RESUMO
B-type natriuretic peptide (BNP) is widely used in the treatment of early-stage heart failure and coronary heart disease. In this study, the association of plasma BNP concentration with myocardial infarct (MI) size in patients with acute myocardial infarction (AMI) was investigated. Eighty patients with AMI were enrolled in the MI group and 30 healthy volunteers were selected as the control group. Magnetic resonance imaging of the heart and plasma BNP concentration detection were carried out, and then the relationship between plasma BNP concentration and MI size was analyzed in the two groups. Results showed that the plasma BNP concentration was positively related to MI size (r = 0.645, P < 0.0005), whereas it was negatively correlated to the left ventriculus ejection fraction (r = 0.297, P = 0.047). Multiple regression analysis showed that MI size was the only parameter that was independently associated with BNP (r(2) = 0.32, F = 7.712, P = 0.007). Moreover, when the BNP level reached 150 pg/mL, it had 85.1% sensitivity and 70.4% specificity of determining MI sizes exceeding 10%. The plasma concentration of BNP is highly related to MI size in patients with AMI, and can be clinically used to evaluate MI size.
Assuntos
Infarto do Miocárdio/sangue , Infarto do Miocárdio/patologia , Peptídeo Natriurético Encefálico/sangue , Idoso , Estudos de Casos e Controles , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/diagnóstico , Infarto do Miocárdio/fisiopatologia , Curva ROC , Fatores de Risco , Volume Sistólico , Função Ventricular EsquerdaRESUMO
Genetic diversity of Stipa breviflora populations in the Inner Mongolian grasslands of China and its possible correlation with climatic factors was examined using geographic information systems and random amplified polymorphism DNA analysis. A total of 308 bands were produced with 28 arbitrary decamer oligonucleotide. Three major findings were demonstrated. First, the genetic diversity of S. breviflora was high but lower than that of Stipa grandis and Stipa krylovii. Second, genetic distances between the populations analyzed using the unweighted pair group method and the Mantel test had a highly positive correlation with geographical distances, indicating that spatial separation of this species in the studied area produced genetic shift in the population. Finally, both canonical correspondence and Pearson's analyses revealed strong correlations between genetic differentiation and temperature in the area. We therefore conclude that temperature variations play an important role in genetic differentiations among the investigated S. breviflora populations.