RESUMO

Cisplatin is a chemotherapy agent known for its neurotoxicity. We evaluated the effect of cisplatin on the gastric emptying (GE), gastrointestinal (GI) transit of liquid, baroreflex function, thermal, and mechanical withdrawal latencies in rats. Cisplatin increased the GE of liquid with doses ≥ 2 mg.kg(-1) by 59.7-77.4%. This GE delay was not present two weeks after the treatment with five doses of cisplatin at 1 mg.kg(-1). Cisplatin also enhanced baroreflex gain possibly by increasing sympathetic activity. Our results demonstrated that cisplatin (2-10 mg.kg(-1)) causes autonomic neuropathy with GI and baroreflex changes and mechanical but not thermal hyperalgesia in rats.

Assuntos

Antineoplásicos/toxicidade , Barorreflexo/efeitos dos fármacos , Cisplatino/toxicidade , Motilidade Gastrointestinal/efeitos dos fármacos , Hiperalgesia/induzido quimicamente , Animais , Relação Dose-Resposta a Droga , Esvaziamento Gástrico/efeitos dos fármacos , Trânsito Gastrointestinal/efeitos dos fármacos , Masculino , Ratos , Ratos Wistar , Tempo de Reação/efeitos dos fármacos