RESUMO
RESUMEN: Introducción: Actualmente no hay consenso sobre el manejo anestésico más adecuado en el implante valvular aórtico percutáneo por vía transfemoral. Aunque se ha demostrado la factibilidad de concretar el procedimiento bajo anestesia local con sedación consciente o sin esta, los resultados clínicos reportados son controvertidos. Objetivos: Evaluar la seguridad y eficacia del implante valvular aórtico percutáneo por vía transfemoral realizado bajo anestesia general versus anestesia local con sedación consciente. Material y métodos: Análisis unicéntrico y retrospectivo de los pacientes con estenosis aórtica grave sintomática con alto riesgo quirúrgico sometidos a un implante valvular aórtico percutáneo por vía transfemoral desde marzo de 2009 a diciembre de 2016, según el manejo anestésico. Los desenlaces de seguridad y eficacia fueron evaluados a 30 días según las definiciones del Valve Academic Research Consortium-2. Además, se evaluaron los principales tiempos durante la internación. Resultados: Se incluyeron 121 pacientes (Edad 83,2 ± 5,7 años, hombres 48,8%), tratados con un implante valvular aórtico percutáneo por vía transfemoral bajo anestesia general (n = 55, 45,5%) o anestesia local con sedación consciente (n = 66, 54,5%). No se observaron diferencias significativas en los resultados intraprocedimiento ni en los desenlaces de seguridad y eficacia a 30 días. La mortalidad a 30 días fue del 7,3% en el grupo AG y del 3% en el grupo anestesia local con sedación consciente 3%, p log-rank 0,28 (mortalidad global 5%). La necesidad de conversión a anestesia general se presentó en 2 pacientes (3%), por complicaciones vasculares mayores durante el procedimiento. El grupo anestesia local con sedación consciente presentó menor tiempo total de procedimiento, internación en unidad de cuidados intensivos e internación total. Conclusión: El implante valvular aórtico percutáneo por vía transfemoral realizado bajo anestesia local con sedación consciente, parece ser una alternativa segura y eficaz al uso de anestesia general.
Abstract: Background: Currently, there is no consensus about the most adequate anesthetic management in transfemoral transcatheter aortic valve replacement. Although it has been shown that local anesthesia (LA) with or without conscious sedation is feasible, clinical results are controversial. Objective: The aim of this study was to evaluate the safety and efficacy of transfemoral transcatheter aortic valve replacement performed under general anesthesia versus local anesthesia with conscious sedation. Methods: This was a single-center, retrospective study of high risk patients with severe aortic stenosis undergoing transfemoral transcatheter aortic valve replacement between March 2009 and December 2016. The population was divided according to anesthetic management. Safety and efficacy outcomes were evaluated at 30-days and were classified according to definitions of the Valve Academic Research Consortium-2. In addition, key times during hospitalization were evaluated. Results: A total of 121 patients undergoing transfemoral transcatheter aortic valve replacement under general anesthesia (n=55, 45.5%) or local anesthesia with conscious sedation (n=66, 54.5%). were included in this analysis. Mean age was 83.2±5.7 years and 48.8% were men. There were no differences in either the procedural result or in the 30-day efficacy and safety outcomes. The rate of death at 30-days was 7.3% in the group with general anesthesia and 3% in the local anesthesia with conscious sedation group (log-rank p 0.28). The need of conversion to general anesthesia was 3% (2 patients), in all cases due to major vascular complications during the procedure. In the local anesthesia with conscious sedation group shorter procedural time, intensive care unit and hospital length of stay were observed. Conclusions: Transfemoral transcatheter aortic valve replacement performed under local anesthesia with conscious sedation seems to be a safe and effective alternative to the use of general anesthesia.
Assuntos
Masculino , Feminino , Adulto , Humanos , Padrões de Prática Médica/normas , Ecocardiografia/métodos , EcocardiografiaRESUMO
OBJECTIVE: The purpose of this study was to analyze the predictive value of different anatomic echocardiographic findings for diagnosis of prosthetic endocarditis. BACKGROUND: Prognosis in endocarditis has improved in recent years after the wide acceptance of new clinical diagnostic criteria. One of the most important issues in clinical diagnosis is to use echocardiography for identification of endocardial involvement, but prosthetic material impairs echo quality. METHODS: In all, 49 patients with 58 episodes of suggested prosthetic endocarditis were prospectively studied using transthoracic and transesophageal echocardiography. The patients were divided into two groups: group A, patients with 34 episodes of definite endocarditis according to Durack's criteria; and group B, patients with 24 episodes who were eventually classified as not having endocarditis, either by surgical exploration or by a mean of 32.6 months (range: 8-38 months) of follow-up. RESULTS: In group A, valve dehiscence was observed in 4 episodes of suggested endocarditis, pseudoaneurysms in 3, fistulae in 2, and moderate to severe perivalvular regurgitation in 15. No patient in group B had these abnormalities (P <.001). Vegetations were present in 17 episodes in group A (50%) versus 1 in group B (9%; P <.001); perivalvular abscesses were seen in 19 episodes in group A (56%) versus 1 in group B (P <.001). Mild perivalvular regurgitation was observed in only 1 episode for group A (3%) and in 14 episodes for group B (58%; P <.01). The presence of any of the above echocardiographic finding, when used in combination with the exclusion of mild perivalvular regurgitation, had a positive and negative predictive value for diagnosing endocarditis of 94% and 96%, respectively. Isolated mild perivalvular regurgitation had a poor positive predictive value (6%). CONCLUSION: Isolated mild perivalvular regurgitation should not be used as diagnostic criteria in patients with suggested prosthetic valve endocarditis.