RESUMO
The use of saline water is one of the major challenges of agriculture, as it can cause nutritional imbalances and thus reduce crop yield. This study proposes to examine the efficiency of potassium nutrition asa salt stress-mitigating agent in melon grown in a protected environment. The experiment was laid outin a randomized-block design with ten treatments in a 2 × 4 factorial arrangement represented by two melon cultivars (McLaren and SV1044MF) and four nutrient solutions (S1 - standard nutrient solution, 2.5 dS m-¹; S2 - nutrient solution salinized with NaCl, 5.0 dS m-¹; S3 - nutrient solution salinized with NaCl + 50% K, 6.5 dS m-¹; and S4 - nutrient solution salinized with NaCl + 100% K, 7.5 dS m-¹). Yield (average fruit weight, production, fruit diameter, internal cavity, and pulp thickness), quality (pulp firmness, total sugars, soluble solids [SS], vitamin C, pH, titratable acidity [TA] and SS/TA ratio) and nutritional (K, Na and K/Na ratio) variables were evaluated. Plants fertigated with standard nutrient solution showed the highest values for fruit weight (1,190.6 g), production (2,381.3 g per plant), fruit diameter (13.6 cm) and pulp thickness (2.6 cm) Cultivar McLaren produced heavier fruits (931.4 g) with larger diameter (12.4 cm) and pulp thickness (2.4cm). The addition of NaCl to nutrient solution induced a reduction in the yield variables but did not influence fruit quality. The addition of extra K to salinized nutrient solution did not mitigate the deleterious effect of salinity on the yield of melon.
O uso de água salina é um dos principais desafios na produção agrícola, pois pode provocar desbalanço nutricional e, consequentemente, reduzir o rendimento das culturas. Este trabalho teve como objetivo avaliar a eficiência da nutrição potássica como agente atenuador do estresse salino no meloeiro cultivado em ambiente protegido. O delineamento experimental utilizado foi em blocos casualizados, com dez tratamentos arranjados em esquema fatorial 2 × 4, sendo dois cultivares de meloeiro (McLarene SV1044MF) e quatro soluções nutritivas (S1- solução nutritiva padrão, 2,5 dS m-¹; S2 solução nutritiva salinizada com NaCl, 5,0 dS m-¹; S3 solução nutritiva salinizada com NaCl + 50% K, 6,5 dS m-¹; S4 - solução nutritiva salinizada com NaCl + 100% K, 7,5 dS m-¹). As variáveis de rendimento (peso médio de fruto, produção, diâmetro de fruto, cavidade interna e espessura de polpa), qualidade (firmeza de polpa, açúcares totais, sólidos solúveis, vitamina C, pH, acidez titulável e razão SS/AT) e nutrição (K, Na e razão K/Na) foram avaliadas. Plantas fertirrigadas com solução nutritiva padrão apresentaram maiores valores para peso de frutos (1.190,6 g), produção (2.381,3 g planta-¹), diâmetro de fruto (13,6 cm) e espessura de polpa (2,6 cm). O cv. McLaren apresentou frutos mais pesados (931,4 g), com maior diâmetro (12,4 cm) e espessura de polpa (2,4 cm). A adição de NaCl na solução nutritiva provocou redução nas variáveis de rendimento, mas não influenciou a qualidade dos frutos. A adição extra de K em solução nutritiva salinizada não atenuou o efeito deletério da salinidade sobre o rendimento do meloeiro.
Assuntos
Cucumis melo/química , Estresse Salino , Minerais/análise , Potássio/administração & dosagemRESUMO
The use of saline water is one of the major challenges of agriculture, as it can cause nutritional imbalances and thus reduce crop yield. This study proposes to examine the efficiency of potassium nutrition asa salt stress-mitigating agent in melon grown in a protected environment. The experiment was laid outin a randomized-block design with ten treatments in a 2 × 4 factorial arrangement represented by two melon cultivars (McLaren and SV1044MF) and four nutrient solutions (S1 - standard nutrient solution, 2.5 dS m-¹; S2 - nutrient solution salinized with NaCl, 5.0 dS m-¹; S3 - nutrient solution salinized with NaCl + 50% K, 6.5 dS m-¹; and S4 - nutrient solution salinized with NaCl + 100% K, 7.5 dS m-¹). Yield (average fruit weight, production, fruit diameter, internal cavity, and pulp thickness), quality (pulp firmness, total sugars, soluble solids [SS], vitamin C, pH, titratable acidity [TA] and SS/TA ratio) and nutritional (K, Na and K/Na ratio) variables were evaluated. Plants fertigated with standard nutrient solution showed the highest values for fruit weight (1,190.6 g), production (2,381.3 g per plant), fruit diameter (13.6 cm) and pulp thickness (2.6 cm) Cultivar McLaren produced heavier fruits (931.4 g) with larger diameter (12.4 cm) and pulp thickness (2.4cm). The addition of NaCl to nutrient solution induced a reduction in the yield variables but did not influence fruit quality. The addition of extra K to salinized nutrient solution did not mitigate the deleterious effect of salinity on the yield of melon.(AU)
O uso de água salina é um dos principais desafios na produção agrícola, pois pode provocar desbalanço nutricional e, consequentemente, reduzir o rendimento das culturas. Este trabalho teve como objetivo avaliar a eficiência da nutrição potássica como agente atenuador do estresse salino no meloeiro cultivado em ambiente protegido. O delineamento experimental utilizado foi em blocos casualizados, com dez tratamentos arranjados em esquema fatorial 2 × 4, sendo dois cultivares de meloeiro (McLarene SV1044MF) e quatro soluções nutritivas (S1- solução nutritiva padrão, 2,5 dS m-¹; S2 solução nutritiva salinizada com NaCl, 5,0 dS m-¹; S3 solução nutritiva salinizada com NaCl + 50% K, 6,5 dS m-¹; S4 - solução nutritiva salinizada com NaCl + 100% K, 7,5 dS m-¹). As variáveis de rendimento (peso médio de fruto, produção, diâmetro de fruto, cavidade interna e espessura de polpa), qualidade (firmeza de polpa, açúcares totais, sólidos solúveis, vitamina C, pH, acidez titulável e razão SS/AT) e nutrição (K, Na e razão K/Na) foram avaliadas. Plantas fertirrigadas com solução nutritiva padrão apresentaram maiores valores para peso de frutos (1.190,6 g), produção (2.381,3 g planta-¹), diâmetro de fruto (13,6 cm) e espessura de polpa (2,6 cm). O cv. McLaren apresentou frutos mais pesados (931,4 g), com maior diâmetro (12,4 cm) e espessura de polpa (2,4 cm). A adição de NaCl na solução nutritiva provocou redução nas variáveis de rendimento, mas não influenciou a qualidade dos frutos. A adição extra de K em solução nutritiva salinizada não atenuou o efeito deletério da salinidade sobre o rendimento do meloeiro.(AU)
Assuntos
Cucumis melo/química , Estresse Salino , Potássio/administração & dosagem , Minerais/análiseRESUMO
INTRODUCTION: Human visceral leishmaniasis is considered a major public health problem in the municipality of Cametá, Pará, Brazil. METHODS: This ecological study was conducted using data obtained from official Brazilian agencies. Spatial analysis of the variables was performed using the kernel interpolation technique and the bivariate Global Moran's Index. RESULTS: The spatial distribution of the disease was not homogeneous, and it was associated with socio-environmental risk factors and public policies. CONCLUSIONS: Different relationships were observed between the variables studied and disease occurrence.
Assuntos
Leishmaniose Visceral , Brasil/epidemiologia , Cidades , Humanos , Incidência , Leishmaniose Visceral/diagnóstico , Leishmaniose Visceral/epidemiologia , Análise EspacialRESUMO
Neoglaziovia variegata (Arruda) Mez (Bromeliaceae) is a medicinal plant popularly known as "caroá." The leaves are made up of highly resistant fibers, which is of great commercial value to the handicraft and textile industry. Some studies have demonstrated that ethanolic extract of N. variegata have gastroprotective properties. This study aimed to investigate the gastroprotective activity and cytoprotective mechanisms of ethyl acetate (Nv-AcOEt), hexane (Nv-Hex), and chloroform (Nv-CHCl3) fractions of N. variegata leaves. The gastroprotective activity of Nv-AcOEt, Nv-Hex, and Nv-CHCl3 was evaluated using the ethanol and ethanol/HCl-induced gastric injury model. To elucidate the gastroprotective mechanisms, the functions of prostaglandins (PGs), nitric oxide (NO), and KATP channels were evaluated. In addition, the nonprotein sulfhydryl groups and the mucus content in the gastric tissues were analyzed. All fractions of N. variegata leaves at oral doses of 100, 200, and 400 mg/kg significantly decreased ethanol and ethanol/HCl-induced gastric lesions, leading to gastroprotection, accompanied by an increase in reduced glutathione (GSH) and gastric mucus. Gastroprotective activity of Nv-AcOEt was inhibited after pretreatment with ibuprofen and N(G)-nitro-L-arginine (L-NOARG). Gastroprotective effect of Nv-Hex and Nv-CHCl3 was also inhibited after pretreatment with L-NOARG and with glibenclamide. The results indicate that N. variegata (Arruda) Mez exhibits promising gastroprotective activity with the possible participation of NO, PGs, mucus, sulfhydryl groups, and KATP.
Assuntos
Antiulcerosos , Bromeliaceae , Úlcera Gástrica , Animais , Antiulcerosos/uso terapêutico , Mucosa Gástrica , Camundongos , Extratos Vegetais/uso terapêutico , Ratos , Úlcera Gástrica/tratamento farmacológicoRESUMO
Abstract INTRODUCTION: Human visceral leishmaniasis is considered a major public health problem in the municipality of Cametá, Pará, Brazil. METHODS: This ecological study was conducted using data obtained from official Brazilian agencies. Spatial analysis of the variables was performed using the kernel interpolation technique and the bivariate Global Moran's Index. RESULTS: The spatial distribution of the disease was not homogeneous, and it was associated with socio-environmental risk factors and public policies. CONCLUSIONS: Different relationships were observed between the variables studied and disease occurrence.
Assuntos
Humanos , Leishmaniose Visceral/diagnóstico , Leishmaniose Visceral/epidemiologia , Brasil/epidemiologia , Incidência , Cidades , Análise EspacialRESUMO
The use of saline water is one of the major challenges of agriculture, as it can cause nutritional imbalances and thus reduce crop yield. This study proposes to examine the efficiency of potassium nutrition as a salt stress-mitigating agent in melon grown in a protected environment. The experiment was laid out in a randomized-block design with ten treatments in a 2 × 4 factorial arrangement represented by two melon cultivars (McLaren and SV1044MF) and four nutrient solutions (S1 - standard nutrient solution, 2.5 dS m-1; S2 - nutrient solution salinized with NaCl, 5.0 dS m-1; S3 - nutrient solution salinized with NaCl + 50% K, 6.5 dS m-1; and S4 - nutrient solution salinized with NaCl + 100% K, 7.5 dS m-1). Yield (average fruit weight, production, fruit diameter, internal cavity, and pulp thickness), quality (pulp firmness, total sugars, soluble solids [SS], vitamin C, pH, titratable acidity [TA] and SS/TA ratio) and nutritional (K, Na and K/Na ratio) variables were evaluated. Plants fertigated with standard nutrient solution showed the highest values for fruit weight (1,190.6 g), production (2,381.3 g per plant), fruit diameter (13.6 cm) and pulp thickness (2.6 cm). Cultivar McLaren produced heavier fruits (931.4 g) with larger diameter (12.4 cm) and pulp thickness (2.4 cm). The addition of NaCl to nutrient solution induced a reduction in the yield variables but did not influence fruit quality. The addition of extra K to salinized nutrient solution did not mitigate the deleterious effect of salinity on the yield of melon.(AU)
O uso de água salina é um dos principais desafios na produção agrícola, pois pode provocar desbalanço nutricional e, consequentemente, reduzir o rendimento das culturas. Este trabalho teve como objetivo avaliar a eficiência da nutrição potássica como agente atenuador do estresse salino no meloeiro cultivado em ambiente protegido. O delineamento experimental utilizado foi em blocos casualizados, com dez tratamentos arranjados em esquema fatorial 2 × 4, sendo dois cultivares de meloeiro (McLaren e SV1044MF) e quatro soluções nutritivas (S1- solução nutritiva padrão, 2,5 dS m-1; S2 solução nutritiva salinizada com NaCl, 5,0 dS m-1; S3 solução nutritiva salinizada com NaCl + 50% K, 6,5 dS m-1; S4 - solução nutritiva salinizada com NaCl + 100% K, 7,5 dS m-1). As variáveis de rendimento (peso médio de fruto, produção, diâmetro de fruto, cavidade interna e espessura de polpa), qualidade (firmeza de polpa, açúcares totais, sólidos solúveis, vitamina C, pH, acidez titulável e razão SS/AT) e nutrição (K, Na e razão K/Na) foram avaliadas. Plantas fertirrigadas com solução nutritiva padrão apresentaram maiores valores para peso de frutos (1.190,6 g), produção (2.381,3 g planta-1), diâmetro de fruto (13,6 cm) e espessura de polpa (2,6 cm). O cv. McLaren apresentou frutos mais pesados (931,4 g), com maior diâmetro (12,4 cm) e espessura de polpa (2,4 cm). A adição de NaCl na solução nutritiva provocou redução nas variáveis de rendimento, mas não influenciou a qualidade dos frutos. A adição extra de K em solução nutritiva salinizada não atenuou o efeito deletério da salinidade sobre o rendimento do meloeiro.(AU)
Assuntos
Potássio , Ácido Ascórbico , Cucurbitaceae , Estresse Salino , Ciências da Nutrição , Produção AgrícolaRESUMO
Hemorrhagic cystitis (HC) is the major dose-limiting adverse effect of the clinical use ifosfamide (IFOS). The incidence of this side effect can be as high as 75%. Mesna has been used to reduce the risk of HC, although 5% of patients who get IFOS treatment may still suffer from HC. In previous studies, our group demonstrated that α-phellandrene (α-PHE) possesses anti-inflammatory activity, which opens the door for its study in the attenuation of HC. The objective of this study was to investigate the potential uroprotective effect of the α-PHE in the mouse model of IFOS-induced HC. In order to analyze the reduction of the urothelial damage, the bladder wet weight, hemoglobin content, and the Evans blue dye extravasation from the bladder matrix were evaluated. To investigate the involvement of neutrophil migration and lipid peroxidation and involvement of enzymatic and endogenous non-enzymatic antioxidants, the tissue markers myeloperoxidase (MPO), malondialdehyde, nitrite/nitrate (NOx), superoxide dismutase (SOD), and reduced glutathione (GSH) were evaluated. TNF-α and IL-1ß were measured by ELISA immunoassay technique. The results show that pretreatment with α-PHE significantly reduced urothelial damage that was accompanied by a decrease in the activity of MPO, MDA, and NOx levels and prevention of the depletion of SOD and GSH in bladder tissues. In the assessment of cytokines, α-PHE was able to significantly reduce TNF-α level. However, it does not affect the activities of IL-1ß. These data confirm that α-PHE exerts potent anti-inflammatory properties and demonstrates that α-PHE represents a promising therapeutic option for this pathological condition.
Assuntos
Monoterpenos Cicloexânicos/uso terapêutico , Cistite/prevenção & controle , Hemorragia/prevenção & controle , Ifosfamida/toxicidade , Estresse Oxidativo/efeitos dos fármacos , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Animais , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/uso terapêutico , Antineoplásicos Alquilantes/toxicidade , Monoterpenos Cicloexânicos/farmacologia , Cistite/induzido quimicamente , Cistite/metabolismo , Relação Dose-Resposta a Droga , Hemorragia/induzido quimicamente , Hemorragia/metabolismo , Masculino , Camundongos , Estresse Oxidativo/fisiologia , Fator de Necrose Tumoral alfa/metabolismoRESUMO
Few research on the entomofauna associated to forest plantations with Swietenia macrophylla (King) in Brazil has been reported. The aim of this study was to analyze the Coleoptera communities in forest ecosystems with S. macrophylla, Brazilian mahogany, with emphasis on the diversity of families and the main functional groups. The insects were collected through pitfall traps in three forest ecosystems: monoculture, consortium and forest enriched with Brazilian mahogany, during dry and rainy periods in two consecutive years. The identification of the captured insects occurred in the entomology laboratory of the Federal Rural University of Amazonia. The analysis was performed through Past Paleontological Statistic 3.14 and ANAFAU, where the difference was considered significant only when p ? 0.05. 11,358 specimens from 21 families were captured, of which 8,058 were sampled in the rainy season and 3,299 in the dry season. There was influence of seasonality and types of forest ecosystems during collection. The families Nitidulidae, Staphylinidae, Carabidae and Meloidae presented greater abundance and richness in the complex ecosystems. Anobiidae, Cerambycidae, Bostrichidae, Brentidae, Buprestidae, Curculionidae, Elateridae, Chrysomelidae and Lagriidae were considered to be pests and common to all studied ecosystems; however, the families Nitidulidae, Scarabaeidae, Tenebrionidae and Passalidae had the function of decomposers; Carabidae, Coccinellidae, Histeridae, Meloidae, Staphylinidae, Cantharidae and Hydrophilidae were the predators.
Poucas pesquisas sobre a entomofauna associada a plantios florestais com Swietenia macrophylla (King), no Brasil, tem sido reportadas. Pretendeu-se estudar a prospecção de comunidades de Coleópteros em ecossistemas florestais com S. macrophylla, mogno brasileiro, com ênfase na diversidade de famílias e dos principais grupos funcionais. A coleta dos insetos foi através de armadilhas do tipo pitfall traps em três ecossistemas florestais: monocultivo, consórcio e floresta enriquecida com mogno brasileiro, durante os períodos seco e chuvoso em dois anos consecutivos. A identificação dos insetos capturados ocorreu no laboratório de entomologia da Universidade Federal Rural da Amazônia. As análises foram realizadas através dos programas Past Paleontological Statistic 3,14, e ANAFAU, onde a diferença foi considerada significativa apenas quando p ≤ 0,05. Foram capturados 11.358 espécimes de 21 famílias, sendo 8.058 indivíduos no período chuvoso e 3.299 no seco. Houve influência da sazonalidade e dos tipos de ecossistemas florestais durante a coleta. As famílias Nitidulidae, Staphylinidae, Carabidae e Meloidae apresentaram maior abundância e riqueza nos ecossistemas mais complexos. Anobiidae, Cerambycidae, Bostrichidae, Brentidae, Buprestidae, Curculionidae, Elateridae, Chrysomelidae e Lagriidae foram as famílias consideradas pragas e comuns a todos os ecossistemas estudados, entretanto, as famílias Nitidulidae, Scarabaeidae, Tenebrionidae e Passalidae tiveram função de decompositores; Carabidae, Coccinellidae, Histeridae, Meloidae, Staphylinidae, Cantharidae e Hydrophilidae foram os predadores.
Assuntos
Animais , Besouros/classificação , Ecossistema , Florestas , Meliaceae , Biodiversidade , BrasilRESUMO
Few research on the entomofauna associated to forest plantations with Swietenia macrophylla (King) in Brazil has been reported. The aim of this study was to analyze the Coleoptera communities in forest ecosystems with S. macrophylla, Brazilian mahogany, with emphasis on the diversity of families and the main functional groups. The insects were collected through pitfall traps in three forest ecosystems: monoculture, consortium and forest enriched with Brazilian mahogany, during dry and rainy periods in two consecutive years. The identification of the captured insects occurred in the entomology laboratory of the Federal Rural University of Amazonia. The analysis was performed through Past Paleontological Statistic 3.14 and ANAFAU, where the difference was considered significant only when p ? 0.05. 11,358 specimens from 21 families were captured, of which 8,058 were sampled in the rainy season and 3,299 in the dry season. There was influence of seasonality and types of forest ecosystems during collection. The families Nitidulidae, Staphylinidae, Carabidae and Meloidae presented greater abundance and richness in the complex ecosystems. Anobiidae, Cerambycidae, Bostrichidae, Brentidae, Buprestidae, Curculionidae, Elateridae, Chrysomelidae and Lagriidae were considered to be pests and common to all studied ecosystems; however, the families Nitidulidae, Scarabaeidae, Tenebrionidae and Passalidae had the function of decomposers; Carabidae, Coccinellidae, Histeridae, Meloidae, Staphylinidae, Cantharidae and Hydrophilidae were the predators.(AU)
Poucas pesquisas sobre a entomofauna associada a plantios florestais com Swietenia macrophylla (King), no Brasil, tem sido reportadas. Pretendeu-se estudar a prospecção de comunidades de Coleópteros em ecossistemas florestais com S. macrophylla, mogno brasileiro, com ênfase na diversidade de famílias e dos principais grupos funcionais. A coleta dos insetos foi através de armadilhas do tipo pitfall traps em três ecossistemas florestais: monocultivo, consórcio e floresta enriquecida com mogno brasileiro, durante os períodos seco e chuvoso em dois anos consecutivos. A identificação dos insetos capturados ocorreu no laboratório de entomologia da Universidade Federal Rural da Amazônia. As análises foram realizadas através dos programas Past Paleontological Statistic 3,14, e ANAFAU, onde a diferença foi considerada significativa apenas quando p ≤ 0,05. Foram capturados 11.358 espécimes de 21 famílias, sendo 8.058 indivíduos no período chuvoso e 3.299 no seco. Houve influência da sazonalidade e dos tipos de ecossistemas florestais durante a coleta. As famílias Nitidulidae, Staphylinidae, Carabidae e Meloidae apresentaram maior abundância e riqueza nos ecossistemas mais complexos. Anobiidae, Cerambycidae, Bostrichidae, Brentidae, Buprestidae, Curculionidae, Elateridae, Chrysomelidae e Lagriidae foram as famílias consideradas pragas e comuns a todos os ecossistemas estudados, entretanto, as famílias Nitidulidae, Scarabaeidae, Tenebrionidae e Passalidae tiveram função de decompositores; Carabidae, Coccinellidae, Histeridae, Meloidae, Staphylinidae, Cantharidae e Hydrophilidae foram os predadores.(AU)
Assuntos
Animais , Meliaceae , Ecossistema , Florestas , Besouros/classificação , Biodiversidade , BrasilRESUMO
BACKGROUND: It is well known that medicinal plants and their products are relevant candidates for the treatment of inflammatory conditions. Ethyl p-coumarate is a phenylpropanoid that has similar structure to others anti-inflammatory and antioxidant substances. However, these activities have never been tested. PURPOSE: The aim of this study was to investigate the effect of ethyl p-coumarate on inflammatory and oxidative stress parameters. STUDY DESIGN: This is an experimental study to evaluate the anti-inflammatory and antioxidant activities of ethyl p-coumarate in acute and chronic models of inflammation. METHODS: The anti-inflammatory effect of ethyl p-coumarate was evaluated in Swiss mice by carrageenan-induced paw edema model (1%, 50 µl), followed by histological analysis, and edema induced by compound 48/80 (12 µg/paw), histamine (100 ⯵g/paw), serotonin (100 µg/paw) and prostaglandin E2 (3 nmol/paw) in comparison to indomethacin treatment (10 mg/kg, p.o.). In addition, peritonitis was induced by carrageenan (500 µg/cavity) to neutrophil and total leukocytes counting, myeloperoxidase (MPO), interleukin 6 (IL-6) and 8 (IL-8), nitrite (NO2-), glutathione (GSH) and malondialdehyde (MDA) measurements. The arthritis model was induced with Freund's complete adjuvant (id. 0.1â¯ml) in female Wistar rats, with measurement of joint diameter and X-ray. Changes in gastric tissue of Swiss mice were analyzed in comparison to indomethacin (20 â¯mg/kg, p.o.). RESULTS: After treatment with ethyl p-coumarate, the animals had no apparent toxic effects, and significantly inhibited paw edema induced by edematogenic agents, neutrophil (pâ¯<â¯0.001) and total leukocyte (pâ¯<â¯0.001) migration, MPO (pâ¯<â¯0.01), IL-6 (pâ¯<â¯0.05) and IL-8 (pâ¯<â¯0.5), MDA (pâ¯<â¯0.5), GSH (pâ¯<â¯0.5), NO2- (pâ¯<â¯0.001), joint thickness and bones changes. Furthermore, were not observed significant formation of gastric lesions. CONCLUSION: Taken together, these results suggest that ethyl p-coumarate exhibits anti-inflammatory activity through the inhibition of inflammatory mediators and leukocyte migration without causing gastric lesions.