RESUMO
UNLABELLED: Several studies have demonstrated an inverse relation between serum selenium levels (Se) and advanced prostate cancer (PCa). OBJECTIVE: To determine and compare selenium plasma levels in patients with different prostatic pathologies. MATERIAL AND METHODS: It is a transversal, descriptive and comparative study. A sample of 64 men between 50 and 80 years old were selected for the study between 2007 and 2009. All volunteers underwent a digital rectal examination, prostate specific antigen level, ultrasound and transrectal prostate biopsy (12-14 chips). Prostate cancer was subclassified according to Gleason Score. Selenium was determined indirectly by serum Glutathione peroxidase (Kit Ransel, Randox SRL, Crumlin, UK). Statistical analysis was performed using ANOVA I (p<0.05). RESULTS: Glutathione Peroxidase level was 33.75+/-2.36 mg/ml in control patients. A decrease of 31.6% was observed in patients with BPH (23.08+/-1.57 mg/ml) and of (63.6%) in subjects with prostate cancer (12.28+/-1.03 mg/ml) (p<0,0001). There was no correlation with the Gleason Score. CONCLUSION: Serum Seleniun is lower in patients with prostatic pathologies being even more important in cancer patients regardless the Gleason Score.
Assuntos
Doenças Prostáticas/sangue , Neoplasias da Próstata/sangue , Selênio/sangue , Estudos Transversais , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
In a family in which the mother was a healthy HBsAg and anti HBc carrier, and the father had a chronic persistent hepatitis with anti HBs and anti HBc positive, the development of neonatal cirrhosis in two of the children was proved to be present. One of the girls was an anti HBs carrier (anti HBc was not determined) and the other had positive anti HBs and anti HBc. Both died and the diagnosis of cirrhosis was confirmed. The two healthy daughters were anti HBc carriers.
Assuntos
Portador Sadio/imunologia , Vírus da Hepatite B/patogenicidade , Hepatite B/genética , Doenças do Recém-Nascido , Cirrose Hepática/genética , Anticorpos Antivirais/isolamento & purificação , Formação de Anticorpos , Argentina , Criança , Doença Crônica , Feminino , Hepatite/transmissão , Hepatite B/transmissão , Antígenos de Superfície da Hepatite B/isolamento & purificação , Humanos , Recém-Nascido , Doenças do Recém-Nascido/etiologia , Cirrose Hepática/transmissão , Masculino , Linhagem , GravidezRESUMO
PIP: In order to study the cyclic variations in the immunoglobulins of the human vaginal fluid, vaginal secretions were obtained from 12 volunteers during the follicular phase (Days 7-12 of cycle) and from 12 during the luteal phase (Days 18-25 of cycle). At follicular phase, immunoglobulin G was present in all samples, and immunoglobulin A similar to serum immunoglobulin A was found occasionally. At luteal phase, immunoglobulin G apparently occurred at a greater concentration, and another immunoglobulin A, different from the serum type, was found. No immunoglobulin M was detected in any sample. It is postulated that the cyclic variations in immunoglobulins of human vaginal fluid, which occur under normal conditions could be 1) related to the plasma cells found in the vaginal mucosa and 2) mediated by the ovarian hormones.^ieng