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RESUMEN: El objetivo del presente trabajo fue evaluar el efecto de las microemulsiones de aceite esencial de romero (AER) y árbol de té (AET) sobre el eritrocito humano y microorganismos patógenos. Para ello, se elaboraron microemulsiones de AER y AET al 8.0% (v/v), 5.0% (v/v) y 2.5% (v/v). Las microemulsiones fueron probadas sobre el eritrocito humano para determinar el porcentaje de hemólisis, el porcentaje de inhibición de hemólisis y su actividad antibacterial contra E. coli O157:H7 y S. aureus. Las microemulsiones con AER no presentaron actividad hemolítica significativa, caso contrario con las microemulsiones de AET al 8.0% (≈70%) y 5.0% (33%) que presentaron mayor actividad hemolítica. Las microemulsiones de AER protegieron significativamente al eritrocito contra la presencia de radicales libres, en comparación con aquellas de AET (p< 0.05). Además, las emulsiones de AET al 8.0% mostraron efectos antibacterianos contra E. coli O157:H7 y S. aureus mientras que AER al 8.0% solo mostraron efecto contra E. coli O157:H7. La limitante del estudio fue que no utilizamos células nucleadas para establecer si los aceites esenciales dañan el material nuclear. Sin embargo, observamos que el tipo y la cantidad de aceite utilizado pueden tener implicaciones serias sobre la membrana eritrocitaria. Se concluye que las microemulsiones de AER presentaron mejor efecto protector eritrocitario, mientras que las microemulsiones de AET presentaron mejor actividad antibacterial contra las bacterias estudiadas, pero con mayor efecto tóxico sobre el eritrocito.

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ABSTRACT: The aim of the study was to evaluate the effect of microemulsions of rosemary (AER) and tea tree (AET) essential oils on human erythrocyte and pathogen bacteria. Microemulsions of each oil were prepared at 8.0% (v/v), 5.0% (v/v) and 2.5% (v/v), and they were tested on human erythrocyte to determine the hemolysis percentage, hemolysis inhibition percentage and the antibacterial capacity against E. coli O157:H7 and S. aureus. All AER microemulsions showed no significant hemolytic activity. On the contrary, AET microemulsions showed hemolytic effect but those in concentrations of 8.0% (≈70 %) and 5.0% (33%) showed the highest effect. In addition, AER microemulsions showed protective effect against free radicals in comparison with the AET microemulsions (p< 0.05). On the other hand, the AET microemulsion at 8.0% showed antibacterial effect against E. coli O157:H7 and S. aureus, and the AER at 8.0% showed antibacterial effect against E. coli O157:H7. The limitation of this study was that nucleated cells were not used to observe the damage of the essential oils on nuclear material. However, the observed damage of erythrocyte's membrane is depending on type and amount of used oil. Therefore, it can be concluded that the AER microemulsions showed better protective effect of erythrocytes, while AET microemulsions showed better antibacterial effect against the tested bacteria, although with toxic effect on the erythrocytes.

RESUMO

INTRODUCTION: Hospital malnutrition is a prevalent problem that cause higher morbidity and mortality, poorer response to treatment and higher hospital stay and cost. OBJECTIVES: To determine the prevalence and factors associated with hospital malnutrition in a peruvian General Hospital. METHODS: Cross-sectional study including 211 hospitalized patients in Medicine and Surgery wards. Demographic, clinical and anthropometrical indicators' data was collected. Multivariate analysis was binary logistic regression. All tests had a significance level of 5% (p < 0.05). RESULTS: Prevalence of hospital malnutrition was 46.9%. Prevalences of caloric and protein malnutrition were 21.3% and 37.5%, respectively. Bivariate analysis found that hospitalization in Surgery wards was associated with a major risk of caloric (OR = 4.41, IC 95% [1.65-11.78]) and protein malnutrition (OR = 2.52, IC 95% [1.297-4.89]). During the analysis of quantitative variables, significant associations between number of comorbidities and caloric malnutrition (p = 0.031) was found, and also between the beginning of food intake changes and the presence of protein malnutrition (p = 0.031). Multivariate analysis showed significant association between diagnosis of neoplasm and presence of caloric malnutrition (OR = 5.22, IC [1.43-19.13]). CONCLUSIONS: Prevalence of hospital malnutrition was near 50%, as in similar studies. Protein-caloric malnutrition prevalences obtained, differ from the ones in a previous study in this hospital, which is explained by the different diagnostic criteria and particular characteristics of groups of patients, such as procedence ward and comorbidities. An association between protein-caloric and hospitalization in a Surgery ward was found; the reasons should be investigated in further studies.

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Introducción: La desnutrición hospitalaria es un problema prevalente que genera mayor morbi-mortalidad, peor respuesta al tratamiento, mayor estancia y costo hospitalario. Objetivos: Determinar la prevalencia y factores asociados a desnutrición hospitalaria en un hospital general peruano. Métodos: Estudio analítico transversal de 211 pacientes en servicios de Medicina y Cirugía. Se analizó variables demográficas, clínicas e indicadores antropométricos. El análisis multivariado fue de regresión logística binaria. El nivel de significancia fue 5% (p < 0,05). Resultados: La prevalencia de desnutrición hospitalaria fue 46.9% y las de desnutrición calórica y proteica fueron 21,3% y 37,5% respectivamente. En el análisis bivariado, estar hospitalizado en el servicio de Cirugía se asoció a un mayor riesgo de desnutrición calórica (OR = 4,41, IC 95% [1,65-11,78]) y proteica (OR = 2,52, IC 95% [1,30-4,90]). Hubo asociación significativa entre el número de comorbilidades del paciente y desnutrición calórica (p = 0,031), y el tiempo de cambio de ingesta alimentaria y presencia de desnutrición proteica (p = 0,031). El análisis multivariado mostró asociación significativa entre el diagnóstico de neoplasia y la presencia de desnutrición calórica (OR = 5,22, IC 95% [1,43-19,13]). Conclusiones: La prevalencia de desnutrición hospitalaria fue cerca del 50%, coincidiendo con estudios similares. Las prevalencias de desnutrición calórica/proteica halladas difieren de las de un estudio anterior en este hospital, explicándose por parámetros de diagnóstico diferentes y características particulares de las poblaciones, como el servicio de procedencia y comorbilidades. Se encontró asociación entre desnutrición proteica/calórica y estar hospitalizado en el servicio de Cirugía; las razones deben investigarse en estudios posteriores.

Assuntos

Hospitais Gerais/estatística & dados numéricos , Desnutrição/epidemiologia , Adulto , Idoso , Estudos Transversais , Feminino , Hospitais Gerais/economia , Humanos , Tempo de Internação , Masculino , Desnutrição/economia , Pessoa de Meia-Idade , Peru/epidemiologia , Prevalência , Desnutrição Proteico-Calórica/epidemiologia , Fatores Socioeconômicos

RESUMO

OBJECTIVE: To evaluate the effect of body mass index (BMI) on PSA in northeast Mexican patients included in prostate cancer (Pca) early detection screening campaigns offered by our institution. MATERIAL AND METHODS: One hundred and ninety seven patients came voluntarily to our Pca early detection screening campaigns. EXCLUSION CRITERIA: PSA >10 ng/dl, patients on 5-α Reductase inhibitors or hormonal replacement. Overweight and obesity were considered when BMI was between 25-29.9 and ≥30 kg/m(2) respectively. Simple linear and multiple regression were used in the statistical analysis. Mean and standard deviation were utilized to evaluate spread and normal distribution. P values <0.05 were considered statistically significant. RESULTS: One hundred and fifty two patients were included in this study. Forty four percent (83) and 30.3%(46) presented with overweight and obesity, respectively. Mean BMI was 28.16 kg/m(2) (SD 1.77). A statistically significant negative effect of BMI on PSA was observed in the linear regression. This effect persisted when adjusted for age in the multiple regression model. A decrease of 0.085 ng/dl for every unit of BMI (p <0.001) was observed in the simple linear regression. This value was 0.07 in the multiple regression (p=0.006) CONCLUSIONS: A higher negative effect of BMI on PSA was found in comparison to published literature. A higher proportion of patients with BMI >25 kg/m(2) than the national mean was observed. A multicentric national study is needed in order to challenge these results.

Assuntos

Índice de Massa Corporal , Antígeno Prostático Específico/sangue , Humanos , Masculino , México , Pessoa de Meia-Idade , Estudos Prospectivos

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A variant of the standard voter model, where a randomly selected site of a one-dimensional lattice (d=1) adopts the state of another site placed at a distance r from the previous one, is proposed and studied by means of numerical simulations that are rationalized with the aid of dynamical and finite-size scaling arguments. The distance between the two sites is also selected randomly with a probability given by P(r)∝r(-(d+σ)), where σ is a control parameter. In this way one can study how the introduction of these long-range interactions influences the dynamic behavior of the standard voter model with nearest-neighbor interactions. It is found that the dynamics strongly depends on the range of the interactions, which is parameterized by σ, leading to an interesting effective multidimensional crossover behavior, as follows. (a) For σ<1 ordering is no longer observed and the average interface density [ρ(t)] assumes a steady state in the thermodynamic limit. Instead, for finite-size systems an exponential decay with a characteristic time (τ) that increases with the size is observed. This behavior resembles the scenario corresponding to the short-range voter model for d>2, as well as the case of both scale-free and small-world networks. (b) For σ>1, an ordering dynamics is observed, such that ρ(t)∝t(-α), where the exponent α increases with σ until it reaches the value α=1/2 for σ≥5, which corresponds to the behavior of the standard voter model with short-range interactions in d=1. (c) Finally, for σ≈1 we show evidence of a critical-type behavior as in the case of the critical dimension (d(c)=2) of the standard voter model.