chronic periodontitis (SCP, SC, respectively), and systemically healthy patients with or without chronic periodontitis (CP, C, respectively). Periodontal clinical examination and immunological and microbiological sample collection were performed at baseline, 30 and 90 days after nonsurgical periodontal treatment (NSPT). Levels of interleukin IL-1β, IL-8 and IL-10 in saliva and gingival crevicular fluid (GCF) were evaluated by ELISA, as well as the expression of Porphyromonas gingivalis (Pg), Aggregatibacter actinomycetemcomitans, (Aa) Tannerella forsythia (Tf), and Treponema denticola (Td), by qPCR. Systemic activity and pSS symptoms were evaluated by ESSDAI and ESSPRI. NSPT resulted in improved periodontal clinical parameters in both SCP and CP groups (p>0.05). Pg, Aa, and Tf levels decreased after NSPT only in CP patients (p<0.05). Significantly greater levels of IL-10 in GCF were verified in both SCP and CP groups (p<0.05). SCP patients showed increased salivary flow rates and decreased ESSPRI scores after NSPT. In conclusion, NSPT in pSS patients resulted in improved clinical and immunological parameters, with no significant effects on microbiological status. pSS patients also showed increased salivary flow and lower ESSPRI scores after therapy. Therefore, it can be suggested that NSPT may improve the quality of life of pSS patients.
Assuntos
Humanos , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Síndrome de Sjogren/complicações , Periodontite Crônica/etiologia , Periodontite Crônica/terapia , Saliva/química , Salivação/fisiologia , Taxa Secretória , Fatores de Tempo , Ensaio de Imunoadsorção Enzimática , Síndrome de Sjogren/fisiopatologia , Estudos de Casos e Controles , Reação em Cadeia da Polimerase , Estudos Prospectivos , Estudos Longitudinais , Líquido do Sulco Gengival , Interleucinas/análise , Resultado do Tratamento , Periodontite Crônica/fisiopatologia , Periodontite Crônica/microbiologia , Carga BacterianaRESUMO
Objective. The brown tumour of hyperparathyroidism is a result of a metabolic disorder caused by primary hyperparathyroidism. Report. We described a case of a 37-year-old female patient presenting bimaxillary intraoral lesions and swelling in the neck. Incisional biopsy of the oral lesion was performed and histopathological examination revealed a central giant cell lesion composed by intense haemorrhagic exudate, abundant presence of giant cells, and areas with hemosiderin pigment. The patient also presented high levels of serum calcium and parathyroid hormone, hyperfunctioning parathyroid tissue, bilateral parenchymal nephropathy, and densitometry lower than expected, showing an advanced stage of osteitis fibrosa cystica. Synchronous parathyroid adenoma and papillary thyroid carcinoma were confirmed by imaging exams and histopathologically. Conclusion. The composition of all the clinical, pathological, and imaging findings led to the final diagnosis of brown tumour of hyperparathyroidism. The occurrence of parathyroid adenoma, papillary thyroid carcinoma, and brown tumours of hyperparathyroidism in their late stage (osteitis fibrosa cystica) associated with oral brown tumours involving the mandible and maxilla is extremely rare.
RESUMO
OBJECTIVE: The objective of this study was to assess gender differences in temporomandibular joint disc position using magnetic resonance imaging and to check for symptoms in patients with temporomandibular disorders. MATERIALS AND METHODS: Eighty-seven consecutive patients (70 females and 17 males) were evaluated. Bilateral magnetic resonance imaging was performed to determine the temporomandibular joint disc positions; these were divided into four diagnostic categories: no disc displacement, right disc displacement, left disc displacement and bilateral disc displacement. The clinical data assessed were pain on muscle and temporomandibular joint palpation. The data were analyzed using the Fisher's exact test, chi-square test or analysis of variance. Significance was set at p ≤ .05. RESULTS: The study population had more females (80.5%) than males (19.5%) and the mean age of females (31 ± 11 years) was lower than the mean age of males (41± 12 years). Bilateral disc displacement was significantly most frequent in females. Clinical examination showed more pain on muscle palpation for female than for male patients. CONCLUSION: Women had a higher frequency of temporomandibular joint disc displacement, as well as a larger number of painful points on muscle palpation than men.
RESUMO OBJETIVO: O objetivo deste estudo foi avaliar as diferenças de gênero na posição do disco da articulação temporomandibular usando ressonância magnética para verificar se há sintomas em pacientes com disfunção temporomandibular. MATERIAIS E MÉTODOS: Foram avaliados oitenta e sete pacientes consecutivos (70 mulheres e 17 homens); foi realizada ressonância magnética bilateral para determinar as posições do disco da articulação temporomandibular; estes foram divididos em quatro categorias diagnósticas: nenhum deslocamento de disco, deslocamento de disco a direita, deslocamento de disco a esquerda e deslocamento de disco bilateral. Os dados clínicos avaliados foram: dor a palpação no músculo e na articulação temporomandibular. Os dados foram analisados utilizando o teste exato de Fisher, teste do qui-quadrado ou análise de variância. Significância foi de p ≤ 0,05. RESULTADOS: A população do estudo tinha mais mulheres (80,5%) que homens (19,5%). O deslocamento blateral de disco foi significativamente mais frequente no sexo feminino. O exame clínico mostrou mais dor à palpação muscular para mulheres do que para homens. CONCLUSÃO: As mulheres apresentaram uma maior frequência de deslocamento de disco da articulação temporomandibular, bem como um maior número de pontos dolorosos à palpação muscular do que os homens.
Assuntos
Humanos , Articulação Temporomandibular/fisiopatologia , Imageamento por Ressonância Magnética , Síndrome da Disfunção da Articulação Temporomandibular , Análise de VariânciaRESUMO
A Disfunção Temporomandibular (DTM) se refere a várias doenças que envolvem os músculos da mastigação e/ou a articulação temporomandibular (ATM). Ao longo da história, o desenvolvimento de técnicas de imagem possibilitou a avaliação das disfunções intra-articulares. A Ressonância Magnética (RM) é considerada o melhor método de avaliação de imagem para diagnosticar doenças da ATM e o exame mais preciso para detectar a posição do disco articular e visualizar estruturas ósseas, como a cabeça da mandíbula e a fossa mandibular, complementando o exame clínico. A associação entre sinais e sintomas de DTM e achados na RM é controversa na literatura e a correlação entre a posição da cabeça da mandíbula dentro da fossa mandibular e a sintomatologia de pacientes diagnosticados com DTM foi pouco elucidada pelos autores. O objetivo do estudo foi analisar os achados imaginológicos da ressonância magnética quanto à posição da cabeça da mandíbula e quanto à posição do disco articular, verificando sua correlação com os sinais clínicos de estalo e de dor à palpação muscular e articular relatados pelo paciente. Foram analisados 163 prontuários contendo ficha clínica e exame de RM de pacientes com DTM. As fichas clínicas forneceram dados referentes a sinais e sintomas dos pacientes, como presença de estalo e de dor à palpação, e o exame de imagem possibilitou a classificação da posição do disco articular (em posição, deslocado com redução e deslocado sem redução) e da cabeça da mandíbula (concêntrica, posterior e anterior). As variáveis clínicas e imaginológicas foram avaliadas por meio de um método de classificação que proporcionou uma análise dos dados sob o ponto de vista holístico, levando em consideração a situação clínica das duas ATMs do mesmo paciente simultanamente.
Os dados obtidos foram analisando usando o teste exato de Fischer. A classificação adotada dificultou a comparação com outros estudos, já que usualmente os autores fazem a somatória das articulações do lado direito e esquerdo, porém é válida por proporcionar uma análise das variáveis clínicas e imaginológicas dentro de um sistema, que é o indivíduo. No estudo, 20,2% dos pacientes eram homens e 79,8% eram mulheres com média de idade de aproximadamente 37 anos. Os pacientes se distribuíram em maior porcentagem quando houve a mesma posição dos discos articulares bilateralmente (65,0%), porém quanto à cabeça da mandíbula, combinações heterogêneas foram observadas em maior quantidade (60,7%). Apenas 19,1% da amostra não possuía estalo e 25,8% apresentavam dor posterior à cápsula articular. Os músculos mais álgicos foram pterigoideo lateral e masseter, já os menos álgicos foram temporal posterior e cervical. A média de dor total muscular e articular (10,56) se mostrou maior do que a média de dor muscular (9,60) nos pacientes. A dor total em pacientes com ausência de dor posterior à cápsula articular foi significativamente menor do que a dor total em pacientes que apresentam dor posterior à cápsula bilateral. Não houve correlação entre a posição do disco articular e da cabeça da mandíbula, nem entre as variáveis clínicas e imaginológicas. A nova metodologia proposta permitiu a observação de que a maioria dos pacientes apresenta discos bilateralmente concordantes quanto à posição e que a presença de artralgia está relacionada à maior quantidade de músculos álgicos à palpação.
Temporomandibular Disorder (TMD) refers to various diseases involving masticatory muscles and/or temporomandibular joint (TMJ). Throughout history, the development of imaging techniques enabled the evaluation of intra-articular disorders. Magnetic resonance imaging (MRI) is considered the best method for evaluating image to diagnose TMJ diseases and most accurate test to detect the position of the articular disc and display bone structures as the condyle and glenoid fossa, complementing the clinical examination. The association between signs and symptoms of TMD and MRI findings in the literature is controversial and the correlation between the position of the condyle within the fossa and symptoms of patients diagnosed with TMD was somewhat elucidated by the authors. The aim of the study was to analyze the findings of magnetic resonance imaging as the position of the condyle (posterior, anterior or concentric) and on the position of the articular disc (in position, displaced with or without reduction), verifying its correlation with clinical signs clicking and pain on palpation of muscle and joint reported by the patient. We analyzed 163 records containing medical records and MRI in patients with TMD. The medical records provided data for signs and symptoms of patients such as presence of clicking and pain on palpation, and imaging examination allowed the classification of the position of the articular disc (in position, displaced with reduction and displaced without reduction) and condyle (concentric, posterior and anterior). The clinical and imaging procedures were evaluated using a grading method that provided an analysis of the data under the holistic point of view, taking into account the clinical condition of the two TMJs of the same patient. Data were analyzed using the Fisher exact test
Assuntos
Articulação Temporomandibular/fisiologia , Dor Facial/diagnóstico , Imageamento por Ressonância Magnética/métodos , Síndrome da Disfunção da Articulação Temporomandibular/diagnósticoRESUMO
PURPOSE: The aim of this study was to evaluate the influence of complete or partial removable dental prostheses (RDPs) on the frequency of Candida albicans isolated from the mouth and the presence of oral candidiasis in human immunodeficiency virus-positive (HIV+) patients correlated with CD4 levels. MATERIALS AND METHODS: One hundred ninety-three HIV+ patients were evaluated; 68 had RDPs and 125 did not. CD4 cell count was obtained after blood sampling and performed on the day of clinical examination. The material was collected from the buccal mucosa for isolation of yeasts with a sterile swab and seeded onto Sabouraud dextrose agar with chloramphenicol. C albicans strains were identified by testing germ tubes and chlamydospore formation and biochemical (zymogram, auxanogram) characteristics. The results were subjected to the Fischer exact test and chi-square tests. RESULTS: C albicans were isolated from 45 (66.17%) patients who had RDPs and 48 (38.4%) who did not (P = .0003). The presence of oral candidiasis was observed in 14 patients (7.25%), and 10 of the 14 (71.43%) were RDP users. The absence of candidiasis occurred in 121 (67.59%) nonusers and 58 (32.40%) users of RDPs (P = .0065). The mean CD4 cell count was lower in patients with oral candidiasis regardless of the use of RDPs. CONCLUSION: The use of RDPs was an important factor in the isolation of C albicans among HIV+ patients, and CD4 level seems to play a role in the presence of oral candidiasis.