RESUMO
This study was aimed at investigating the anti-osteoporotic effects of the extract of Ginkgo biloba (EGb) in glucocorticoid-induced-osteoporosis. A significant reduction was observed in the percentage of the bone of the osteoporosis group in both the mandible and femur. The EGb group treated with 28 and 56 mg/Kg showed a significant increase in the percentage of trabecular bone (PTB) of the femur. The percentage of the alveolar bone of the mandible (PAB) had a significant increase with all doses of EGb. The treatment with EGb significantly reversed the loss of the PAB of the mandible and of the PTB of the femur.
Assuntos
Densidade Óssea/efeitos dos fármacos , Ginkgo biloba/química , Osteoporose/tratamento farmacológico , Fitoterapia , Extratos Vegetais/farmacologia , Animais , Dexametasona/análogos & derivados , Dexametasona/toxicidade , Feminino , Fêmur , Mandíbula , Osteoporose/induzido quimicamente , Extratos Vegetais/química , Distribuição Aleatória , Ratos , Ratos WistarRESUMO
The interceptive effect of the powder of Solanum lycocarpum (St. Hil) (Solanaceae) fruit, used as a hypoglycemic agent by diabetic patients in Minas Gerais state (Brazil), was evaluated to observe possible effects upon zygote and pre-embryo transport in rats, since it contains solamargine and solasonine from which a 3beta-acetoxipregna-5,16-dien-20-one is obtained as well as an alkaloid with stereospecific configuration to the synthesis of steroid hormones. Inseminated rats received an aqueous suspension of 100 mg of the lobeira powder/kg of body weight, by oral gavage, from the 1st to the 4th day of pregnancy. A control group received 5 mL of distilled water in the same schedule. The pregnant rats were weighed at the beginning of treatment and on sacrifice day. Animals were killed on the 5th day of pregnancy. The oviducts and uterine horns were removed and flushed with saline solution to count expanded blastocysts. It was concluded that administration of lobeira did not cause maternal toxicity, alteration of the pre-embryo transport or reduction of the number of expanded blastocysts.
Assuntos
Blastocisto/efeitos dos fármacos , Hipoglicemiantes/toxicidade , Solanaceae/química , Animais , Feminino , Gravidez , Ratos , Ratos Wistar , Alcaloides de Solanáceas/toxicidade , Fatores de TempoRESUMO
Powdered Solanum lycocarpum fruit is commonly used to treat diabetes, but apparently no studies have been conducted to evaluate potential adverse side effects. In the present paper the toxic effect of S. lycocarpum was evaluated in adult male Wistar rats and Swiss mice. The administration of an aqueous extract prepared using a powder obtained from the S. lycocarpum fruit at two different dose levels (60 mg/15 ml and 120 mg/15 ml distilled water for rats and 30 mg/15 ml and 60 mg/15 ml distilled water for mice, twice daily for 5 days in each case) did not produce body weight variations in either species although a significant weight change was observed in some organs. Significant weight loss was observed only in the ventral prostate of mice receiving the high dose treatment. These results suggest a toxic effect of S. lycocarpum on the male reproductive system of the Swiss mouse, with possible antiandrogenic activity, but there was no apparent antifertility activity in rats at the doses given.
Assuntos
Genitália Masculina/efeitos dos fármacos , Extratos Vegetais/toxicidade , Alcaloides de Solanáceas/toxicidade , Administração Oral , Animais , Relação Dose-Resposta a Droga , Masculino , Camundongos , Tamanho do Órgão/efeitos dos fármacos , Ratos , Ratos WistarRESUMO
Os autores fazem em ordem cronologica, exaustiva revisao da literatura das diferentes tecnicas de piloroplastia, desde a primeira descrita por Heineke e Mikulicz em 1886 e 1888. Definem piloroplastia como todo procedimento cirurgico sobre o piloro, englobando a pilorectomia e a piloromiotomia. Apresentaram ao todo 35 tecnicas operatorias