RESUMO
Introdução: o bem-estar subjetivo se refere a como as pessoas se sentem e avaliam suas vidas. Largamente insinua-se que uma pessoa com altas taxas de bem-estar subjetivo encontra-se satisfeita com a vida e possui altas taxas de afetos positivos e relativa falta de afetos negativos. Objetivo: estimar a prevalência do bem-estar subjetivo de mulheres participantes de um programa social, bem como seus fatores associados. Métodos: estudo epidemiológico, transversal e analítico, no qual a amostra contou com 321 mulheres participantes de um programa social, com idades diversas, do Polo 1 (entre os 29 estudados). As características sociodemográficas e aquelas relacionadas à saúde foram consideradas variáveis independentes, assim como o bem-estar subjetivo foi a dependente. As variáveis foram avaliadas por frequências absolutas e relativas, e a magnitude da associação entre elas foi avaliada pela Razão de Prevalência bruta e ajustada, estimada mediante o modelo de Poisson com variância robusta. Resultados: a maioria das mulheres analisadas era casada (52,4%) e com obesidade (70,3%) e bem-estar subjetivo acima da média (62,8%). As mulheres com 40 anos ou mais apresentaram maior probabilidade de deter melhores índices de bem-estar subjetivo (RP=1,32), enquanto mulheres obesas apresentaram menor probabilidade de apresentar índices satisfatórios de bem-estar subjetivo (RP=0,77). Conclusão: mulheres com idade mais elevada apresentaram maior probabilidade de melhores índices de bem-estar subjetivo, enquanto obesas apresentaram menor probabilidade de índices satisfatórios de bem-estar subjetivo.(AU)
Introduction: Subjective well-being refers to how people feel and value their lives. Very broadly it is implied that a person with high rates of subjective well-being is satisfied with life and has high rates of positive affects and relative lack of negative affects. Objective: to estimate the prevalence of the subjective well-being of practicing individuals of a physical activity program, as well as its associated factors. Methods: an epidemiological, cross-sectional and analytical study, whose sample had 321 women participating in a social program, of different ages, from Polo 1 (among the 29 studied). Sociodemographic and health-related characteristics were considered independent variables, just as subjective well-being was dependent. The variables were evaluated by absolute and relative frequencies and the magnitude of the association between them was evaluated by the gross and Adjusted Prevalence Ratio, estimated using the Poisson model with robust variance. Results: the majority of the women analyzed were married (52.4%) and obese (70.3%) and subjective well-being above average (62.8%). Women who were 40 years of age or older were more likely to have better subjective well-being (PR=1.32), whereas obese women were less likely to present satisfactory subjective well-being (PR=0.77). Conclusion: women with higher age were more likely to have better subjective well-being, while obese women were less likely to have satisfactory subjective well-being rates.(AU)
Assuntos
Indicadores de Qualidade de Vida , Planejamento em Saúde , Exercício FísicoRESUMO
Angiotensin-(1-7) has been described as a new potential therapeutic tool for the treatment and prevention of metabolic disorders by regulating several pathways in visceral white adipose tissue (vWAT). The aim of this study was to access the proteins differentially regulated by Ang-(1-7) using proteomic analysis of visceral adipose tissue. Male mice were divided into three groups and fed for 60 days, with each group receiving one of the following diets: standard diet+HPßCD (ST), high fat diet+HPßCD (HFD) and high fat diet+Ang-(1-7)/HPßCD (HFD+Ang-(1-7)). Body weight, fat weight and food intake were measured. At the end of treatment, Ang-(1-7) induced a decrease in body and fat weight. Differential proteomic analysis using two-dimensional electrophoresis (2-DE) combined with mass spectrometry were performed. Results of protein mapping of mesenteric adipose tissue using 2-DE revealed the presence of about 450 spots in each gel (n=3/treatment) with great reproducibility (>70%). Image analysis and further statistical analysis allowed the detection and identification of eight proteins whose expression was modulated in response to HFD when compared to ST. Among these, two proteins showed a sensitive response to Ang-(1-7) treatment (eno1 and aldehyde dehydrogenase). In addition, three proteins were expressed statistically different between HFD+Ang-(1-7) and HFD groups, and four proteins were modulated compared to standard diet. In conclusion, comparative proteomic analysis of a mice model of diet-induced obesity allowed us to outline possible pathways involved in the response to Ang-(1-7), suggesting that Ang-(1-7) may be a useful tool for the treatment of metabolic disorders.