RESUMO
Aeromonas caviae strains have been isolated from blood and stool cultures of three immunocompetent patients, residents of Northern India, who presented with community acquired septicemia without any recent history of diarrhea. Cell culture infectivity test performed on Hep-2 cells have shown substantial degree of invasiveness in the isolated strains. This case unleashes a possibility of asymptomatic gastrointestinal carriage of such strains of A. caviae in a very large population of India, as several areas of India have very high rates of Aeromonas induced acute diarrhea/gastroenteritis (up to 13 percent). It needs to be appraised further in India as well as other countries having high rates of Aeromonas induced acute diarrhea/gastroenteritis.
Assuntos
Humanos , Aeromonas/isolamento & purificação , Bacteriemia/microbiologia , Sistema Digestório/microbiologia , Infecções por Bactérias Gram-Negativas/microbiologia , Aeromonas/classificação , Amicacina/uso terapêutico , Antibacterianos/uso terapêutico , Bacteriemia/diagnóstico , Bacteriemia/tratamento farmacológico , Portador Sadio , Infecções Comunitárias Adquiridas/diagnóstico , Infecções Comunitárias Adquiridas/tratamento farmacológico , Infecções Comunitárias Adquiridas/microbiologia , Fezes/microbiologia , Infecções por Bactérias Gram-Negativas/diagnóstico , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Imunocompetência , ÍndiaRESUMO
Aeromonas caviae strains have been isolated from blood and stool cultures of three immunocompetent patients, residents of Northern India, who presented with community acquired septicemia without any recent history of diarrhea. Cell culture infectivity test performed on Hep-2 cells have shown substantial degree of invasiveness in the isolated strains. This case unleashes a possibility of asymptomatic gastrointestinal carriage of such strains of A. caviae in a very large population of India, as several areas of India have very high rates of Aeromonas induced acute diarrhea/gastroenteritis (up to 13%). It needs to be appraised further in India as well as other countries having high rates of Aeromonas induced acute diarrhea/gastroenteritis.
Assuntos
Aeromonas/isolamento & purificação , Bacteriemia/microbiologia , Sistema Digestório/microbiologia , Infecções por Bactérias Gram-Negativas/microbiologia , Aeromonas/classificação , Amicacina/uso terapêutico , Antibacterianos/uso terapêutico , Bacteriemia/diagnóstico , Bacteriemia/tratamento farmacológico , Portador Sadio , Infecções Comunitárias Adquiridas/diagnóstico , Infecções Comunitárias Adquiridas/tratamento farmacológico , Infecções Comunitárias Adquiridas/microbiologia , Fezes/microbiologia , Infecções por Bactérias Gram-Negativas/diagnóstico , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Humanos , Imunocompetência , ÍndiaRESUMO
The authors reported an increased in the cerebrospinal fluid concentration of glutamine in seven paranoid schizophrenic patients. They found no changes in the levels of the remaining 20 free amino acids assayed.
Assuntos
Glutamina/líquido cefalorraquidiano , Esquizofrenia Paranoide/líquido cefalorraquidiano , Adulto , Aminoácidos/líquido cefalorraquidiano , Antipsicóticos/uso terapêutico , Serviços Médicos de Emergência , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Esquizofrenia Paranoide/tratamento farmacológicoRESUMO
The infection with the Venezuelan equine encephalomyelitis virus produced a significant increase in the concentration of alanine, arginine, asparagine, glutamine, isoleucine, leucine, methionine, phenylalanine, threonine, tryptophan, tyrosine, and valine in the striatum of rats. On the contrary, the concentrations of aspartate, GABA, glutamate, and taurine were reduced. Arginine, aspartate, glycine, methionine, phenylalanine, taurine, and tyrosine concentrations were increased in the serum of infected rats. However, the modifications in the content of free amino acids in the striatum and serum of rats that survived the infection were qualitatively and quantitatively different from those detected during the acute phase of the infection.
Assuntos
Aminoácidos/análise , Corpo Estriado/análise , Encefalomielite Equina/sangue , Encefalomielite Equina Venezuelana/sangue , Aminoácidos/sangue , Animais , Encefalomielite Equina Venezuelana/metabolismo , Ratos , Ratos EndogâmicosRESUMO
We studied the levels of free amino acids in putamen and Brodmann's area 10 of 12 patients who died with Huntington's disease and 13 non-neurologic controls. GABA, glutamate and alpha-amino-n-butyric acid concentrations were found to be reduced in putamen of Huntington's disease patients. In Brodmann's area 10 the levels of glutamate, histidine and lysine were decreased, but the content of aspartate, GABA, glycine, serine and taurine was increased in the same group of patients.
Assuntos
Aminoácidos/metabolismo , Encéfalo/metabolismo , Doença de Huntington/metabolismo , Adulto , Idoso , Idoso de 80 Anos ou mais , Ácido Aspártico/metabolismo , Feminino , Glutamatos/metabolismo , Ácido Glutâmico , Glicina/metabolismo , Histidina/metabolismo , Humanos , Lisina/metabolismo , Masculino , Pessoa de Meia-Idade , Putamen/metabolismo , Serina/metabolismo , Taurina/metabolismo , Ácido gama-Aminobutírico/metabolismoRESUMO
In mice inoculated with the Guajira strain of Venezuelan equine encephalomyelitis virus, a significant increase in the concentration of arginine, isoleucine, leucine, glycine, phenylalanine, serine, threonine, and valine was produced in the striatum. On the contrary, the levels of alanine, asparagine, aspartate, GABA, glutamine, and taurine were reduced. No changes were observed in the striatal content of tyrosine and glutamic acid.