RESUMO
OBJECTIVE: We compared early pulmonary (18)fluorodeoxyglucose ((18)FDG) uptake in infants who had very low birth weight with and without exposure to intrauterine inflammation by using positron emission tomography (PET). A secondary goal was to correlate (18)FDG uptake with later death or bronchopulmonary dysplasia. METHODS: Within 72 hours of birth, 22 singleton infants between 25 and 30 weeks of gestation had a thoracic PET scan after intravenous (18)FDG. Influx constants (K(i)) for (18)FDG were determined. Placental histology assessed exposure to intrauterine inflammation. RESULTS: Chorioamnionitis was found in 13 infants. Seven of these infants also had evidence of funisitis. No inflammation was detected in the remaining nine infants. Median (minimum, maximum) thoracic K(I) was 0.008 (0.006, 0.011) mL/min/mL in infants with funisitis, 0.006 (0.002, 0.008) in infants with chorioamnionitis only, and 0.006 (0.001, 0.015) in infants with no evidence of intrauterine inflammation (P=.16). No relation was found between K(i) and later death or bronchopulmonary dysplasia. Cord blood interleukin-6 was elevated in newborns with placental inflammation (P=.014). CONCLUSION: Early thoracic PET scanning for metabolically active inflammatory cells does not differ between infants with and without exposure to intrauterine inflammation. Evidence of early intrapulmonary sequestration of inflammatory cells in some infants without chorioamnionitis points to the complex etiology of postnatal inflammation.
Assuntos
Displasia Broncopulmonar/diagnóstico por imagem , Corioamnionite/complicações , Fluordesoxiglucose F18/metabolismo , Recém-Nascido de muito Baixo Peso , Pulmão/diagnóstico por imagem , Compostos Radiofarmacêuticos/metabolismo , Tomografia Computadorizada de Emissão , Citocinas/sangue , Feminino , Humanos , Recém-Nascido , Masculino , GravidezRESUMO
In order to examine classification criteria or the CIE-10 Chapter "Organic Mental Disorders including the symptomatics" and to verify its usefulness for the clinician, the most important aspects of the different diagnosis are reviewed and applied in 30 patients according to the type 2--A study of the protocol for field trials of the same instrument. The sample is drawn from both: the University Psychiatric Clinic and the Clinical Hospital of the University of Chile. The most frequent disorders are Dementia and Delirium in their different forms. The rating confidence in most cases was very good or good and the easiness/difficulty range was very easy in most cases in their diagnosis according the instrument criteria. Several suggestions as to applicability and usefulness are presented.
Assuntos
Delírio/diagnóstico , Demência/diagnóstico , Escalas de Graduação Psiquiátrica , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Transtornos Psicóticos/classificação , Transtornos Psicóticos/diagnóstico , Fatores SexuaisRESUMO
In order to examine classification criteria or the CIE-10 Chapter [quot ]Organic Mental Disorders including the symptomatics[quot ] and to verify its usefulness for the clinician, the most important aspects of the different diagnosis are reviewed and applied in 30 patients according to the type 2--A study of the protocol for field trials of the same instrument. The sample is drawn from both: the University Psychiatric Clinic and the Clinical Hospital of the University of Chile. The most frequent disorders are Dementia and Delirium in their different forms. The rating confidence in most cases was very good or good and the easiness/difficulty range was very easy in most cases in their diagnosis according the instrument criteria. Several suggestions as to applicability and usefulness are presented.
RESUMO
In order to examine classification criteria or the CIE-10 Chapter [quot ]Organic Mental Disorders including the symptomatics[quot ] and to verify its usefulness for the clinician, the most important aspects of the different diagnosis are reviewed and applied in 30 patients according to the type 2--A study of the protocol for field trials of the same instrument. The sample is drawn from both: the University Psychiatric Clinic and the Clinical Hospital of the University of Chile. The most frequent disorders are Dementia and Delirium in their different forms. The rating confidence in most cases was very good or good and the easiness/difficulty range was very easy in most cases in their diagnosis according the instrument criteria. Several suggestions as to applicability and usefulness are presented.