RESUMO
BACKGROUND: The proportion of older people living with HIV (PLWH) has increased. Non-communicable diseases occur earlier in PLWH than in the general population. OBJECTIVE: The goal of this study was to estimate the prevalence of comorbidities in PLWH and cancer in a tertiary referral center in Mexico City. MATERIAL AND METHODS: In this retrospective study, we included PLWH > 40 years with a history of cancer, coming to Instituto Nacional de Cancerologia from 2010 through 2019. All patients needed to be on antiretrovirals for at least six months. Data collected included cancer type, comorbidities, frequency of polypharmacy, FRAX score and 10-year cardiovascular risk. Patients were evaluated for depression with the Beck Inventory Depression-II Scale. Variables associated to multimorbidity (2 or more comorbidities) were evaluated. RESULTS: Of 125 patients, 69% had at least one comorbidity; 32% had ≥ 2. Common comorbidities were dyslipidemia (54%), hypertension (19%), obesity (14%) and Diabetes (12%). In patients ≥ 50 years, 29 (62%) already undergone a densitometry and 9 (31%) had osteoporosis; 56 depression questionnaires were used: 30% had mild-to-severe depression. Being ≥ 50 years was associated with multimorbidity (aOR 2.57 (1.18-5.58), p = 0.017). CONCLUSIONS: A high prevalence of multimorbidity and poor screening of bone disease and mental health is reported in patients with PLWH and cancer. A holistic approach to the PLWH in the Infectious Diseases consultation is needed to improve the detection and management of non-communicable diseases, to go beyond viral suppression and towards an improved quality of life.
INTRODUCCIÓN: La proporción de personas mayores que viven con VIH (PVVIH) va en aumento, y las enfermedades no transmisibles ocurren antes en PVVIH comparado con la población general. OBJETIVO: El objetivo de este estudio fue estimar la prevalencia de las comorbilidades en PVVIH con cáncer de un centro de tercer nivel de la Ciudad de México. MÉTODOS: Este estudio retrospectivo incluyó todas las PVVIH > 40 años con cáncer, que acudieron al Instituto Nacional de Cancerología entre 2010 y 2019). Se incluyeron datos sobre el tipo de cáncer, comorbilidades y polifarmacia. Se calcularon la puntuación FRAX, el riesgo cardiovascular a 10 años, y se aplicó un cuestionario para evaluar depresión (Beck Inventory Depression-II Scale). RESULTADOS: De 125 pacientes, 69% tenía al menos una comorbilidad; 32% tenía ≥ 2. Las comorbilidades más comunes fueron dislipidemia (54%), hipertensión (19%), obesidad (14%) y diabetes (12%). En pacientes ≥ 50 años, 29% tenía una densitometría osea; 31% tenía osteoporosis. Se aplicaron 56 cuestionarios: 30% tenía algún grado de depresión. Tener ≥ 50 años se asoció con multimorbilidad (aOR 2.57, 1.18-5.58), p = 0.017. CONCLUSIONES: Se reporta una alta prevalencia de multimorbilidad en PVVIH y cancer, con pobre escrutinio de enfermedad ósea y salud mental. Se requiere un enfoque holístico para las PVVIH en la consulta de infectología, para mejorar el manejo de las enfermedades no transmisibles, yendo más alla de la supresión virológica.
Assuntos
Infecções por HIV , Multimorbidade , Neoplasias , Humanos , México/epidemiologia , Masculino , Pessoa de Meia-Idade , Feminino , Estudos Retrospectivos , Infecções por HIV/epidemiologia , Infecções por HIV/tratamento farmacológico , Neoplasias/epidemiologia , Prevalência , Adulto , Idoso , Depressão/epidemiologia , Comorbidade , Fatores EtáriosRESUMO
BACKGROUND: Hematopoietic stem cell transplant (HSCT) recipients are among patients with highest risk of adverse coronavirus disease 2019 (COVID-19) outcomes. OBJECTIVE: We compared clinical outcomes in post-HSCT patients with COVID-19 before and during the Omicron period. STUDY DESIGN: This was a retrospective study including patients post-HSCT with severe acute respiratory syndrome coronavirus 2 infection from April 2020 to March 2023 at Instituto Nacional de Cancerología, Mexico City. We describe their clinical characteristics and report the variables associated with severe clinical disease, hospitalization, and death. RESULTS: Fifty-three patients were included; 31 (58.5%) from the pre-Omicron period and 22 (41.5%) from the Omicron period. Median age was 42-years old (interquartile range 26-53), and 31 patients (59%) were men. Only four patients (16%) had received a vaccine prior to COVID-19 diagnosis in the pre-Omicron period versus 20 (91%) in the Omicron period (p < 0.001). COVID-19 severe cases were more common before Omicron: seven patients (23%) versus two patients (9%). Only one patient (3%) received an antiviral in the pre-Omicron period compared to 11 patients (50%) during the Omicron period (p < 0.01). COVID-19-associated mortality was almost double in the pre-Omicron period (16% vs. 9%, p = 0.6). CONCLUSIONS: This study reports patients with a high proportion of severe outcomes during the first 2 years of the pandemic. Outcomes improved during Omicron with better access to vaccines and antivirals and no in-hospital cases. Variables associated with worse outcomes were similar to other reports. Strengthening infection control measures in the hospital and better access to preventive strategies and therapeutic options are mandatory in these high-risk patients.
Assuntos
COVID-19 , Transplante de Células-Tronco Hematopoéticas , SARS-CoV-2 , Humanos , COVID-19/epidemiologia , COVID-19/mortalidade , COVID-19/prevenção & controle , Masculino , México/epidemiologia , Transplante de Células-Tronco Hematopoéticas/efeitos adversos , Adulto , Pessoa de Meia-Idade , Feminino , Estudos Retrospectivos , Hospitalização/estatística & dados numéricos , Transplantados/estatística & dados numéricos , Vacinas contra COVID-19/administração & dosagemRESUMO
BACKGROUND: Health care workers (HCWs) are occupationally exposed to severe acute respiratory syndrome coronavirus (SARS-CoV-2). This study aimed to characterize COVID-19 in HCWs at an oncology hospital in Mexico City over 2-years, identify factors associated with severity, and establish transmission dynamics. METHODS: This retrospective study included HCWs with confirmed COVID-19. Socio-demographic, clinical, and outcome data were retrieved from March 2020 to March 2022. We compared the proportion of HCWs affected in each wave. A survey on COVID-19 transmission dynamics was conducted in a subgroup. RESULTS: We included 1,058 workers. The risk of COVID-19 was higher during the Omicron odds ratio (OR 2.10, 95% confidence interval [CI] 1.77-2.50, P < .001). Age ≥41 years old (OR 6.32, 95% CI 2.4-16.62) and being administrative staff (OR 5.51, 95% CI 1.72-17.6) or medical staff (OR 6.82, CI 95% 1.77-26.23), compared to nursing staff, were associated with severity. Vaccination with ≥1 vaccine against SARS-CoV-2 was a protective factor for severe disease (OR 0.04, 95% CI 0.005-0.331). CONCLUSIONS: This study highlights the impact of COVID-19 on HCWs in a cancer hospital in Mexico City and the impact of vaccination as a protective factor against severity.
RESUMO
Los adultos jóvenes constituyen gran parte de la población paraguaya y se considera que los conocimientos y prácticas sobre salud bucodental están muy relacionados al nivel de instrucción, el objetivo de este estudio fue evaluar el nivel de conocimientos y prácticas sobre salud bucodental de estudiantes de posgrado de la Carrera de Enfermería de la Facultad de Ciencias de la Salud de la Universidad Católica de Asunción (CE FCSUCA), en el 2018. Estudio observacional descriptivo de corte transversal con componente analítico en el que se incluyeron a todos los estudiantes de posgrado entre mayo y junio de 2018. La recolección de datos se realizó mediante un cuestionario sobre salud bucodental autoadministrado y de carácter anónimo. Los datos se asentaron en una planilla electrónica, y fueron analizados utilizando el Programa estadístico IBMSSPS 23.0. La muestra estuvo constituida por 166 estudiantes, en su mayoría del sexo femenino (75,3%), de entre 20 y 29 años (54,8%), cursando algún programa de especialización (57,8% y pertenecientes al área de la salud (94%). El 57,83% y el 55,42% de los estudiantes presentaron conocimientos y prácticas de salud bucodental de nivel regular, respectivamente. Se encontró asociación entre nivel de conocimiento y de práctica y entre el nivel de conocimiento y la edad. Se concluye que los niveles de conocimientos y prácticas sobre salud bucodental en los estudiantes de posgrado fueron deficientes por lo que se propone la implementación de estrategias educativas de concienciación en el área(AU)
Young adults constitute a large part of the Paraguayan population and considering that oral health knowledge and practices are closely related to the level of education, the objective of this study was to evaluate the level of knowledge and practices on oral health of postgraduate students of the Nursing Career of the Faculty of Health Sciences of the Catholic University of Asunción (CE FCSUCA), in 2018. The design was descriptive, cross-sectional with an analytical component in which all postgraduate students were included in May and June 2018. Data collection was carried out through a questionnaire on oral health self-administered and anonymous. The data were recorded in an electronic spreadsheet and analyzed using the IBMSSPS 23.0 Statistical Program. The sample consisted of 166 students, mostly female (75.3%), between 20 and 29 years old (54.8%), studying some specialization program (57.8%) and belonging to the area of Health (94%). 57.83% and 55.42% of the students presented knowledge and practices of oral health at the regular level, respectively. An association was found between the level of knowledge and practice and between the level of knowledge. It is concluded that the levels of knowledge and practices on oral health in the postgraduate students were insufficient, so the implementation of educational awareness strategies in the area is proposed(AU)
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Conhecimentos, Atitudes e Prática em Saúde , Saúde Bucal/educação , Paraguai , Periodontite/etiologia , Estudos Transversais , Cárie Dentária/etiologia , Educação de Pós-Graduação em Enfermagem , Gengivite/etiologiaRESUMO
O objetivo do estudo foi avaliar o efeito da inclusão de extrato de própolis na digestibilidade e na palatabilidade de dietas para cães. Foram realizados dois experimentos, sendo o primeiro constituído por um ensaio de digestibilidade, com a inclusão de diferentes extratos de própolis (FT0,55, FT0,59, FT2,59, FT2,11). Com base nos resultados do primeiro ensaio, foi definido o extrato FT0,59 a ser utilizado nos demais experimentos, misturado em crescentes níveis à dieta, resultando em outras concentrações de apiginina. Ambos os ensaios de digestibilidade utilizaram dez cães da raça Beagles, os quais foram alojados em gaiolas metabólicas. A palatabilidade foi avaliada pela preferência alimentar e pela primeira escolha, sendo utilizados 20 cães de quatro diferentes raças. No primeiro ensaio de digestibilidade, somente a inclusão do extrato de própolis FT2,11 diminuiu o valor do coeficiente de digestibilidade aparente (CDA) da matéria seca (MS). Já no segundo ensaio, a inclusão crescente do extrato de própolis FT0,79 melhorou linearmente os CDA da proteína bruta (PB), extrato etéreo em hidrólise ácida (EEA), extrativos não nitrogenados (ENN), MS e energia metabolizável (EM) das dietas. A inclusão de extrato de própolis favoreceu a palatabilidade da dieta. Os flavonoides podem ser adicionados na dieta de cães como nutracêuticos em concentrações menores do que 2,11mg/kg de MS da dieta, sem alterar a digestibilidade.(AU)
The aim of the study was to evaluate the effect of inclusion of propolis extract digestibility and palatability. Two experiments were conducted, the first consisting of a digestibility trial with the inclusion of different propolis extracts (FT0,55, FT0,59, FT2,59, FT2,11). Based on the results of the first test, the extract being used in the other experiments, so the chosen FT0,59 extract was mixed in increasing levels in diets resulting in different apiginin concentrations. the diet was defined. Both digestibility assays beagle dogs 10, which were housed in metabolic cages were used. Palatability was assessed by food preference and first choice, 20 dogs of different breeds being used. In the first digestibility trial, only the inclusion of propolis extract FT2,11 decreased the value of the apparent digestibility coefficient (ADC) of dry matter (DM). In the second trial, increasing inclusion of propolis extract FT0,59 linearly improved the ADC of crude protein (CP), ether extract in acid hydrolysis (EEA), nitrogen free extract (NFE), MS and metabolizable energy (ME) of the diets. The inclusion of propolis extract favored the palatability of the diet. Flavonoids can be added in the diet of dogs as nutraceuticals in concentrations lower than 2.11mg/kg of DM of the diet without altering digestibility.(AU)
Assuntos
Animais , Cães , Própole/análise , Própole/metabolismo , Própole/uso terapêutico , Ração Animal/análise , Preferências Alimentares , Comportamento do ConsumidorRESUMO
O objetivo do estudo foi avaliar o efeito da inclusão de extrato de própolis na digestibilidade e na palatabilidade de dietas para cães. Foram realizados dois experimentos, sendo o primeiro constituído por um ensaio de digestibilidade, com a inclusão de diferentes extratos de própolis (FT0,55, FT0,59, FT2,59, FT2,11). Com base nos resultados do primeiro ensaio, foi definido o extrato FT0,59 a ser utilizado nos demais experimentos, misturado em crescentes níveis à dieta, resultando em outras concentrações de apiginina. Ambos os ensaios de digestibilidade utilizaram dez cães da raça Beagles, os quais foram alojados em gaiolas metabólicas. A palatabilidade foi avaliada pela preferência alimentar e pela primeira escolha, sendo utilizados 20 cães de quatro diferentes raças. No primeiro ensaio de digestibilidade, somente a inclusão do extrato de própolis FT2,11 diminuiu o valor do coeficiente de digestibilidade aparente (CDA) da matéria seca (MS). Já no segundo ensaio, a inclusão crescente do extrato de própolis FT0,79 melhorou linearmente os CDA da proteína bruta (PB), extrato etéreo em hidrólise ácida (EEA), extrativos não nitrogenados (ENN), MS e energia metabolizável (EM) das dietas. A inclusão de extrato de própolis favoreceu a palatabilidade da dieta. Os flavonoides podem ser adicionados na dieta de cães como nutracêuticos em concentrações menores do que 2,11mg/kg de MS da dieta, sem alterar a digestibilidade.
The aim of the study was to evaluate the effect of inclusion of propolis extract digestibility and palatability. Two experiments were conducted, the first consisting of a digestibility trial with the inclusion of different propolis extracts (FT0,55, FT0,59, FT2,59, FT2,11). Based on the results of the first test, the extract being used in the other experiments, so the chosen FT0,59 extract was mixed in increasing levels in diets resulting in different apiginin concentrations. the diet was defined. Both digestibility assays beagle dogs 10, which were housed in metabolic cages were used. Palatability was assessed by food preference and first choice, 20 dogs of different breeds being used. In the first digestibility trial, only the inclusion of propolis extract FT2,11 decreased the value of the apparent digestibility coefficient (ADC) of dry matter (DM). In the second trial, increasing inclusion of propolis extract FT0,59 linearly improved the ADC of crude protein (CP), ether extract in acid hydrolysis (EEA), nitrogen free extract (NFE), MS and metabolizable energy (ME) of the diets. The inclusion of propolis extract favored the palatability of the diet. Flavonoids can be added in the diet of dogs as nutraceuticals in concentrations lower than 2.11mg/kg of DM of the diet without altering digestibility.
Assuntos
Animais , Cães , Preferências Alimentares , Própole/análise , Própole/metabolismo , Própole/uso terapêutico , Ração Animal/análise , Comportamento do ConsumidorRESUMO
El carcinoma hepatocelular fibrolamelar (CHC-FL) es una variante poco frecuente de CHC convencional, representa el 0,85 al 16% de todos los carcinomas hepatocelulares. Se presenta en personas jóvenes, sin antecedente de enfermedad hepática crónica subyacente, alrededor del 65-85% de estos tumores ocurren en pacientes menores de 40 años. Para su diagnóstico, las modalidades de imagen cumplen un papel importante tanto el ultrasonido, tomografía y resonancia magnética principalmente ésta última podría aportar sustancialmente al diagnóstico. Se presenta el caso de un joven de 16 años con diagnóstico histopatológico de hepatocarcinoma fibrolamelar y su correlación con las diferentes modalidades de imagen, el cual fue sometido a trasplante hepático, se realiza la revisión del mismo dada la importancia del diagnóstico por imagen y las alternativas terapéuticas en estos casos.
Fibrolamellar hepatocellular carcinoma (CHC-FL) is a rare variant of conventional HCC, representing 0.85 to 16% of all hepatocellular carcinomas. It occurs in young people, without a history of underlying chronic liver disease, about 65-85% of these tumors occur in patients under 40 years. For its diagnosis, imaging modalities play an important role, both ultrasound, tomography and magnetic resonance, mainly the latter could contribute substantially to the diagnosis. We present the case of a 16-year-old boy with a histopathological diagnosis of fibrolamellar hepatocellular carcinoma and its correlation with the different imaging modalities, which underwent hepatic transplantation. He was reviewed, given the importance of imaging diagnosis and alternatives. therapeutic in these cases.
Assuntos
Humanos , Masculino , Adolescente , Carcinoma Hepatocelular , Fígado , Neoplasias , Diagnóstico por Imagem , Transplante de FígadoRESUMO
El empoderamiento es el proceso por el cual las personas fortalecen sus capacidades, confianza, visión y protagonismo para impulsar cambios positivos de las situaciones que viven, por lo que es un desafío para los profesionales de enfermería en todos los niveles de asistencia. El objetivo de esta investigación es realizar un análisis del empoderamiento de los enfermeros asistenciales de cuidados intensivos de adultos en el Hospital Central del Instituto de Previsión Social en la ciudad de Asunción, Paraguay. Se realizó un estudio cualitativo con enfoque fenomenológico. Los datos se recolectaron a través de entrevistas semi estructuradas grabadas cuyas preguntas se fundamentaron en seis categorías de estudio: sentido de pertenencia, autonomía, liderazgo, trabajo en equipo, participación en asociaciones y percepción de empoderamiento. La muestra se determinó por conveniencia y saturación alcanzando a 17 sujetos. Las respuestas de los participantes se agruparon en ideas comunes para deducir los resultados. En el análisis se tuvo en cuenta las propuestas de Zimmerman y Benner en materia de empoderamiento y desarrollo profesional de enfermería respectivamente. En el grupo estudiado se distinguen atributos como autonomía y trabajo en equipo que favorecen el empoderamiento individual. Sin embargo, estas cualidades contrastan con un débil sentido de pertenencia, una práctica relativa del liderazgo y escasa participación en asociaciones. En consecuencia, el empoderamiento de enfermería en las unidades de cuidados intensivos estudiadas es un proceso incipiente que requiere intervenciones efectivas para consolidarse y fortalecer la identidad profesional(AU)
Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Poder Psicológico , Unidades de Terapia Intensiva , Enfermeiras e Enfermeiros/psicologia , Paraguai , Autonomia Profissional , LiderançaRESUMO
INTRODUCTION: Norovirus (NoV) are RNA viruses highly contagious, stable in the environment, genetically variable, and the most common cause of viral sporadic acute gastroenteritis worldwide. This is the first study carried out in Concepcion, Chile, to investigate the presence of NoV as an etiologic agent of viral diarrheas in hospitalized children. Objective. To detect the presence and genogroup of NoV in children with diarrhea and to compare it with rotavirus (RV) and adenovirus (AdV). MATERIAL AND METHODS: A one year descriptive, prospective study in children 0-14 years old. A single diarrheic stool sample per patient was analyzed for the presence of NoV, RV and AdV. Clinical data were unknown at the moment of sampling. Real time RT-PCR with Taqman™ probes for NoV and the immunocromatography VIKIA™ kit for RoV /AV detection were used. RESULTS: Infection for NoV (25.5%) was significantly higher than for RV (15.9%) and AdV (6.2%). It was even greater in infants younger than 2yr. old (n: 103): NoV 34%, RV 17.5%, AdV 7.8%. Children 2-4 yr. old had 11.8% infection of NoV and RV. Children older than 4, only had 12% RV and 4% AdV. Children hospitalized for diarrhea (n: 92) had: 21.7% of both NoV and RV, and 7.6% AdV; whereas children hospitalized for other causes (n: 53) had 32.1% NoV,5.7% RV and 3.8% AV. The proportion of infection due to NoV was significantly higher in males (31.5%) than in females (19.4%). The average frequency during the year was higher for NoV (30.3%) than for RV (14.7%) except in summer. CONCLUSION: The presence of NoV was higher than RV in children with diarrhea. NoV infection showed defined characteristics regarding age, gender, seasonal occurrence and nosocomial transmission that are important epidemiological features.
Assuntos
Adenoviridae/isolamento & purificação , Fezes/virologia , Gastroenterite/virologia , Norovirus/isolamento & purificação , Rotavirus/isolamento & purificação , Adenoviridae/genética , Adolescente , Estudos de Casos e Controles , Criança , Pré-Escolar , Chile/epidemiologia , Infecções Comunitárias Adquiridas/virologia , Infecção Hospitalar/virologia , Diarreia/virologia , Feminino , Gastroenterite/diagnóstico , Gastroenterite/epidemiologia , Humanos , Lactente , Recém-Nascido , Masculino , Norovirus/genética , Estudos Prospectivos , RNA Viral/sangue , Reação em Cadeia da Polimerase em Tempo Real , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Rotavirus/genéticaRESUMO
Introduction: Norovirus (NoV) are RNA viruses highly contagious, stable in the environment, genetically variable, and the most common cause of viral sporadic acute gastroenteritis worldwide. This is the first study carried out in Concepcion, Chile, to investigate the presence of NoV as an etiologic agent of viral diarrheas in hospitalized children. Objective. To detect the presence and genogroup of NoV in children with diarrhea and to compare it with rotavirus (RV) and adenovirus (AdV). Material and Methods: A one year descriptive, prospective study in children 0-14 years old. A single diarrheic stool sample per patient was analyzed for the presence of NoV, RV and AdV. Clinical data were unknown at the moment of sampling. Real time RT-PCR with Taqman™ probes for NoV and the immunocromatography VIKIA™ kit for RoV /AV detection were used. Results: Infection for NoV (25.5%) was significantly higher than for RV (15.9%) and AdV (6.2%). It was even greater in infants younger than 2yr. old (n: 103): NoV 34%, RV 17.5%, AdV 7.8%. Children 2-4 yr. old had 11.8% infection of NoV and RV. Children older than 4, only had 12% RV and 4% AdV. Children hospitalized for diarrhea (n: 92) had: 21.7% of both NoV and RV, and 7.6% AdV; whereas children hospitalized for other causes (n: 53) had 32.1% NoV,5.7% RV and 3.8% AV. The proportion of infection due to NoV was significantly higher in males (31.5%) than in females (19.4%). The average frequency during the year was higher for NoV (30.3%) than for RV (14.7%) except in summer. Conclusion: The presence of NoV was higher than RV in children with diarrhea. NoV infection showed defined characteristics regarding age, gender, seasonal occurrence and nosocomial transmission that are important epidemiological features.
Introducción: Los norovirus (NoV) son virus ARN altamente contagiosos, resistentes, variables genéticamente y una de las etiologías más frecuente de gastroenteritis viral esporádica mundial. Este es el primer trabajo en Concepción, Chile, de búsqueda de NoV como etiología viral de diarreas en niños hospitalizados. Objetivo: Determinar la presencia y genogrupo de NoV en niños con diarrea y compararla con la frecuencia de rotavirus (RV) y adenovirus (AdV). Material y Método: Estudio descriptivo, prospectivo de un año, en niños de 0-14 años ingresados por diarrea aguda o que la adquirieron dentro del hospital. La muestra de deposiciones diarreica se tomó una sola vez por paciente. Las fichas clínicas se analizaron al finalizar el estudio etiológico. Para la detección de NoV se utilizó RPC-TR a en tiempo real con sondas Taqman® y para detección de RV/AdV, el kit VIKIA® de inmunocromatografia. Resultados: La infección por NoV (25,5%) fue significativamente más frecuente que por RV (15,9%) y AdV (6,2%). La mayor presencia de infección fue en pacientes bajo2 años de edad (n: 103): NoV 34,0%, RV 17,5%, AdV 7,8%. La detección en niños hospitalizados por diarrea fue: NoV y RV 21,7% cada uno; AdV 7,6%. En niños con diarrea nosocomial hospitalizados por otras causas se detectó NoV en 32,1%, RV en 5,7% y AdV en 3,8%. La presencia de NoV fue significativamente mayor en varones (31,5%) que en niñas (19,4%). El promedio de diarreas durante el año fue mayor para NoV (30,3%) que para RV(14,7%), excepto en verano. Discusión y Conclusión: La presencia de NoV fue mayor que la de RoV en niños con diarrea y con una tendencia nosocomial que podría deberse a las características del virus que favorece infecciones de ambiente confinado, como hospitales, asilos y cruceros. La infección por NoV presentó características definidas, en edad, género, ocurrencia estacional y relevancia nosocomial, que aportan datos epidemiológicos importantes.