RESUMO
Foram realizados testes de susceptibilidade "in vitro" com varias amostras de agentes, isoladas de pacientes com cromomicose frente a 5-fluorocitosina e butil-simpatol (Vasculat), nas concentracoes de 0,1, 1,0, 5,0, 10,0 mcg/ml. Em alguns casos, em que se verificou resistencia a 5-fluorocitosina, a concentracao desta chegou a 100,0 mcg/ml
Assuntos
Cromoblastomicose/fisiopatologia , Cromoblastomicose/genética , Cromoblastomicose/imunologia , Cromoblastomicose/tratamento farmacológico , Flucitosina/análise , Flucitosina/farmacologia , Flucitosina/imunologia , Flucitosina/química , Micoses/genética , Micoses/imunologia , Micoses/reabilitação , Micoses/terapiaRESUMO
In vitro 5-fluorocytosine sensitivity tests of strains were isolated from chromomycosis patients undergoing therapy. Tests were rountunely performed for 0.1, 1.0, 5.0 and 10.0 ug/ml 5-fluorocytosine concentrations. In two cases resistence could be demonstrated up to 60.0 and 100.0 ug/ml. Fungistatic activity of 5-fluorocytosine against the agents of chromomycosis was confirmed. Sensitivity tests are useful to detect resistance which may occur during treatment. They are also helpful for guiding the clinician in the establishment of new therapeutic achedules