RESUMO
INTRODUCTION: Chronic kidney disease (CKD) is a priority problem due to its high prevalence. According to the modalities of renal replacement therapy, kidney transplantation (TR) offers to be the best alternative. TR presents multiple factors of dependence of success; among them is the management of the anatomical variants of the graft and the surgical decision on the basis of these. Therefore, the objective of this study is to determine the frequency of variants in the graft, its surgical management, and the impact on the functionality of the transplanted kidney. MATERIAL AND METHODS: This was an observational, retrospective study of patients in the renal transplant unit of the Siglo XXI National Medical Center from 2002-2016. The analysis begins in the description of the population doing bivariate analysis to establish relative risks. For variables with a central tendency, the parametric tests analysis of variance, Student t paired, and unpaired will be used. In the case of nominal variables, the proportion's difference will be estimated using the chi-square test, establishing significance when P is ≤ .05. SPSS 21 software was used. RESULTS: There were a total of 773 patients, with 576 transplants from living donors and 197 from deceased donors. In the case of the artery, a greater number of variants is observed-27.8% being alive versus 17.3% of the variants found in deceased donors. For the renal vein, 12.7% of the kidneys were taken from living donor vs 6.1% from deceased donors. This required one more day of hospitalization (6 vs 7 days of single vs multiple vessels); likewise, increases in immediate post-transplant infections were 5% for single vessels vs 8% in the case of multiple variants. CONCLUSIONS: The importance of knowing the anatomical variants prior to the TR allows them to plan the potential surgical maneuvers, decreasing the times aimed at improving the immediate functionality of the renal graft, while also considering the increase in hospital expenses due to the greater number of days of hospitalization.
Assuntos
Transplante de Rim/métodos , Rim/anormalidades , Transplantes/anormalidades , Adolescente , Adulto , Idoso , Feminino , Sobrevivência de Enxerto , Humanos , Masculino , México , Pessoa de Meia-Idade , Estudos Retrospectivos , Resultado do Tratamento , Adulto JovemRESUMO
OBJECTIVE OF THE STUDY: To measure the seric levels of zinc and copper in healthy and in hepatic damaged rats when an inflammatory stimulus is applied. RESEARCH DESIGN: 2 x 2 factorial design. SUBJECTS: Fisher *44 strain rats, healthy and with chronic hepatic damage. MEASUREMENTS: Serum levels of Zn and Cu were determined in the different experimental conditions. RESULTS: Basal Zn levels were found diminished in rats with hepatic damage as compared with healthy ones (p < 0.05), whereas Cu levels were found increased in hepatic damaged rats as compared with healthy ones (p < 0.05). Application of an inflammatory stimulus decreased Zn and increased Cu levels in healthy rats as compared to their basal conditions (p < 0.05), whereas no statistically significant variations were found in the group of rats with hepatic damage when comparing their serum levels before and after inflammatory stimulation. CONCLUSIONS: Rats with liver damage present alterations in their Zn and Cu levels under basal conditions. Rats with liver damage, submitted to an inflammatory stimulus, do not modify their serum Zn and Cu levels.