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The establishment of anthropometric measurements is of fundamental importance for the correct identification of human bodies. The objective of this study was to evaluate the accuracy and reliability of two-dimensional craniometric landmarks obtained from three-dimensional cone beam computed tomography reconstructions for forensic identification of humans. Computed tomography images with voxel sizes of 0.25, 0.3, and 0.4 mm were obtained using i-CAT® three-dimensional equipment. Ten landmarks were randomly selected, and 10 measurements were demarcated in the three-dimensional reconstruction to evaluate the mandibular condyle, ramus, and body. This study demonstrated that protocols with voxels of 0.3 mm should be preferentially indicated for the evaluation of linear and angular measurements. Implementing our methodology using prototypes for clinical and forensic simulations allows comparisons with human databases in identification issues.

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The quinolinic ring, present in several molecules, possesses a great diversity of biological activities. Therefore, this ring is in the structural composition of several candidates of drugs in preclinical and clinical studies; thus, it is necessary to compile these results to facilitate the design of new drugs. For this reason, some of the activities of compounds are selected to examine in this review, such as antimalarial, antimicrobial, anticancer, anti-inflammatory, antidiabetic, anti-rheumatic, and antiviral activities. All publications of scientific articles chosen are dated between 2000 and 2020. In addition to presenting the structures of some natural and synthetic compounds with their activities, we have listed the clinical studies of phases III and IV on antimalarial drugs containing the quinoline nucleus and phase III clinical studies on hydroxychloroquine and chloroquine to assess their possible role in COVID-19. Finally, we have reviewed some of the mechanisms of action, as well as the side effects of some of the quinolinic derivatives.

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Objective To describe a new presentation of tears and retears of the rotator cuff, which we denominate captured rotator cuff (CRC). We also aim to evaluate it clinically and through images. Methods We assessed retrospectively 16 patients with intraoperative diagnosis of CRC between March 2005 and September 2017; by means of imaging (radiography and magnetic resonance imaging [MRI]) and functional scores (UCLA and Constant & Murley). In images we analyzed the evolution for rotator cuff arthropathy and presence of retears. Functionally, we compared the affected side with the contralateral side and extensive lesions with nonextensive. Results Five (31.25%) patients presented with rotator cuff arthropathy, and 10 (62.5%) with retears. Three (75%) patients with nonextensive lesions had good/excellent UCLA and Constant & Murley scores. In patients with extensive lesions, when the Constant & Murley score was evaluated, 6 (50%) presented good/excellent results, and in the UCLA score, 7 (58.3%). Comparing the affected side (Constant 74.72 points; UCLA 20 points) with the contralateral side (Constant 96.96 points; UCLA 25.63 points), there were worse functional results with statistical significance. Conclusion The diagnosis of CRC is suspected by characteristic findings on MRI and confirmed in arthroscopy. The affected shoulders present worse functional postoperative scores.

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Abstract Objective To describe a new presentation of tears and retears of the rotator cuff, which we denominate captured rotator cuff (CRC). We also aim to evaluate it clinically and through images. Methods We assessed retrospectively 16 patients with intraoperative diagnosis of CRC between March 2005 and September 2017; by means of imaging (radiography and magnetic resonance imaging [MRI]) and functional scores (UCLA and Constant & Murley). In images we analyzed the evolution for rotator cuff arthropathy and presence of retears. Functionally, we compared the affected side with the contralateral side and extensive lesions with nonextensive. Results Five (31.25%) patients presented with rotator cuff arthropathy, and 10 (62.5%) with retears. Three (75%) patients with nonextensive lesions had good/excellent UCLA and Constant & Murley scores. In patients with extensive lesions, when the Constant & Murley score was evaluated, 6 (50%) presented good/excellent results, and in the UCLA score, 7 (58.3%). Comparing the affected side (Constant 74.72 points; UCLA 20 points) with the contralateral side (Constant 96.96 points; UCLA 25.63 points), there were worse functional results with statistical significance. Conclusion The diagnosis of CRC is suspected by characteristic findings on MRI and confirmed in arthroscopy. The affected shoulders present worse functional postoperative scores.

Resumo Objetivo Descrever uma nova apresentação de ruptura e rerruptura do manguito rotador (MR), a qual denominamos manguito capturado (MC). Objetivamos também avaliá-la clinicamente e por meio de imagens. Métodos Foram avaliados retrospectivamente 16 pacientes com diagnóstico intraoperatório de MC no período de março de 2005 a setembro de 2017; por meio de exames de imagem (radiografia e ressonância magnética [RM]) e escores funcionais (UCLA e Constant & Murley). Nas imagens, analisamos a evolução para artropatia do manguito rotador e presença de rerrupturas. Funcionalmente, comparamos o lado afetado com o contralateral e as lesões extensas com nãoextensas. Resultados Cinco (31,25%) pacientes evoluíram com artropatia do manguito rotador e 10 (62,5%) tiveram rerrupturas. Três (75%) pacientes com lesões não extensas tiveram UCLA e Constant & Murley bons/excelentes. Nos pacientes com lesões extensas, quando avaliado Constant & Murley, 6 (50%) apresentaram resultados bons/excelentes, e no escore UCLA, 7 (58,3%). Comparando o lado acometido (Constant 74,72 pontos; UCLA 20 pontos) com o contralateral (Constant 96,96 pontos; UCLA 25,63 pontos), houve pior resultado funcional com significância estatística. Conclusão O diagnóstico de MC é suspeitado por achados característicos na RM e confirmado na artroscopia. Os ombros acometidos apresentam piores escores funcionais pós-operatórios.

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BACKGROUND: The etiology of inflammatory bowel disease (IBD) is unknown, but it is believed to be multifactorial. The hygiene hypothesis proposes that better hygiene conditions would lead to less infectious disease during childhood and favor the development of immune-mediated diseases. AIM: To test the hygiene hypothesis in IBD by assessing the environmental risk factors associated with IBD development in different regions of Brazil with diverse socioeconomic development indices. METHODS: A multicenter case-control study was carried out with 548 Crohn's disease (CD) and 492 ulcerative colitis (UC) outpatients and 416 healthy controls, from six IBD centers within different Brazilian states at diverse socioeconomic development stages. A semi-structured questionnaire with 87 socioeconomic and environmental questions was applied. Logistic regression model was created to assess the odds ratio (OR) with P value and 95% confidence intervals (CI). RESULTS: Predictive variables for both diseases (CD and UC) were women [odd ratios (OR) = 1.31; OR = 1.69], low monthly family income (OR = 1.78; OR = 1.57), lower number of cohabitants (OR = 1.70; OR = 1.60), absence of vaccination (OR = 3.11; OR = 2.51), previous history of bowel infections (OR = 1.78; OR = 1.49), and family history of IBD (OR = 5.26; OR = 3.33). Associated risk factors for CD were age (18-39 years) (OR = 1.73), higher educational level (OR = 2.22), absence of infectious childhood diseases (OR = 1.99). The UC predictive variables were living in an urban area (OR = 1.62), inadequate living conditions (OR = 1.48) and former smokers (OR = 3.36). Appendectomy was a risk factor for CD (OR = 1.58) with inverse association with UC (OR = 4.79). Consumption of treated and untreated water was associated with risk of CD (OR = 1.38) and UC (OR = 1.53), respectively. CONCLUSION: This is the first examining environmental exposures as risk factors for inflammatory bowel disease in Brazil. Most of the variables associated with disease risk support the role of the hygiene hypothesis in IBD development.

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RESUMO: Este trabalho pretende demonstrar que, em Freud, a interpretação se configura como um ato criador de realidades. Em nosso percurso, partimos do exame das políticas da representação no mundo antigo para, em seguida, apontarmos as divergências entre o estatuto da interpretação em Freud e em Artemidoro. Ao final, nos interessa destacar que a interpretação analítica não descortina, mas funda, retroativamente, o passado.

Abstract: This paper intends to demonstrate that, on the psychoanalytic field, the interpretation is itself an act of creation. Starting from the analysis of the Ancient World's representation politiques, latter on we highlight some of the differences between the use of the interpretation in Freud and in Artemidorus. As we demonstrate in the end of this paper, the psychoanalytic interpretation doesn't reveal the past but establishes it retroactively.

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O objetivo deste artigo é verificar se, e, em que medida o processo autogestionário em quatro Organizações de Trabalho Associado (OTAs) pode impulsionar transformações cotidianas das relações de trabalho, e se este processo está relacionado a outras perspectivas mais amplas de resistência política. Tal abordagem, influenciada pela pesquisa-ação e pela enquete operária de Karl Marx, interpreta o impacto da relação (autogestão x processo de consciência) e os seus condicionantes, para problematizar os avanços e desafios da autogestão como mediação para aprimorar o processo de consciência e autodeterminação dos/as trabalhadores/as, ou seja: as rupturas e as continuidades do Trabalho Associado com a antiga forma (heterogestionária) merecem e precisam ser apuradas. O cruzamento e a interpretação dos indicadores institucionais e comportamentais utilizados na pesquisa concluem a existência de 3 tipologias de consciência dominantes nas Organizações de Trabalho Associado em processo de autogestão.(AU)

The aim of this research is to verify if and to what extent the self-management process in four Associated Work Organizations drives daily transformations of labor relations and is related to other broader perspectives of political struggle. Such an approach, influenced by action research and worker poll, interprets the impact of the relationship (self-management x consciousness) and its constraints, to problematize the limits and possibilities of selfmanagement as mediation to improve the process of self-determination and self-determination workers, that is: the ruptures and continuities of Work Associated with the old form deserve and need to be unveiled. The intersection and interpretation of the institutional and behavioral indicators used in the research conclude the existence of 3 dominant typologies of consciousness in Associate Work Organizations in self-management process.

El patrón de sociabilidad forjado por el capital no puede ser superado por decreto, como en un pase de hechizos, o por la simple socialización de los medios de producción. El objetivo de esta investigación es verificar si, y en qué medida, el proceso autogestionario en cuatro Organizaciones de Trabajo Asociado impulsa transformaciones cotidianas de las relaciones de trabajo, y se relaciona con otras perspectivas más amplias de lucha política. Este enfoque, influenciado por la investigación-acción y la encuesta obrera, interpreta el impacto de la relación (autogestión x conciencia) y sus condicionantes, para problematizar los límites y las posibilidades de la autogestión como mediación para perfeccionar el proceso de conciencia y autodeterminación de los / as, los trabajadores / as, es decir: las rupturas y las continuidades del Trabajo Asociado con la antigua forma merecen y necesitan ser desveladas. La intersección e interpretación de los indicadores institucionales y de comportamiento utilizados en la investigación concluyen la existencia de 3 tipologías dominantes de conciencia en las Organizaciones de Trabajo Asociadas en el proceso de autogestión.(AU)

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Objetivo: Avaliar a influência do excesso de peso nos valores de pressão arterial (PA) de escolares 4 a 17 anos em uma cidade no interior de Sergipe. Metodologia: Trata-se de um estudo transversal, em que foram avaliados 119 estudantes de 5 escolas, por meio de avaliação antropométrica e obtenção dos valores da PA. Os estudantes foram classificados quanto seu estado nutricional e a presença de níveis pressóricos alte-rados de acordo com os percentis propostos pela Organização Mundial da Saúde e da Sociedade Brasileira de Cardiologia, respectivamente. Em seguida, os dados foram analisados estatisticamente com o programa GraphPad Prism V7.0., utilizando-se o teste de Mann Whitney para comparação e o coeficiente de Spearman para correlação entre duas variáveis, sendo adotado como nível de significância, 5%. Resultados:Dos 119 estudantes avaliados, 8,41% foram considerados com baixo peso, 38,32% eutróficos e 53,27% com excesso de peso. Os estudantes com excesso de peso apresentaram maiores medidas de circunferência abdominal. Observou-se uma correlação forte e positiva entre os valores de IMC-z e a razão CA/A, em que os estudantes com maiores valores de IMC-z possuíam também valores maiores da relação CA/A. Além disso, foi constatado maior número de estudantes com níveis considerados PA alterados, dentre aqueles que pos-suíam maiores medidas tanto de IMC-z e quanto da relação CA/A. Conclusão: Crianças e adolescentes com PA alterada apresentaram maior média de IMC e maior relação CA/A em comparação com as que possuíam PA normal, o que evidencia a necessidade de intervenção nessa população para prevenção e promoção da saúde.(AU)

Objective: To evaluate the influence of overweight on blood pressure (BP) values of schoolers aged 4 to 17 years in a city in the Sergipe countryside. Methodology: This is a cross-sectional study, in which 119 students from 5 schools were evaluated through anthropometric evaluation and BP values. The students were classified as their nutritional status and the presence of BP levels altered according to the percentiles proposed by the World Health Organization and the Brazilian Society of Cardi-ology, respectively. Data were then analyzed statistically in the GraphPad Prism V7.0 program, using the Mann Whitney test for comparison and the Spearman coefficient for correlation between two variables, being adopted as a significance level of 5%. Results: Of the 119 students evaluated, 8.41% were con-sidered underweight, 38.32% were eutrophic and 53.27% were overweight. Overweight students presented greater measures of Abdominal Circumference. A strong and positive correlation was also observed between the values of BMI-z and the CA/A ratio, where students with higher BMI-z values also had higher values of the CA/A ratio. In addition, a greater number of stu-dents with altered BP levels were observed among those who had greater measures of both BMI-z and CA/A ratio. Conclusion:Children and adolescents with altered BP had a higher mean BMI and higher CA/A ratio compared to those with normal BP, which reveals the need for intervention in this population for prevention and health promotion. (AU)

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Introdução:O contato extracurricular com a pesquisa científica pode ajudar a melhorar as habilidades dos alunos e são muitos os potenciais influenciadores na adesão dos estudantes. Objetivo: Identificar níveis de conhecimento científico e atitudes científicas de estudantes de medicina bem como as principais barreiras para a prática científica. Casuística e Métodos: Estudo transversal realizado com acadêmicos de medicina do Campus Prof. Antônio Garcia Filho da Universidade Federal de Sergipe, Brasil. Aplicaram-se questionários validados a 90 estudantes que em seguida, foram agrupados em quatro classificações (não envolvidos em projetos; envolvidos em extensão; envolvidos em pesquisa e envolvidos em ambos (pesquisa e extensão). Resultados:Parcela significativa dos estudantes envolveu-se com projetos de pesquisa e extensão (43,33%) e as médias gerais de atitude e conhecimento científicos foram moderadas (56,85 ± 14,35; 47,28 ± 16,69). Os grupos de estudantes que participaram de pesquisa junto com extensão, apresentaram maiores pontuações de atitude científica (63,10 ± 13,69) e o conhecimento científico de todos os grupos foi similar. As barreiras, para a prática científica, mais citadas foram a falta de estrutura (73,33%), de tempo (70%), de orientação (67,78%), o foco nas atividades curriculares (54,44%) e falta de familiaridade com estatística (50%). Conclusão: Estudantes que apresentavam contato com pesquisa cientifica e extensão apresentaram atitudes mais positivas para pesquisa, demonstrando a importância do estímulo a essa prática. As barreiras, para as práticas científicas, mostraram-se similares à literatura mundial, mostrando que devem ser feitas medidas para reduzi-las e estimular a prática científica.

Introduction: Extracurricular contact with scientific research can help to improve students' skills and there are many potential influencers of students'adhesion. Objectives: Identify levels of scientific knowledge and attitudes towards scientific research among medical students, as well as the main barriers to scientific practice. C asuistic and methods:This is a cross-sectional study involving medical students from the Federal University of Sergipe, Brazil, Campus Prof. Antônio Garcia Filho. Validated questionnaires were applied to 90 students. Then, they were grouped in four classifications (not involved in projects; involved in non-degree projects; involved in research projects, and involved in both non-degree and research projects). Results: Significant parcel of students was involved on research and non-degree projects (43.33%). The overall averages of scientific knowledge and attitudes were moderate (56.85 ±14.35; 47.28 ±16.69). Groups of students involved in scientific research and community outreach, presented higher scores of scientific attitudes (63.10 ± 13.69). The scientific knowledge of all groups was similar. The most cited barriers for scientific practice were lacked of structure (73.33%), lack of time (70%), lack of orientation (67.78%), the focus on curricular activities (54.44%), and the lack of familiarity with statistics (50%). Conclusion: Students who had contact with scientific research and community outreach had more positive attitudes towards research, showing the importance of stimuli to this practice. The barriers for scientific practice were similar to world's data, showing that measures have to be taken to reduce them and stimulate the scientific research.

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Justicia pectoralis Jacq. (Acanthaceae) leaves currently found in the Brazilian north-east are widely used to treat diabetes, menstrual pains, asthma, and other disorders. This work aimed to identify the phytochemical characterization and biological activities of J. pectoralis leaf extracts. The plant material was ground and the crude extracts were obtained with water or acetone: water (7:3 v/v), yielding aqueous (JPA), and organic (JPO) extracts. Phytochemical characterization was performed by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). Cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay and trypan blue (TB) exclusion assay in peripheral blood mononuclear cells (PBMCs), BALB/c splenocytes, and neoplastic cells (TOLEDO, K562, DU-145, and PANC-1) at 1, 10, and 100 µg/mL. Antibacterial activity was evaluated using the microdilution test to obtain the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Cytokines, IFN-γ, and IL-17A from culture supernatants of BALB/c mice splenocytes were measured by sandwich ELISA. In the TLC analysis, both JPA and JPO extracts presented coumarin and flavonoids. In addition, HPLC was able to identify coumarin, apigenin, and ellagic acid in both extracts. JPO IC50 was 57.59 ± 1.03 µg/mL (MTT) and 69.44 ± 8.08 µg/mL (TB) in TOLEDO. MIC value of JPO against Acinetobacter baumannii and Klebsiella pneumoniae was 500 µg/mL. JPO (100 µg/mL) significantly inhibited IFN-γ levels (p=0.03). J. pectoralis is a potential candidate to be further investigated as an IFN-γ inhibitory agent and against Acinetobacter baumannii and Klebsiella pneumoniae.