RESUMO
The aim of the present study was to compare the acute effects of resistance exercise (RE) designed for hypertrophy or local muscle endurance (LME) on CD4+ and CD8+ T cell apoptosis and migration. 14 untrained subjects (age 20.5±0.8 years, body mass 70.0±12.8 kg, body mass index 24.0±3.2 kg/m(2)), women (N=11) and men (N=3) completed 2 RE sessions (3 sets of 9 exercises) designed for hypertrophy at 10 repetitions maximum (RM) and LME at 60% of 10RM with 1-min rest-intervals between sets and exercises. The investigated lymphocytes were: CD4+, CD4+/CD69RA+, CD8+ and CD8+/CD69RA+ with cell surface markers annexin V and CX3CR1 analyzed by flow cytometry. Percentage of CD4+ positive for annexin V+ were higher immediately following and 24 h after the hypertrophy protocol as compared with LME, while CD4+ positive for CX3CR1 were higher immediately after and lower at the 24 h time point after LME as compared with the hypertrophy session. CD8+ lymphocytes responded similarly to the hypertrophy and LME protocols with elevations in both cellular migration and cell death immediately following and 24 h after the bouts (p≤0.05). Considering that the acute response of CD4+ lymphocytes to RE is protocol-dependent, a gradual adaptation to a hypertrophy program could minimize the effect on CD4+ lymphocytes and reduce the potential susceptibility to antigens during this timeframe. This would also be interesting for a RE program designed for LME based on the observed CD8+ lymphocyte response.
Assuntos
Apoptose/fisiologia , Linfócitos T CD4-Positivos/citologia , Linfócitos T CD8-Positivos/citologia , Movimento Celular , Treinamento Resistido/métodos , Adulto , Contagem de Linfócito CD4 , Feminino , Humanos , Contagem de Linfócitos , Masculino , Músculo Esquelético/fisiologia , Resistência Física/fisiologia , Adulto JovemRESUMO
This investigation was designed to evaluate responses of blood pressure (BP) following an acute resistance exercise (RE) session. Middle-aged women (N=13) who were classified as overweight (N=8) or obese (N=5) according to body mass index (BMI) participated in the investigation. Participants were randomly submitted to a control session (30-min seated rest) and a exercise session (3 sets, 10 repetitions at 60% 1RM of exercises for the upper and lower body) with systolic (SBP), diastolic (DBP) and mean blood pressure (MBP) obtained at rest and 10, 20, 30, 40, 50, and 60-min following exercise, and through 24 h. Acute RE decreased SBP at 10, 30, and 40-min compared with pre-exercise and control (P<0.05). DBP decreased at 10 and 40-min post-exercise compared with the control trial (P<0.05). Both SBP and DBP decreased in the nighttime period (-4.2 mmHg and -4.1 mmHg, respectively) and in the overall 24 h period (-3.6 mmHg and -4.5 mmHg, respectively) following the acute RE session when compared with the control trial. These findings indicate important benefits of acute RE on BP circadian rhythm, particularly at night as well as in the morning, which are critical periods associated with increased risk for cardiovascular events.
Assuntos
Pressão Sanguínea/fisiologia , Sobrepeso/terapia , Treinamento Resistido , Adulto , Análise de Variância , Monitorização Ambulatorial da Pressão Arterial , Ritmo Circadiano , Feminino , Humanos , Pessoa de Meia-Idade , Obesidade/fisiopatologia , Obesidade/terapia , Sobrepeso/fisiopatologia , Resultado do TratamentoRESUMO
The purpose of the present study was to examine the acute effects of resistance training (RT) on CD4⺠and CD8⺠T lymphocytes apoptosis (annexin Vâº) and migration (CX3CR1). Twelve subjects performed two RT sessions (3 sets of 9 exercises) with 1 min (Hyper-1) and 3 min (Hyper-3) of rest-interval length between sets and exercises. CD4⺠and CD8⺠cells count displayed no change following Hyper-1 and Hyper-3. There was an increase in the percentage of CD4⺠positive for annexin V⺠and CX3CR1⺠immediately after and 24 h post Hyper-1. Percentage of CD4⺠positive for annexin V⺠increased 2 and 24 h post Hyper-3, and decreased after CXCR1⺠for the same time-points. There was an increase in CD8⺠positive for annexin V⺠and CX3CR1⺠immediately after, 2 and 24 h post Hyper-1 and Hyper-3, while no differences were found between Hyper-1 and Hyper-3. Acute RT increase the apoptosis and migration of CD4⺠and CD8⺠lymphocytes even 24h after exercise, with minimal effects of rest-interval length.