RESUMO
Utilizaram-se 48 porcas primíparas, de genética PIC, com média de peso de 185,03±15,78kg, para avaliar diferentes níveis de energia digestível (3.350, 3.500, 3.650 e 3.800kcal/kg) na ração, durante a lactação (19,98±1,04 dias). Utilizou-se o delineamento experimental inteiramente casualizado, com quatro tratamentos e 12 repetições, sendo a porca considerada a unidade experimental. O consumo total de ração não variou entre os animais dos tratamentos, sendo que as porcas consumiram em média 4,0kg de ração por dia. O consumo de energia digestível aumentou de forma linear, de acordo com o nível de energia na ração. Não se observou efeito do nível de energia da ração sobre a mobilização de reserva corporal, as características reprodutivas e o nível de insulina no soro das porcas. Observou-se aumento linear do ganho de peso dos leitões em função do consumo de energia das porcas. Conclui-se que porcas primíparas em lactação exigem 3.800kcal/kg de ração, correspondente a um consumo de 14.307kcal/dia.(AU)
Forty-eight primiparous sows (PIC), weighting in average of 185.03±15.78kg, were used to evaluate different levels of digestible energy (3,350; 3,500; 3,650 and 3,800 kcal/kg) during lactation (19.98±1.04 days). A completely randomized design was used with four treatments, 12 replicates, being the sow considered as the experimental unit. The sows were daily fed with 4.0kg of the experimental diet. Energy intake increased linearly, according to the level of digestible energy in the diet. The energy level in the diet did not affect the mobilization of corporal reserve, the reproductive characteristics and the levels of insulin of the serum of the sows. Weight gain of piglets and litter increased linearly, according to the dietary energy levels. It was concluded that primiparous lactating sows need to intake at least 14,307kcal/day.(AU)
Assuntos
Animais , Feminino , Aumento de Peso , Ração Animal/análise , Lactação/metabolismo , SuínosRESUMO
Utilizaram-se 48 porcas primíparas, de genética PIC, com média de peso de 185,03±15,78kg, para avaliar diferentes níveis de energia digestível (3.350, 3.500, 3.650 e 3.800kcal/kg) na ração, durante a lactação (19,98±1,04 dias). Utilizou-se o delineamento experimental inteiramente casualizado, com quatro tratamentos e 12 repetições, sendo a porca considerada a unidade experimental. O consumo total de ração não variou entre os animais dos tratamentos, sendo que as porcas consumiram em média 4,0kg de ração por dia. O consumo de energia digestível aumentou de forma linear, de acordo com o nível de energia na ração. Não se observou efeito do nível de energia da ração sobre a mobilização de reserva corporal, as características reprodutivas e o nível de insulina no soro das porcas. Observou-se aumento linear do ganho de peso dos leitões em função do consumo de energia das porcas. Conclui-se que porcas primíparas em lactação exigem 3.800kcal/kg de ração, correspondente a um consumo de 14.307kcal/dia.
Assuntos
Animais , Feminino , Lactação/metabolismo , Ração Animal/análise , Suínos , Aumento de PesoRESUMO
Physalis angulata is a solanaceae widely used in folk medicine in various tropical countries in the world. We have previously described that seco-steroids (physalins) purified from P. angulata are potent inhibitors of macrophage activation, blocking the production of pro-inflammatory cytokines and LPS-induced lethality. Herein we investigated the immunomodulatory activities of these substances in lymphocyte proliferation and cytokine production and in transplantation. The addition of physalins B, F or G to concanavalin A-activated splenocyte cultures induced a concentration-dependent inhibition of proliferation. Physalin B also inhibited IL-2 production by Con A-activated spleen cells. The addition of 2 mug/ml physalin B to mixed lymphocyte reaction (MLR) caused a 100% inhibition of proliferation. More importantly, treatment of mice with physalin B, F or G prevented the rejection of allogeneic heterotopic heart transplant. Our results demonstrate the suppressive activity of physalins B, F and G in lymphocyte function and indicate the potential use of physalins as immunosuppressive agents for treatments of pathologies in which inhibition of immune responses is desired.
Assuntos
Rejeição de Enxerto/prevenção & controle , Transplante de Coração/imunologia , Imunossupressores/farmacologia , Linfócitos/efeitos dos fármacos , Physalis , Secoesteroides/farmacologia , Animais , Proliferação de Células/efeitos dos fármacos , Concanavalina A/farmacologia , Feminino , Rejeição de Enxerto/imunologia , Transplante de Coração/patologia , Interleucina-2/metabolismo , Linfócitos/imunologia , Linfócitos/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Camundongos Endogâmicos C3H , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Mifepristona/farmacologia , Baço/citologia , Baço/efeitos dos fármacos , Baço/imunologiaRESUMO
BACKGROUND: The complications associated with anterior craniofacial resections for benign and malignant tumors were reviewed in 104 patients treated between January 1981 and June 1996. METHODS: Information regarding patient characteristics, histologic type, history of prior therapy, extent of the disease, extent of surgical procedure, and type of reconstruction were entered in a microcomputer database. To better understand and stage postoperative complications, we divided them into early (<14 days) and late (>14 days) according to the time of presentation, into major and minor depending on the morbidity potential of complication, and into local and systemic ones. Comparison between risk factors associated with complications was made using chi-square analysis with Yates' correction for continuity. Survival analysis was performed using the Kaplan-Meier product limit method. RESULTS: There were 8 (7.6%) postoperative deaths, with only 1 occurring from systemic complications. Complications occurred in 53 (48.6%) patients. Local major complications occurred in 49 (45%) patients, local minor in 29 (26.6%), and systemic in 11 (10%). Early complications occurred in 40 (38.5%) patients and late complications in 13 (12.5%) patients. These complications developed during a period ranging from 1 day to 5 months. More than one complication occurred in a number of patients. Bacterial contamination leading to local septic complications was the principal cause of morbidity, accounting for 54.7% (29/53) of complications. Major complications included meningitis in 8 patients associated with cerebrospinal fluid leak in 7, cerebral abscess in 2, sepsis in 1, and subdural hemorrhage in 1, all of which resulted in death except for one case. The extent of the craniofacial resection (p = .011) was the most important factor associated with major complications. Invasion of the dura and the type of reconstruction of the anterior skull base were the most important factors related to cerebrospinal fluid leakage (p = .048 and p = .032) and meningitis (p = .011). CONCLUSION: Contemporary surgical approaches and methods of reconstruction have enabled skull base surgeons to extend their cranial base resections and increase the 5-year survival rates of patients. Nevertheless, significant complications persist. Knowledge and high index of suspicion together with early recognition of these complications are essential for effective management of patients undergoing craniofacial resection. The factors related to major complications found in this study stressed the need to develop more effective methods to prevent contamination of intracranial structures.
Assuntos
Carcinoma Basocelular/cirurgia , Carcinoma de Células Escamosas/cirurgia , Neoplasias de Cabeça e Pescoço/cirurgia , Complicações Pós-Operatórias , Neoplasias Cranianas/cirurgia , Adolescente , Adulto , Idoso , Carcinoma Basocelular/mortalidade , Carcinoma de Células Escamosas/mortalidade , Feminino , Neoplasias de Cabeça e Pescoço/mortalidade , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Neoplasias Cranianas/mortalidade , Análise de SobrevidaRESUMO
BACKGROUND: In order to assess whether near-total laryngectomy (NTL) could successfully reach the cure and preserve the voice in advanced laryngeal cancer, we studied 28 patients with T3/T4 squamous cell carcinoma of the larynx treated with NTL in our institution. METHODS: A retrospective analysis has been carried out from 1990 through 1994. We classified 24 patients as Stage III and 4 patients as Stage IV. All patients had lateral neck dissection. Survival was analyzed under the Kaplan-Meier method. RESULTS: Twenty-six patients achieved voice preservation. Two patients in the bilateral neck dissection group had a metastatic lymph node on the opposite side. No patient had local recurrence. Three patients died of the disease, and 1 patient was salvaged with neck dissection. Three-year disease-free survival was 85%. CONCLUSION: This technique is useful in the treatment of selected cases of advanced laryngeal cancer and achieves local control of the lesion in all cases. The survival is comparable with that of patients submitted to total laryngectomy, regarding the extent of lesion. Voice preservation can be achieved in most cases.