RESUMO
The goal of the present study was to propose a set of preliminary regional diagnostic reference levels (DRLs) for pediatric interventional cardiology (IC) procedures in Latin America and the Caribbean countries, classified by age and weight groups. The study was conducted in the framework of the Optimization of Protection in Pediatric Interventional Radiology in Latin America and the Caribbean program coordinated by the World Health Organization and the Pan American Health Organization in cooperation with the International Atomic Energy Agency. The first step of the program was focused on pediatric IC. Dose data from diagnostic and therapeutic procedures were collected between December 2020 and December 2021. Regional DRLs were set as the third quartile of patient dose data (kerma area product) collected in 18 hospitals from 10 countries in an initial sample of 968 procedures. DRLs were set for four age bands and five weight ranges. The values obtained for the four age bands (<1 yr, 1 to <5 yr, 5 to <10 yr and 10 to <16 yr) were 2.9, 6.1, 8.8 and 14.4 Gy cm2for diagnostic procedures, and 4.0, 5.0, 10.0 and 38.1 Gy cm2for therapeutic procedures, respectively. The values obtained for the five weight bands (<5 kg, 5 to <15 kg, 15 to <30 kg, 30 to <50 kg and 50 to <80 kg) were 3.0, 4.5, 8.1, 9.2 and 26.8 Gy cm2for diagnostic procedures and 3.7, 4,3, 7.3, 16.1 and 53.4 Gy cm2for therapeutic procedures, respectively. While initial data were collected manually as patient dose management systems (DMSs) were not available in most of the hospitals involved in the program, a centralized automatic DMS for the collection and management of patient dose indicators has now been introduced and is envisaged to increase the sample size. The possibility of alerting on high dose values and introducing corrective actions will help in optimization.
Assuntos
Cardiologia , Níveis de Referência de Diagnóstico , Cardiologia/métodos , Criança , Fluoroscopia , Humanos , América Latina , Doses de Radiação , Radiografia Intervencionista/métodos , Radiologia Intervencionista , Valores de ReferênciaRESUMO
Hydrocolloids are used as stabilizing agents in order to enhance the physical stability of emulsions during their storage. However, they can also play an important role in nutrient release and bioavailability. In this context, the aim of this research was to study the effect of the emulsion type and thickener type on the physical-structural changes and free fatty acid release during in vitro digestion. Oil-in-water emulsions were prepared with different particle sizes (CE: conventional emulsions and NE: nanoemulsions) and thickening agents (starch and xanthan gum). The experimental conditions of homogenization used allowed food emulsions to be obtained at the microscale and nanoscale, with particle sizes ranging among 3.2-3.4 µm and 78-107 nm for CE and NE, respectively. The addition of thickening agents (XG and ST) modified the physical properties of emulsions (particle size, zeta potential and stability) slightly, and thickened samples with similar viscosity were obtained. The kinetics of FFAs released during the in vitro intestinal digestion showed no significant differences (p > 0.05) in the digestion rate among samples; however, emulsion and thickener types decreased the final extent of free fatty acids, being more evident for those samples with starch. Xanthan gum kept the particle size of nanoemulsions stable during the oral and gastric phases, which promoted the release of FFAs during the intestinal phase. Therefore, xanthan gum could be used as a thickening agent of nanoemulsions exerting a minor impact on their lipid bioaccessibility.
Assuntos
Emulsões/química , Ácidos Graxos não Esterificados , Tamanho da Partícula , Polissacarídeos Bacterianos , Amido , Viscosidade , Água , Idoso , Envelhecimento , Disponibilidade Biológica , Coloides , Transtornos de Deglutição , Gorduras na Dieta/análise , Digestão , Ácidos Graxos não Esterificados/análise , Alimento Funcional , Humanos , Cinética , Metabolismo dos Lipídeos , Lipídeos , Nanoestruturas , Persea , Óleos de Plantas/químicaRESUMO
The aim of this work was to analyse the radiation dose for patients and staff between X-ray systems, a new biplane with flat-panel detectors (FDs) and a conventional system equipped with image intensifier (II). Entrance surface air kerma (ESAK) and scatter doses were measured on polymethyl methacrylate (PMMA) phantoms of different thicknesses (from 4 to 16 cm). The ESAK values for the different acquisition modes and PMMA thicknesses were higher for the II in comparison with FDs. For the II, the scatter dose rates ranged from 0.67 to 12.2 mSv h(-1) at the eye position of the cardiologist during fluoroscopy and cine modes. At the lower extremities, these values were 1.11 and 24.24 mSv h(-1). In the case of the FDs, these values ranged from 0.24 to 0.67 mSv h(-1) for eye lens and from 0.73 to 2.01 mSv h(-1) for the position of cardiologist's ankle. The newly installed X-ray system showed an average reduction factor of up to 9.7 times for ESAK values. For the staff with an average reduction factor of 15.9 times at the eye position during fluoroscopy and cine modes, no protective tools are used. At the lower extremities, this value was 7.6 times.
Assuntos
Angiografia/instrumentação , Cardiologia/instrumentação , Radiologia Intervencionista/instrumentação , Ar , Angiografia/métodos , Cardiologia/métodos , Desenho de Equipamento , Fluoroscopia/instrumentação , Fluoroscopia/métodos , Humanos , Pediatria/instrumentação , Pediatria/métodos , Imagens de Fantasmas , Polimetil Metacrilato/química , Doses de Radiação , Proteção Radiológica/métodos , Intensificação de Imagem Radiográfica/instrumentação , Radiologia Intervencionista/métodos , Espalhamento de Radiação , Raios XRESUMO
The aim of this study was to evaluate the occurrence of the Maillard reaction on gelatin-based films (bovine and salmon) in the glassy state, in mixtures with low molecular weight plasticizers (e.g. glycerol, glucose and trehalose) at different storage times. For testing, the gelatin-plasticizer films were stored under glassy conditions (Tg-10°C), previously determined by calorimetric tests. Studies under accelerated conditions (T â« Tg) were also developed. Color, opacity and browning index (Br) were evaluated by computer vision at all storage times. Results showed in samples stored under glassy conditions that the Maillard reaction did not occur, independent of gelatin origin and type of plasticizer. Changes in color stated by opacity and Br were only significant (p < 0.05) in gelatin-glucose systems under accelerated storage conditions. The inhibition of reaction in gelatin films in the glassy state was related to the well-known conditions of low molecular mobility of glassy matrices, but also with the non-Maillard reactive characteristics of glycerol and trehalose.
Assuntos
Gelatina/química , Plastificantes/química , Animais , Bovinos , Reação de Maillard , SalmãoRESUMO
El aumento del peso de los órganos puede ser signo de enfermedades o anormalidades patológicas. Diversos estudios han llevado a la elaboración de tablas con los pesos estándar de los diferentes órganos en diversos grupos poblacionales. Basados en esta premisa, determinamos el peso del hígado, bazo y riñones en dos grupos de individuos Chilenos, Mapuches (M) y No-Mapuches (n-M), de ambos sexos y relacionamos los resultados con la edad e índice de masa corporal (IMC). El peso promedio del hígado en el hombre, con relación a la edad, aumenta levemente (n-M) o disminuye en un pequeño porcentaje (M). Sin embargo, en la mujer (M) el peso aumentó en un 22,8% En relación al IMC, el peso promedio del hígado, aumenta en los hombres de ambos grupos étnicos en alrededor de un tercio del peso registrado en personas con IMC de 2025; en mujeres de ambos grupos el peso disminuye levemente. El peso del bazo, en relación a la edad, disminuye alrededor de un 4%, en hombres de ambos grupos étnicos y mujeres (n-M) a diferencia de las mujeres (M) que se incrementa en un 18%. En relación al IMC, el peso del bazo aumenta en los hombres de ambos grupos étnicos en alrededor de un 40%. Los riñones tienen un leve incremento en su peso promedio en ambos grupos. De acuerdo al IMC, el peso de los riñones aumenta en hombres de ambos grupos. En las mujeres (M) el peso se mantiene o disminuye levemente; en las mujeres (n-M) ambos riñones incrementan su peso. Los datos aportados en esta investigación servirán de referencia a la anatomía clínica y quirúrgica de los órganos abdominales de nuestra población.
The increase of organ weight may be a sign of disease or pathological abnormalities. Several studies have led to the development of tables with standard weights of different organs in various population groups. Based on this premise, we determined the weight of the liver, spleen and kidneys in two groups of Chilean individuals, Mapuche (M) and non-Mapuche (nM) of both sexes and related the results with age and body mass index (BMI). The average weight of the liver in man in relation to age, slightly increases (nM)) or decreases in small percentage (M). However, in women (M) its weight increased by 22.8% in relation to BMI, the average weight of the liver increases in males of both ethnic groups in about a third of the weight recorded in people with BMI 2025; in women of both groups the weight decreases slightly. Spleen weight in relation to age, decreases by about 4% in men and women from both ethnic (nM) groups, unlike that of Mapuche women (M) where weight increased by 18%. In relation to BMI, spleen weight increased in males of both ethnic groups by about 40%. The kidneys had a slight increase in average weight in both groups. According to BMI, the kidney weights increased in males of both groups. In women (M) the weight is maintained or decreased slightly; in women (nM) both kidneys increase their weight. The data provided in this study will serve as a reference for clinical and surgical anatomy of the abdominal organs of our population.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Tamanho do Órgão , Baço/anatomia & histologia , Índice de Massa Corporal , Rim/anatomia & histologia , Fígado/anatomia & histologia , Peso Corporal , Chile , Fatores Etários , Caracteres Sexuais , Grupos RaciaisRESUMO
Diversos factores pueden influir en el peso de las vísceras torácicas y/o abdominales. Con el propósito de conocer el peso promedio del corazón y pulmones de individuos chilenos, se obtuvo la información de estos órganos procedentes de 775 necropsias de cadáveres frescos, entre los años 2009-2013, considerando su procedencia étnica (Mapuches y no Mapuches), edad, sexo e índice de masa corporal. Se estudiaron los datos de órganos sin lesiones ni enfermedades aparentes. En relación a la edad, el peso promedio del corazón se incrementó en ambos grupos étnicos y ambos sexos. Este incremento fue similar en los individuos de sexo masculino de ambos grupos étnicos, con un valor de 13%. En los individuos de sexo femenino hubo un aumento de 36% en el grupo étnico Mapuche, mientras que en el grupo No-Mapuche fue de un 8%. Con respecto a los pulmones, no hubo incremento de su peso promedio en individuos masculinos del grupo Mapuche, pero si lo hubo en el sexo femenino, donde hubo un incremento sobre el 40% Entre el grupo de 20-29 años y el de 30-39 años, ambos pulmones aumentaron sus pesos promedios en 35%. En el grupo No-Mapuche, en ambos sexos, el peso promedio de estos órganos aumentó menos de un 10%. Estos resultados son comparados con otros grupos poblacionales del mundo y son un aporte al conocimiento morfológico de las vísceras torácicas.
Several factors can influence the weight of the thoracic and/or abdominal viscera. In order to know the average weight of the heart and lungs of Chilean individuals, information of these organs was obtained from 775 necropsies of fresh cadavers, between 2009-2013, considering ethnicity (non-Mapuche and Mapuche), age, sex and body mass index. We studied organs without apparent injury or disease. When considering age, the average heart weight showed an increase in both ethnic groups and both sexes. This increase was similar in male individuals from both ethnic groups, with a value of 13%. In female individuals there was an increase of 36% in the Mapuche ethnic group, while that of non-Mapuche was 8%. With regard to the lungs, there was no increase in their average weight in male individuals of Mapuche group, in females however, the increase was about 40%. Among the group of 2029 years and 3039 y, both lungs increased their average weights at 35%. In the non-Mapuche group, in both sexes, the average weight of these organs increased by less than 10%. These results are compared with other population groups in the world and are a contribution to morphological knowledge of the thoracic viscera.
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Tamanho do Órgão , Coração/anatomia & histologia , Pulmão/anatomia & histologia , Tórax/anatomia & histologia , Indígenas Sul-Americanos , Índice de Massa Corporal , Chile , Fatores Etários , Caracteres SexuaisRESUMO
El cuerpo calloso conecta ambos hemisferios cerebrales y se ubica en el fondo de la fisura longitudinal del cerebro. Con el propósito de complementar el conocimiento sobre esta importante estructura del sistema nervioso en nuestra población, determinamos diversos parámetros biométricos, que incluyeron su localización respecto a los márgenes anterior y posterior de los hemisferios cerebrales, longitud, espesor a diversos niveles, entre otras variables. Se utilizaron 20 cerebros frescos, de individuos adultos, a los cuales se fotografió la cara medial de sus hemisferios, los que fueron acompañados con una regla antes de obtener la fotografía, con el objetivo de trabajar sobre la imagen y, de este modo, registrar las variables planificadas. Estas medidas fueron registradas con un caliper digital de 0,05 mm de precisión. La distancia promedio obtenida entre la parte más prominente de la rodilla del cuerpo calloso y el margen anterior del hemisferio cerebral fue de 35,4 mm y, entre la parte más prominente del esplenio y el margen posterior del hemisferio cerebral fue de 52,8 mm. La longitud antero-posterior del cuerpo calloso fue, en promedio, 88,2 mm. La distancia antero-posterior promedio de la parte media de la rodilla fue 13,2 mm y la de la parte media del esplenio 15,7 mm. Los datos obtenidos son un aporte al conocimiento biométrico y morfológico de esta importante estructura comisural, en nuestro grupo poblacional.
The corpus callosum is a structure of white matter connecting the two cerebral hemispheres and is located at the bottom of the longitudinal fissure of the brain. In order to complement the understanding of this important structure of the nervous system in our population, we determined various biometric parameters, which included its location in relation to the anterior and posterior margins of the cerebral hemispheres, length, thickness at various levels, among other variables. To do this, we used 20 fresh brains of adult individuals which the medial aspect of the hemispheres was photographed, and were accompanied with a ruler before you get the picture, with the aim of working on the image and thus record the planned variables. The average distance obtained between the most prominent part of the knee of the corpus callosum and the anterior margin of the cerebral hemisphere was 35.4 mm and among the most prominent part of the splenium and the posterior margin of cerebral hemisphere was 52.8 mm. Antero-posterior length of the corpus callosum was on average 88.2 mm, the average antero-posterior diameter from the middle of the knee was 13.2 mm and that of the middle part of splenius 15.7 mm. The data obtained contribute to the biometric and morphological knowledge of this important commissural structure in our population group.
Assuntos
Humanos , Corpo Caloso/anatomia & histologia , Chile , Sistema Nervoso/anatomia & histologiaRESUMO
Based on the decrease of voluntary consumption of ethanol observed in rats of UChA (low ethanol consumer) and UChB (high ethanol consumer) strains, coincident to the use of a new issue of a commercial diet, the effects of two new diets devoid of animal food were studied. One of these diets (Diet 3) induced an increase of the voluntary consumption of ethanol in a proportion of UChA rats, in such a way that its frequency distribution curve resulted in a bimodal one because of the presence of individuals which drank as much alcohol as UChB rats. This diet is a useful tool for the study of eventual nutrimental factors which decrease ethanol intake.