RESUMO
It has been described that febrile seizures during infancy increase risk of subsequent non-febrile seizures during the adulthood. However, latency period between febrile seizure and the onset of the first spontaneous seizure has not been evaluated. The present study was designed to investigate the susceptibility to subsequent seizures in immature rats that had experienced early-life hyperthermic seizures and before they achieved the adult age. The results were compared with those induced by hyperthermia alone. Pentylenetetrazol (PTZ) was applied 24h or 20 days after hyperthermic seizures or hyperthermia were induced in 10-day-old rats by a regulated stream of moderately heated air. One day after hyperthermic seizures or hyperthermia, animals demonstrated enhanced latency to the PTZ-induced myoclonic (88% and 53%, respectively), clonic (60% and 60%, respectively) and tonic seizures (233% and 659%, respectively). The incidence of myoclonic and clonic seizures was similar to that in control group (100%). However, hyperthermic seizures reduced (50%) the incidence of tonic seizures. Twenty days after hyperthermic seizures there was an augmented latency to tonic seizures (123%) and reduced incidence for all the PTZ-induced seizures (71% myoclonic; 71% clonic seizures; 57% tonic seizures) when compared with control group (100%). In contrast, hyperthermia enhanced only the latency to myoclonic (133%) and clonic seizures (659%). Our data indicate that hyperthermic seizures or hyperthermia induces a protective effect against PTZ-induced seizures during a latency period. A possible involvement of gamma-aminobutyric acid (GABA) system is discussed.
Assuntos
Febre/fisiopatologia , Convulsões/induzido quimicamente , Animais , Animais Recém-Nascidos , Convulsivantes/farmacologia , Modelos Animais de Doenças , Feminino , Masculino , Pentilenotetrazol/farmacologia , Gravidez , Ratos , Ratos Sprague-Dawley , Tempo de Reação/efeitos dos fármacos , Tempo de Reação/fisiologia , Convulsões/classificação , Fatores de TempoAssuntos
Alérgenos , Hipersensibilidade Alimentar/etiologia , Plantas , Verduras/efeitos adversos , Humanos , México , Plantas/imunologia , Poaceae , PólenRESUMO
A descriptive analysis was made including the possible plants capable of producing an allergic reaction with pollen grains. We worked with 106 species from 30 families and 79 genera; only 57 species contributed to the collection with prepared pollen grains. In the same manner, morphologic descriptions of the pollen grains were conducted. Clinical charts were reviewed, selecting those patients who reacted positively to some type of pollen (1101 patients) and to some kind of food. This was corroborated by the ingestion of vegetal origin foods. The gramineous, leguminous, rosaceae, and solanaceae were the most important group of vegetal-originating foods which caused a positive reaction due to their ingestion and a skin reaction in 37.52% of the patients.