RESUMO
Dementias are responsible for the most frequent neurodegenerative diseases and the seventh leading cause of death worldwide. As a result, there is a growing effort by the neuroscientific community to understand the physiopathology of neurodegenerative diseases, including how to alleviate the effects of the cognitive decline by means of non-pharmacological therapies (e.g., physical exercise). Studies have shown that exercise can improve aspects of brain health related to cognition. However, there still needs to be more knowledge regarding the mechanisms controlling these relationships, and a newly discovered cleansing system in the brain, named the glymphatic system, can be the missing link in this mechanism. The objective of this paper is to review recent findings regarding the potential impacts of physical exercise on the glymphatic system and its implications for the onset of neurodegenerative diseases. Additionally, considering the close interplay between exercise and sleep quality, we aim to explore how sleep patterns may intersect with exercise-induced effects on glymphatic function, further elucidating the complex relationship between lifestyle factors and brain health.
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Objective: To evaluate the impact of a multicomponent physical exercise program on clinical variables associated with the glymphatic clearance system, sleep-awake patterns, and cognitive function in individuals with mild cognitive impairment or mild Alzheimer's disease. Methods: This is a single-center parallel randomized controlled trial involving pre- and post-intervention assessments. The intervention consists of a 12 (±3)-week multicomponent aerobic and resistance physical exercise program of moderate intensity divided into 2 groups: an experimental group (undergoing multicomponent training) and a control group (no intervention). Eligible participants are those diagnosed with probable mild cognitive impairment or mild Alzheimer's disease. Expected results: Anticipated outcomes suggest that the multicomponent training protocol, incorporating both aerobic and resistance physical exercises at a moderate intensity, will yield improvements in glymphatic clearance dynamics, sleep-awake parameters, and performance on cognitive, functional, and behavioral tasks among eligible patients. Relevance: The need to move beyond cognitive clinical testing justifies our trial, which proposes an assessment employing neuroimaging techniques and the analysis of biomarkers present in cerebrospinal fluid in conjunction with clinical tests for physical and cognitive assessment. (AU)
Assuntos
Humanos , Idoso , Idoso de 80 Anos ou mais , Exercício Físico , Doença de Alzheimer , Sistema GlinfáticoRESUMO
OBJECTIVE: Systematically review randomized controlled trials on the efficacy of cognitive training on executive functions in healthy older people. MEASURES: The outcome measures were related to inhibitory control, working memory, and cognitive flexibility. RESULTS: Thirty-one trials were included in the systematic review and thirteen trials in the meta-analysis. In the overall analysis, the cognitive training enhanced inhibitory control when measured by the Stroop task (p < .001, d = 1.64) and working memory when measured by the Corsi Block task (p = .002, d = .16). A marginal significance was found for working memory in the Digit Span task - Forward (p = .06, d = .92). However, cognitive training did not enhance inhibitory control when measured by the Go/No-Go task (p = .76, d = .59), working memory when measured by the Digit Span - Backward (p = .72, d = .95) and N-Back (p = .10, d = .26) tasks, and cognitive flexibility when measured by Trail Making - Part B (p = .08, d = .27) and Semantic Fluency (p = .49, d = .06) tasks. CONCLUSION: Mixed evidence was found for inhibitory control and working memory; cognitive flexibility showed no evidence of improvement.
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As quedas em pessoas com Doença de Parkinson (DP) são fatores limitantes e incapacitantes, sua compreensão é complexa dada a natureza multifatorial. Neste contexto uma ferramenta, o diário de quedas, pode ser alternativa significante na compreensão deste evento. Objetivo: Avaliar a utilização do diário de quedas como ferramenta de monitoramento das quedas em pessoas com DP. Métodos: Trata-se de uma revisão sistemática de literatura que teve a seguinte questão norteadora: o diário de quedas é uma ferramenta adequada para monitorar as quedas em pessoas com DP? A busca nas bases de dados Pubmed, Medline, PEDro, Web of Science, Scopus e Cochrane Library foi realizada entre os meses de janeiro a março de 2022. A revisão foi registrada na plataforma PROSPERO sob o número de registro: CRD42018099127. Resultados: 192 estudos foram recuperados nas bases de dados, após adoção dos critérios de inclusão e exclusão, 6 estudos foram incluídos nesta revisão, a variável diário de quedas foi descrita sumariamente nos estudos analisados e extraído informações do que deveria conter em um diário de quedas. Conclusão: A análise permitiu concluir que os diários de quedas são ferramentas importantes para registro e compreensão do evento queda em pessoas com DP, no entanto, carecem de padronização
Falls in people with Parkinson's disease (PD) are limiting and disabling factors, their understanding is complex given their multifactorial nature. In this context, a tool, the fall diary, can be a significant alternative in understanding this event. Objective: Evaluate the use of the fall diary as a tool to monitor falls in people with PD. Methods: This is a systematic literature review that had the following guiding question: is the fall diary an adequate tool to monitor falls in people with PD? The search in Pubmed, Medline, PEDro, Web of Science, Scopus and Cochrane Library databases was carried out between January and March 2022. The review was registered on the PROSPERO platform under registration number: CRD42018099127. Results: A total of 192 studies were retrieved from the databases, after adopting the inclusion and exclusion criteria, 6 studies were included in this review, the daily variable of falls was briefly described in the analyzed studies and information was extracted from what it should contain in a falls diary. Conclusion: The analysis allowed us to conclude that fall diaries are important tools for recording and understanding the fall event in people with PD, however, they lack standardization
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O objetivo deste trabalho foi mensurar o grau de cifose torácica em mulheres idosas, por meio do Método Flexicurva, correlacionando este achado com o de Densitometria Óssea (DMX), hábitos de vida e características antropométricas. Foram selecionadas 100 mulheres que haviam realizado o exame de DMX e divididas em 3 grupos de acordo com o nível de densidade mineral óssea (DMO): normal, osteogênicas e osteoporóticas. Realizou-se avaliação do grau de cifose torácica com o método Flexicurva. As variáveis: grau de cifose; DMO; idade; dados antropométricos foram comparadas entre os grupos e comparadas com os hábitos de vida. O grupo com osteoporose mostrou diferenças significativas quanto à idade, peso e IMC. Não foi observada diferença significativa nas variáveis relacionadas aos hábitos de vida. As participantes com osteoporose apresentaram maior grau de cifose torácica na postura habitual, porém sem diferença significativa entre os grupos. Também não houve correlação entre as variáveis analisadas. O envelhecimento, a diminuição do peso corporal e do IMC estão ligados ao processo de osteoporose. Flexicurva não foi capaz de diferenciar as idosas quanto ao nível de DMO.
The objective of this study was to mesure the kyphosis thoracic degree in older women through Flexicurve method, correlating this finding with Bone Densitometry, habits of life and anthropometric characteristics. 100 women who had undergone the examination of DMX were selected and divided into 3 groups according to the level of bone mineral density (BMD): the normal, osteopenic and osteoporotic. Was carried out assessing the degree of thoracic kyphosis with Flexicurve method. Variables: degree of kyphosis; BMD; age; and anthropometric data were compared between groups and compared with the habits of life. The group with osteoporosis showed significant differences in age, weight and BMI. No significant difference was observed related to lifestyle variables. The participants with osteoporosis showed higher degree of thoracic kyphosis in normal stance, but with no significant difference between groups. There was also no correlation between the variables. Aging, decreasing body weight and BMI are connected to the osteoporosis process. Flexicurve was not able to differentiate the older in the level of BMD.
El objetivo de este trabajo fue medir el grado de cifosis torácica en mujeres mayores, por medio del Método Flexicurva, correlacionando este hallazgo con el de Densitometría Ósea (DMX), hábitos de vida y características antropométricas. Se seleccionaron 100 mujeres que habían realizado el examen de DMX y se dividieron en 3 grupos de acuerdo con el nivel de densidad mineral ósea (DMO): normal, osteogénicos y osteoporóticos. Se realizó una evaluación del grado de cifosis torácica con el método Flexicurva. Las variables: grado de cifosis; DMO; edad; y datos antropométricos fueron comparados entre los grupos y comparados con los hábitos de vida. El grupo con osteoporosis mostró diferencias significativas en cuanto a edad, peso e IMC. No se observó diferencia significativa en las variables relacionadas con los hábitos de vida. Las participantes con osteoporosis presentaron mayor grado de cifosis torácica en la postura habitual, pero sin diferencia significativa entre los grupos. También no hubo correlación entre las variables analizadas. El envejecimiento, la disminución del peso corporal y del IMC están vinculados al proceso de osteoporosis. Flexicurva no fue capaz de diferenciar a las personas mayores en cuanto al nivel de DMO.