RESUMO
Behavioral disorders affect most diabetic patients and Zinc (Zn) has been used among adjuvant therapies for involvement in the etiology of depression and anxiety, however, the results are still controversial. The objective of this study was to compare the antidepressant, anxiolytic and neuroprotective activity of the supplementation of two Zn compounds in an animal model of Diabetes Mellitus type 1 (DM1). Thirty-eight (38) adult rats were randomized into four groups: Control (C; n = 8); Diabetic (D; n = 10); Diabetic Zn Sulfate Supplement (DSZ; n = 10) and Diabetic Zn Gluconate Supplement (DGZ; n = 10). The DSZ group received Zn sulfate supplementation and the DGZ group received Zn gluconate supplementation at a dose of 15 mg/kg for 4 weeks. Data (mean ±SEM) were analyzed by the Mann-Whitney test with a significance level of p < 0.05. The results indicate that Zn gluconate supplementation in diabetic animals presented an antidepressant effect demonstrated through the results obtained in the Forced Swim Test, and neuroprotective effect by attenuating alterations in the cerebral cortex; while Zn sulfate supplementation in diabetic animals showed an anxiolytic effect demonstrated by the results obtained in the open field test and the elevated plus maze test. Considering the set of results, supplementation with both zinc compounds showed neurobehavioral benefits in diabetic animals with different effects depending on the type of anion associated with Zn.
RESUMO
Objetivo: Avaliar a relação entre os valores de leucócitos e proteína C- reativa ultrassensível (PCR-us) e o consumo alimentar habitual de vitaminas com ação antioxidante em idosos, considerando-se a inexistência de estudos. Material e Métodos: Adotou-se delineamento epidemiológico transversal, utilizando-se amostragem de uma população idosa, envolvendo 174 indivíduos com idade igual ou superior a 60 anos, de diferentes condições socioeconômicas e de saúde, como obesidade, hipertensão e diabetes. Resultados: Para verificar a correlação entre as variáveis, utilizou-se o coeficiente de correlação de Spearman. Houve correlação negativa entre os valores de leucócito e vitamina E (r = -0,29, p = 0,0316), ß-caroteno (r = -0,32, p = 0,0189), leucócito e vitamina A (r = -0,36, p= 0,0062), e correlação entre os valores de leucócito e vitamina C, como também entre PCR-us e o consumo alimentar habitual dessas vitaminas. Conclusão: Com base nas correlações encontradas entre os valores de leucócitos e as vitaminas mencionadas, a ingestão dessas vitaminas, seria ainda mais justificada, considerando-se também, a sua importância na adequação dos valores de leucócitos. (AU)
Objective: To evaluate the relationship between leukocyte counts and ultra-sensitive C-reactive protein (hs-CRP) and the usual dietary intake of vitamins with antioxidant action in the elderly. Material and Methods: This was a cross-sectional epidemiological study with a sample of 174 individuals aged 60 years and over, from different socioeconomic and health conditions, such as obesity, hypertension and diabetes. Results: To verify the correlation among the study variables, the Spearman correlation coefficient was utilized. There was a negative correlation between leukocyte counts and the intake of vitamin E (r = -0.29, p = 0.0316), ß -carotene (r = -0.32, p = 0.0189), as well as vitamin A (r = - 0.36, p = 0.0062). On the other hand, there was a correlation between leukocyte counts and the intake of vitamin C as well as between the hs-CRP and the usual intake of these vitamins. Conclusion: Based on the correlations found, the intake of these vitamins would be more justified considering their importance in the adaptability of leukocyte counts. (AU)