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Aedes albopictus is considered a potential vector of arboviruses in Colombia. Females and males naturally infected with dengue, Zika and chikungunya viruses have already been found in this country. We document the first record of Ae. albopictus in the Cordoba department, in North of Colombia. The finding was carried out during Ae. aegypti collection activities in the Ayapel, Montelibano, Planeta Rica, Pueblo Nuevo and Puerto Libertador municipalities. The entomological material was collected in water containers such as cement water tanks, tanks, bottles, tires, abandoned toilets, and plastic lids with natural water located in the intradomicile, peridomicile, and extra-domicile spaces of the homes. We collected 658 Ae. albopictus samples in the larva and pupa stages, and once these reached adulthood, we determined that 389 were female and 269 were male. This is the first record of the presence of Ae. albopictus in the Cordoba department.

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En el embarazo el requerimiento energético y de nutrientes aumentan, el déficit o el exceso puede afectar el estado nutricional de la madre y del neonato. Con el objetivo de determinar la frecuencia de malnutrición y su relación con complicaciones en mujeres embarazadas y sus recién nacidos que acuden al Hospital Distrital de Capiatá del Ministerio de Salud Pública y Bienestar Social, en el mes de febrero a agosto de 2022, se realizó un estudio observacional descriptivo de corte transverso retrospectivo que incluyó a 140 gestantes, de las cuales 64 presentaron complicaciones por malnutrición y 76 no presentaron ninguna complicación. La edad media fue de 26,9±6,6 años con un rango de edad de 15 a 40 años. Los resultados muestran que el 45.7% (n=64) de las gestantes presentaron complicaciones por malnutrición, el 51,6% presentó diabetes gestacional, anemia en el 29,7%, el 7,8% presentó anemia y diabetes gestacional, el otro 7,8% hipertensión arterial, el 1,6% manifestó hipertensión arterial y diabetes gestacional y el otro 1,6% presentó anemia, hipertensión arterial y diabetes gestacional. En relación a la evaluación nutricional al inicio y al final de la gestación en las gestantes con complicaciones hubo una leve disminución en los porcentajes de obesidad de 43,7% a 37,5% y un aumento del bajo peso de 11% a 20,3%. En cuanto al tipo de parto en las gestantes con complicaciones el 51,6% fue por cesárea (n=33), las cuales presentaron diabetes gestacional en el 54,5%, seguido de anemia en el 21,2%. Se comprobó un mayor porcentaje de sobrepeso y obesidad (29,7%) en los recién nacidos de madres con complicaciones. Se pudo evidenciar la frecuencia de malnutrición y complicaciones en casi la mitad de las gestantes, es preciso generar mayores estrategias en salud pública para prevenir la malnutrición y complicaciones en gestantes.

In pregnancy the energy and nutrient requirement increases, the deficit or excess can affect the nutritional status of the mother and the neonate. In order to determine the frequency of malnutrition and their relationship with complications in pregnant women and their newborns who go to the Capiata District Hospital of the Ministry of Public Health and Social Welfare, in the month of February to August 2022, a Descriptive observational study of retrospective cross -section that included 140 pregnant women, of which 64 presented complications for malnutrition and 76 did not present any complication. The Middle Ages was 26.9 ± 6.6 years with an age range of 15 to 40 years. The results show that 45.7% (n = 64) of pregnant women presented complications for malnutrition, 51.6% presented gestational diabetes, anemia in 29.7%, 7.8% presented anemia and gestational diabetes, the other 7.8% arterial hypertension, 1.6% expressed arterial hypertension and gestational diabetes and the other 1.6% presented anemia, arterial hypertension and gestational diabetes. In relation to nutritional evaluation at the beginning and at the end of pregnancy in pregnant women with complications there was a slight decrease in obesity percentages of 43.7% to 37.5% and an increase in low weight of 11% to 20, 3%. As for the type of childbirth in pregnant women with complications, 51.6%was due to caesarean section (n = 33), which presented gestational diabetes in 54.5%, followed by anemia in 21.2%. A higher percentage of overweight and obesity (29.7%) was proven in mother's newborns with complications. The frequency of malnutrition and complications could be evidenced in almost half of the pregnant women, it is necessary to generate greater public health strategies to prevent malnutrition and complications in pregnant women.

RESUMO

En el embarazo el requerimiento energético y de nutrientes aumentan, el déficit o el exceso puede afectar el estado nutricional de la madre y del neonato. Con el objetivo de determinar la frecuencia de malnutrición y su relación con complicaciones en mujeres embarazadas y sus recién nacidos que acuden al Hospital Distrital de Capiatá del Ministerio de Salud Pública y Bienestar Social, en el mes de febrero a agosto de 2022, se realizó un estudio observacional descriptivo de corte transverso retrospectivo que incluyó a 140 gestantes, de las cuales 64 presentaron complicaciones por malnutrición y 76 no presentaron ninguna complicación. La edad media fue de 26,9±6,6 años con un rango de edad de 15 a 40 años. Los resultados muestran que el 45.7% (n=64) de las gestantes presentaron complicaciones por malnutrición, el 51,6% presentó diabetes gestacional, anemia en el 29,7%, el 7,8% presentó anemia y diabetes gestacional, el otro 7,8% hipertensión arterial, el 1,6% manifestó hipertensión arterial y diabetes gestacional y el otro 1,6% presentó anemia, hipertensión arterial y diabetes gestacional. En relación a la evaluación nutricional al inicio y al final de la gestación en las gestantes con complicaciones hubo una leve disminución en los porcentajes de obesidad de 43,7% a 37,5% y un aumento del bajo peso de 11% a 20,3%. En cuanto al tipo de parto en las gestantes con complicaciones el 51,6% fue por cesárea (n=33), las cuales presentaron diabetes gestacional en el 54,5%, seguido de anemia en el 21,2%. Se comprobó un mayor porcentaje de sobrepeso y obesidad (29,7%) en los recién nacidos de madres con complicaciones. Se pudo evidenciar la frecuencia de malnutrición y complicaciones en casi la mitad de las gestantes, es preciso generar mayores estrategias en salud pública para prevenir la malnutrición y complicaciones en gestantes.

In pregnancy the energy and nutrient requirement increases, the deficit or excess can affect the nutritional status of the mother and the neonate. In order to determine the frequency of malnutrition and their relationship with complications in pregnant women and their newborns who go to the Capiata District Hospital of the Ministry of Public Health and Social Welfare, in the month of February to August 2022, a Descriptive observational study of retrospective cross -section that included 140 pregnant women, of which 64 presented complications for malnutrition and 76 did not present any complication. The Middle Ages was 26.9 ± 6.6 years with an age range of 15 to 40 years. The results show that 45.7% (n = 64) of pregnant women presented complications for malnutrition, 51.6% presented gestational diabetes, anemia in 29.7%, 7.8% presented anemia and gestational diabetes, the other 7.8% arterial hypertension, 1.6% expressed arterial hypertension and gestational diabetes and the other 1.6% presented anemia, arterial hypertension and gestational diabetes. In relation to nutritional evaluation at the beginning and at the end of pregnancy in pregnant women with complications there was a slight decrease in obesity percentages of 43.7% to 37.5% and an increase in low weight of 11% to 20, 3%. As for the type of childbirth in pregnant women with complications, 51.6%was due to caesarean section (n = 33), which presented gestational diabetes in 54.5%, followed by anemia in 21.2%. A higher percentage of overweight and obesity (29.7%) was proven in mother's newborns with complications. The frequency of malnutrition and complications could be evidenced in almost half of the pregnant women, it is necessary to generate greater public health strategies to prevent malnutrition and complications in pregnant women.

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Depression is considered the most important disorder affecting mental health. The aim of this systematic integrative review was: (i) to describe the effects of supplementation with adaptogens on variables related to depression in adults; and (ii) to discuss the potential combination with physical exercise to aid planning and commissioning future clinical research. An integrative review was developed complementing the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement (PROSPERO registration: CRD42021249682). A total of 41 articles met the inclusion criteria. With a Price index of 46.4%, we found that: (i) Hypericum perforatum (St. John's Wort) is the most studied and supported adaptogen (17/41 [41.46%], three systematic reviews with meta-analysis) followed by Crocus sativus L. or saffron (6/41 [14.63%], three systematic reviews with meta-analysis and two systematic reviews); (ii) it is possible that the significantly better performance of adaptogens over placebo is due to the reduction of allostatic load via the action of secondary metabolites on BDNF regulation; and, (iii) the number of studies reporting physical activity levels is limited or null for those that combine an exercise program with the consumption of adaptogens. Aware of the need for a multidisciplinary approach for depression treatment, this systematic integrative review provides an up-to-date view for supporting the use of St. John's Wort and saffron as non-pharmacological strategies while also help commissioning future research on the efficacy of other adaptogens. It also contributes to the design of future clinical research studies that evaluate the consumption of herbal extracts plus physical exercise, mainly resistance training, as a potentially safe and powerful strategy to treat depression.

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BACKGROUND: The identification of gastric polyps incidentally in endoscopies of the upper digestive tract has increased its incidence, varying between 0.5% and 23%. 10% of these polyps have symptoms, 40% are hyperplastic. We allow ourselves to propose a laparoscopic technique for the management of giant hyperplastic polyps associated with a pyloric syndrome, not susceptible to endoscopic resection. METHOD: A series of patients approached by laparoscopic transgastric polypectomy due to the giant gastric polyps associated with pyloric syndrome, in Bogotá, Colombia, from January 2015 to December 2018. RESULTS: Seven patients, 85% female, with an average age of 51 years, who were admitted for pyloric syndrome and were taken to laparoscopic management, with an average surgical time of 42 min, intraoperative bleeding 7-8 cc, tolerance to the oral route 24 hours, no conversion, without mortality. CONCLUSIONS: Transgastric polypectomy for the management of benign giant gastric polyps that cannot be resected endoscopically turns out to be a feasible method, with a low rate of complications and without mortality.

ANTECEDENTES: La identificación de pólipos gástricos de manera incidental en endoscopias de vías digestivas altas ha aumentado su incidencia, que varía entre el 0.5% y el 23%. El 10% de estos pólipos presentan síntomas y el 40% son hiperplásicos. Nos permitimos proponer una técnica laparoscópica para el manejo de los pólipos hiperplásicos gigantes asociados a síndrome pilórico no susceptibles de resección endoscópica. MÉTODO: Serie de pacientes llevados a polipectomía transgástrica laparoscópica por hallazgo de pólipos gástricos gigantes asociados a síndrome pilórico, en Bogotá, Colombia, de enero de 2015 a diciembre de 2018. RESULTADOS: Un total de siete pacientes, el 85% de sexo femenino, con edad promedio de 51 años, ingresaron por síndrome pilórico y fueron llevados a manejo laparoscópico, con un tiempo quirúrgico promedio de 42 minutos, sangrado intraoperatorio de 7-8 cc, tolerancia a la vía oral a las 24 horas, no conversión, sin mortalidad. CONCLUSIONES: La polipectomía transgástrica para el manejo de pólipos gástricos gigantes benignos que no pueden ser resecados por vía endoscópica resulta ser un método factible, con una baja tasa de complicaciones y sin mortalidad.

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The antimicrobial activity and biological efficiency of silver nanoparticles (AgNps) have been widely described and can be modeled through stabilizing and reducing agents, especially if they exhibit biocidal properties, which can enhance bioactivity against pathogens. The selective action of AgNps remains a major concern. In this regard, the use of plant extracts for the green synthesis of nanoparticles offers advantages because it improves the toxicity of Nps for microorganisms and is harmless to normal cells. However, biological evaluations of the activity of AgNps synthesized using different reducing agents are determined independently, and comparisons are frequently overlooked. Thus, we investigated and compared the antifungal and cytotoxic effects of two ecological AgNps synthesized from Moringa oleifera aqueous leaf extract (AgNp-M) and glucose (AgNp-G) against azole-resistant clinical isolates of Candida spp. and nontumor mammalian cells. Synthesized AgNps exhibited an antifungal effect on planktonic cells of drug-resistant C. albicans and C. tropicalis (MIC 0.21-52.6 µg/mL). The toxicity was influenced by size. However, the use of M. oleifera extracts allows us to obtain AgNps that are highly selective and nongenotoxic to Vero cells due to modifications of the shape and surface. Therefore, these results suggest that AgNp-M has antimicrobial potential and deserves further investigation for biomedical applications.

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ABSTRACT Aedes albopictus is considered a potential vector of arboviruses in Colombia. Females and males naturally infected with dengue, Zika and chikungunya viruses have already been found in this country. We document the first record of Ae. albopictus in the Cordoba department, in North of Colombia. The finding was carried out during Ae. aegypti collection activities in the Ayapel, Montelibano, Planeta Rica, Pueblo Nuevo and Puerto Libertador municipalities. The entomological material was collected in water containers such as cement water tanks, tanks, bottles, tires, abandoned toilets, and plastic lids with natural water located in the intradomicile, peridomicile, and extra-domicile spaces of the homes. We collected 658 Ae. albopictus samples in the larva and pupa stages, and once these reached adulthood, we determined that 389 were female and 269 were male. This is the first record of the presence of Ae. albopictus in the Cordoba department.

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Introduction: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation, causing pain and stiffness in the joints. SARS-CoV-2 increases the clinical vulnerability of the population with RA and has led to the implementation and/or development of telemedicine. Objective: To describe changes in level of therapeutic adherence, quality of life and capacity for self-care agency, during the follow-up period of a group of patients linked to a non-face-to-face multidisciplinary consultation model during the SARS-CoV-2 pandemic. Methodology: Descriptive cohort study (July to October 2020). Description of the level of therapeutic adherence (Morisky Green Test), quality of life (EuroQOL-5-Dimensions-3-Level-version) and self-care capacity (ASA-R Scale) in the context of a telehealth model. A univariate and bivariate analysis was performed (Stata Software, Considered p-value <0.05). Results: Of 71 patients treated under the telehealth model, 85.9% were women, the age range was between 33 and 86 years with a median of 63. The most prevalent comorbidity was arterial hypertension (35.2%). Quality of life did not change during follow-up nor did adherence to treatment, apart from in one item [the patients did not stop taking the medication when they were well (p = 0.029)]. In self-care capacity, there were significant improvements in five dimensions (p < 0.05), without significant differences in the global score. Conclusion: Patients with RA evaluated in the context of telehealth in a period of pandemic did not present significant changes in quality of life, adherence to treatment, or capacity for self-care, and remained close to baseline values when they attended a traditional face-to-face assessment.

INTRODUCCIÓN: La artritis reumatoide (AR) es una enfermedad autoinmune caracterizada por una inflamación crónica que produce dolor y rigidez articular. El SARS-CoV-2 aumenta la vulnerabilidad clínica en pacientes con AR, lo que ha conllevado la implementación o el desarrollo de la telesalud. OBJETIVO: Describir los cambios en el nivel de adherencia terapéutica, la calidad de vida y la capacidad de autocuidado durante el periodo de seguimiento, en un grupo de pacientes con AR vinculados con un modelo de consulta multidisciplinar no presencial, en el curso de la pandemia por SARS-CoV-2. METODOLOGÍA: Estudio de cohorte descriptiva (julio a octubre del 2020). Descripción del nivel de adherencia terapéutica (TEST MORISKY GREEN), calidad de vida (EUROQOL-5-DIMENSIONS-3-LEVEL-VERSION) y capacidad de autocuidado (Escala ASA-R) en el contexto de un modelo de telesalud. Se realizó análisis univariado y bivariado (SOFTWARE Stata®, valor de p considerado <0,05). RESULTADOS: De 71 pacientes atendidos en modalidad de telesalud, el 85,9% fueron mujeres, la mediana de la edad fue de 63 (33-86) anos. La comorbilidad más prevalente fue la hipertensión (35,2%). La calidad de vida no tuvo cambios durante el seguimiento, al igual que la adherencia al tratamiento, excepto en uno de los ítems (los pacientes no dejaron de tomar la medicación cuando se encontraban bien; p = 0,029). En la capacidad de autocuidado hubo mejoras significativas en 5 dimensiones (p < 0,05), sin diferencias significativas en el puntaje global. CONCLUSIÓN: Los pacientes con AR evaluados en el contexto de la telesalud, en un periodo de pandemia, no presentaron cambios significativos en la calidad de vida, la adherencia al tratamiento y la capacidad de autocuidado; se mantuvieron en niveles similares a los valores basales cuando asistían a valoración tradicional presencial.

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In Argentina, the human T-cell lymphotropic virus type 1 (HTLV-1) infection has been documented mainly among blood banks with a prevalence of ~0.02-0.046% for Buenos Aires city, 0.8% for the northeast, and 1% for the northwest; both areas are considered endemic for HTLV-2 and 1, respectively. Policies and specific guidelines for testing blood donors for HTLV are included since 2005. Screening for antibodies is performed at blood banks and confirmatory testing is performed at reference laboratories. There are no specific recommendations for the assistance of communities and individuals affected, nor referral to specialized clinics on the HTLV infection. In 2016, as a strategy of intervention, we opened a specialized clinical attendance in a referral infectious diseases public hospital for the comprehensive approach to patients with HTLV, offering follow-up and counseling for patients and their families for the early diagnosis of HTLV-1/2 and related diseases. During the study, 124 patients with presumptive HTLV positive diagnosis from blood bank, symptomatic patients (SPs), relatives, and descendants visited the unit. A total of 46 patients were HTLV positive (38 HTLV-1 and 8 HTLV-2). There were nine SPs (2 adult T-cell leukemia/lymphoma [ATL] and 7 HTLV-1-associated myelopathy/tropical spastic paraparesis [HAM/TSP]). All patients with HTLV-1 and-2 were offered to study their relatives. Two out of 37 (5.4%) descendants tested were positive for HTLV-1. Sexual partners were studied; among 6 out of 11 couples (54.5%) were found positive (5 HTLV-1 and 1 HTLV-2). Other relatives, such as mothers (1/2) and siblings (1/6), were positive for HTLV-1. According to the place of birth among HTLV-1 carriers, 58% were born in an endemic area or in countries where HTLV infection is considered endemic while for HTLV-2 carriers, 12.5% were born in an endemic area of Argentina. The proviral load (pVL) was measured in all, patients with HTLV-1 being higher in symptomatic compared with asymptomatic carriers. In addition, two pregnant women were early diagnosed during their puerperium and breastmilk replacement by formula was indicated. Inhibition of lactation was also indicated. Our study provides tools for a multidisciplinary approach to the infection and reinforces the importance of having specialized clinical units in neglected diseases, such as HTLV for counseling, clinical and laboratory follow-up, and providing useful information for patients for self-care and that of their families.

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