RESUMO
Presence of human immunodeficiency virus (HIV) within noninflamed human dental pulps was documented by polymerase chain reaction assays in 11 of 12 pulps from HIV-seropositive patients. The purpose of the present study was to determine the cellular location of HIV in vivo within these tissues by means of in situ hybridization. Results of the in situ hybridization indicated HIV within fibroblasts of the pulp. These results are especially relevant because fibroblasts lack the CD4 receptor thought necessary for in vivo infection with HIV. These results suggest the fibroblast as a possible reservoir for HIV in the body.
Assuntos
Polpa Dentária/microbiologia , Soropositividade para HIV/microbiologia , HIV/isolamento & purificação , Linfócitos T CD4-Positivos , DNA Viral/análise , Fibroblastos/microbiologia , Humanos , Hibridização de Ácido Nucleico , Reação em Cadeia da Polimerase , RNA Mensageiro/análiseRESUMO
Human immunodeficiency virus-associated gingivitis (HIV-G) has been described recently as a clinical entity in HIV-infected patients. However, little is known about the etiology and pathogenesis of this condition. We report a case of HIV-G in a 32-year-old man with acquired immunodeficiency syndrome (AIDS). The histology of the clinically involved gingiva revealed the absence of an inflammatory cell infiltrate. This report provides an initial description of the histologic changes occurring in HIV-G.