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Introducción: El cáncer cérvico uterino es la segunda neoplasia más común en mujeres en el mundo. Una buena correlación entre las pruebas de tamizaje, diagnóstico y tratamiento de las lesiones cervicales optimiza su manejo, evita procedimientos innecesarios y maximiza recursos disponibles. Objetivo: Identificar la relación entre los métodos diagnósticos de las patologías del cuello uterino. Métodos: Se realizó un estudio observacional, descriptivo, transversal y prospectivo en el Hospital Provincial Camilo Cienfuegos de Sancti Spíritus, desde septiembre de 2015 a septiembre de 2017. Se tomó una población de 1172 pacientes de la consulta de patología de cuello uterino según los criterios de la investigación. Los métodos científicos fueron: de nivel teórico, empírico-experimental y matemático-estadístico. Se asumieron las variables: edad, factores de riesgo asociados, sintomatología, citología, colposcopia y biopsia. Resultados: El grupo de edad que con mayor frecuencia se presentó estuvo comprendido entre 26 y 35 años de edad. Los principales factores de riesgo asociados fueron: edad de inicio de las relaciones sexuales antes de los 18 años, virus del papiloma humano, paridad de más de dos hijos y antecedentes familiares de alguna patología de cuello. La sintomatología destacada fue el sangramiento poscoital e intermenstrual. Los resultados de los métodos diagnósticos fueron: virus del papiloma humano y displasia leve, tanto en la citología como en la biopsia, y lesiones de bajo grado en la colposcopia. Conclusiones: La asociación entre los métodos diagnósticos estudiados mostró una buena correlación citocolposcópica y colpohistológica, con diagnóstico de confirmación principalmente ante lesiones de alto grado(AU)
Introduction: Cervical cancer is the second most common neoplasm in women in the world. Good correlation between screening tests, diagnosis and treatment of cervical lesions optimizes management, avoiding unnecessary procedures and maximizing available resources. Objective: To identify the relationship between the diagnostic methods of cervical pathologies. Methods: An observational, descriptive, cross-sectional and prospective study was conducted at Camilo Cienfuegos Provincial Hospital in Sancti Spíritus, from September 2015 to September 2017. A population of 1172 patients was taken from the cervical pathology clinic according to the research criteria. The scientific methods were theoretical, empirical-experimental and mathematical-statistical. The assumed variables were age, associated risk factors, symptomatology, cytology, colposcopy and biopsy. Results: The age group that most frequently appeared was ages between 26 and 35 years. The main associated risk factors were age of first sexual intercourse before 18 years old, human papillomavirus, parity of more than two children and family history of some cervix pathology. The outstanding symptomatology was postcoital and intermenstrual bleeding. The results of the diagnostic methods were human papillomavirus and mild dysplasia, both in cytology and biopsy, and low-grade colposcopy lesions. Conclusions: The association between the diagnostic methods studied showed good cytocolposcopic and colpohistological correlation, with confirmation diagnosis mainly in cases of high-grade lesions(AU)
Assuntos
Humanos , Feminino , Adolescente , Adulto , Doenças do Colo do Útero/patologia , Displasia do Colo do Útero/diagnóstico , Colposcopia/métodos , Epidemiologia Descritiva , Estudos Transversais , Estudos ProspectivosRESUMO
Klippel-Trenaunay syndrome is a rare disease that includes the triad of malformation of vascular capillaries, varicose veins and/or venous malformation and hypertrophy of soft or bony tissues. Its presence during pregnancy poses an anesthetic challenge due to the high obstetric risk due to thromboembolic and/or hemorrhagic phenomena. We present the case of a pregnant woman with the diagnosis of Klippel-Trenaunay syndrome announced for elective cesarean section. Our objective is to expose the anesthetic management carried out and to propose a strategic guide for anesthesiologists.
El síndrome de Klippel-Trenaunay es una rara enfermedad que comprende la tríada de malformación de capilares vasculares, venas varicosas y/o malformación venosa e hipertrofia de tejidos blandos u óseos. Su presencia durante la gestación supone un reto anestésico por el alto riesgo obstétrico debido a fenómenos tromboembólicos y/o hemorrágicos. Presentamos el caso de una embarazada con el diagnóstico de síndrome de Klippel-Trenaunay anunciada para cesárea electiva. Nuestro objetivo es exponer el manejo anestésico realizado y proponer una guía estratégica para los anestesiólogo
Assuntos
Humanos , Feminino , Adulto , Complicações Cardiovasculares na Gravidez , Cesárea/métodos , Síndrome de Klippel-Trenaunay-Weber/complicações , Anestesia Obstétrica/métodos , Anestesia por Condução/métodosRESUMO
In recent years, biomineralization process is being employed in development of bioconcrete, which is emerging as a sustainable method to enhance the durability of concrete by way of increasing compressive strength and reducing the chloride permeability. In this study, different bacterial strains isolated from the soils of the Laguna Region of Mexico were selected for further study. ACRN5 strain demonstrated higher urease activity than other strains, and the optimum substrate concentration, pH, and temperature were 120 mM, pH 8, and 25 °C, respectively. Further, Km and Vmax of urease activity of ACRN5 were 21.38 mM and 0.212 mM min-1, respectively. It was observed that addition of ACRN5 at 105 cells ml-1 to cement-water mixture significantly increased (14.94%) in compressive strength after 36 days of curing and reduced chloride penetration. Deposition of calcite in bio-mortars was observed in scanning electron microscopy and energy dispersive X-ray diffraction spectrometry analyses. Results of this study demonstrated the role of microbially induced calcium carbonate precipitation in improving the physico-mechanical properties of bio-mortars.
Assuntos
Bactérias/metabolismo , Biomineralização , Carbonato de Cálcio/metabolismo , Materiais de Construção/análise , Carbonato de Cálcio/análise , Força Compressiva , Impedância Elétrica , México , Microscopia Eletrônica de Varredura , Permeabilidade , Microbiologia do Solo , Difração de Raios XRESUMO
A new, direct, and diastereoselective synthesis of activated 2,3,4,6-tetrasubstituted tetrahydro-2H-pyrans is described. In this reaction, iron(III) catalyzed an SN2'-Prins cyclization tandem process leading to the creation of three new stereocenters in one single step. These activated tetrahydro-2H-pyran units are easily derivatizable through CuAAC conjugations in order to generate multifunctionalized complex molecules. DFT calculations support the in situ SN2' reaction as a preliminary step in the Prins cyclization.
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Introducción. El 11 de marzo de 1847, el Dr. Vicente Antonio de Castro y Bermúdez, por primera en vez en Cuba y Latinoamérica administró anestesia con vapores de éter para un procedimiento quirúrgico. Objetivo. Realizar una puesta al día sobre el actuar científico, intelectual y patriótico del sabio cubano quien administró la primera anestesia en Cuba. Desarrollo. Se realizó una minuciosa búsqueda de la vida y obra del Dr. Vicente Antonio de Castro y Bermúdez, de la cual se destacan detalles importantes de su vida; no sólo de su actividad médico científica, sino también, patriótica y literaria. Conclusiones. Sirva esta reseña histórica como homenaje al aniversario de la administración de la primera anestesia en Cuba y Latinoamérica.
The March 11, 1847, Vicente Antonio de Castro y Bermúdez M.D for the first time in Cuba and in Latin America, administered anesthesia with ether steams for a surgical procedure. Objective: To made an update on the surgical, scientific, intellectual and patriotic act of the Cuban wise who administered the first anesthesia in Cuba. Development: A deep search on the life and work of Vicente Antonio de Castro Bermúdez M.D. from which are emphasized significant details of his life, not only of his scientific and medical activity, but also, patriotic and literary. Conclusions: This historical review is a tribute to anniversary of the administration of the first anesthesia in Cuba and in Latin America.
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Introducción: El dolor postoperatorio es constante e infratratado en los pacientes intervenidos quirúrgicamente por urgencias traumatológicas. La utilización de opioides es referencia de la mayoría de las técnicas de analgesia postoperatoria. Objetivo: Describir los efectos de la infusión intravenosa contínua de tramadol en los procedimientos quirúrgicos traumatológicos de urgencia. Diseño metodológico: Estudio descriptivo, prospectivo y longitudinal en 83 pacientes sometidos a cirugía traumatológica de urgencia y seleccionados aleatoriamente. Se estudiaron las variables: tensión arterial sistólica y diastólica, frecuencia cardiaca, frecuencia respiratoria, saturación periférica de oxígeno, evolución del dolor postoperatorio, analgesia de rescate y efectos colaterales. Resultados: El tratamiento ofrecido en la investigación proporcionó una estabilidad hemodinámica y respiratoria con una potencia analgésica de acuerdo a su farmacocinética clínica y a su biodisponibilidad. Aparecieron efectos colaterales menores (náuseas, vómitos y sedación) por poseer menor afinidad por los receptores opioides que el compuesto original, la morfina. Conclusión: La descripción del tramadol en infusión continua intravenosa permitió mostrar un método analgésico efectivo en la cirugía urgente traumatológica.
Postoperative pain is constant and it is undertreated in patients underwent surgery from traumatic emergencies. Opioids use is reference of most of postoperative analgesia techniques. Aim: To describe the effects of Tramadol continuous intravenous perfusion on emergency traumatic surgical procedures. Methodological design: A longitudinal, prospective and descriptive study made in 83 patients underwent emergency traumatic surgery, randomly selected. Following variables were studied: systolic and diastolic arterial tension, frequently of cardiac origin, respiratory frequency, peripheral saturation oxygen, postoperative pain course, rescue analgesia, and side effects. Results: Treatment offered in this research allowed a hemodynamic and respiratory stability with an analgesic power according its clinical pharmacokinetics, and to its bioavailability. There were minor side effects (nauseas, vomiting and sedation) due to the lower affinity to opioids receptors than original compound, the morphine. Conclusions: Description of Tramadol intravenous continuous perfusion allowed showing an effective analgesic method in traumatic urgent surgery.
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Aleukemic leukemia cutis is an extremely rare clinical presentation in patients who eventually develop acute leukemia, usually of monocytic lineage. This condition is associated with a very poor prognosis and is often difficult to diagnose. We report a case of a 33 years old female with leukemia cutis preceding the onset of acute monocytic leukemia by four months. The patient received induction and consolidation chemotherapy followed by allogeneic bone marrow transplant and has been free of disease for six years. To our knowledge, this is the first documented case in Puerto Rico with the diagnosis of leukemia cutis preceding acute monocytic leukemia.