RESUMO
Leprosy has been a challenge in different areas of medicine; in underdeveloped countries it remains a public health problem, in which the social and economic problems facilitate the disease persistence. The diagnosis and consequently the treatment are delayed due to the clinical polymorphism of leprosy, which especially at the beginning the manifestations are not as evident, as is the case of diffuse lepromatous leprosy. This favors the disabilities and the development of the reaction episodes. Fortunately, reaction episodes have decreased with the use of multidrug therapy, and better control of the type 2 reactions has been managed with the use of thalidomide, as in Lucio's phenomenon.
Assuntos
Humanos , Masculino , Feminino , Fenômenos Fisiológicos da Pele/efeitos dos fármacos , Úlcera Cutânea/patologia , Hanseníase Virchowiana/tratamento farmacológico , Hansenostáticos/administração & dosagem , Úlcera Cutânea/terapia , Mycobacterium leprae/efeitos dos fármacosRESUMO
Con el avance de las tecnologías de la información y su impacto en todas las áreas de la sociedad se evidencia la necesidad de obtener información útil y relevante, tarea esta designada para su cumplimiento a los bibliotecarios. El presente trabajo expone la confección de los blogs sobre recursos informativos referentes a las infecciones de trasmisión sexual, el VIH, el SIDA y el alcoholismo, con el objetivo de propiciar a los profesionales y técnicos de la salud de la provincia de Camagüey el acceso a las distintas fuentes de información que abarquen temas relacionados con el tópico que permita contribuir tanto a la investigación como a la práctica médica. Para la creación de estos recursos informativos se tuvieron en cuenta las necesidades informativas; dentro de ellas los principales problemas de salud identificados en la provincia y el proyecto institucional ITS/VIH/SIDA. Se utilizó el blog, que es el servicio genérico para construir sitios de diversa índole que tienen como propósito comunicar información a través de la Web. Los resultados obtenidos facilitan el acceso a la información necesaria para la toma de decisiones. Los productos se encuentran expuestos en el sitio Web del Centro Provincial de Información de Ciencias Médicas de Camagüey: http://www.sld.cu/sitios/cpicm-cmw/
With the advancement of information technology and its impact on all areas of society are clearly needed to obtain useful and relevant information, a task designated for compliance by librarians. The present study describes the preparation of blogs about information resources relating to STD/ HIV/AIDS and alcoholism in order to encourage professionals and health technicians extent of different sources of information covering topics related to the topic that can contribute to both research and practice and medical decision making. For the creation of these products, we took into account the information needs: within them the main health problems identified in the province and the institutional project STI/HIV/AIDS. We used the blog that is the generic service to build sites of various kinds that are intended to communicate information through the Web. The results provide access to the information necessary for decision making. The products are on display in the website of the Provincial Information Center of Medical Sciences
Assuntos
Síndrome da Imunodeficiência Adquirida , Blogging , Gestão da Informação em Saúde , HIV , Serviços de Informação , Infecções Sexualmente TransmissíveisRESUMO
Se realizó un estudio de evaluación para diagnosticar y determinar las principales incidencias en la preservación y conservación del fondo documental de la biblioteca de medicina natural y tradicional de Camagüey, tanto desde el punto de vista de los soportes como de su depósito a partir de indicadores y variables preestablecidas en lineamientos existentes, en el período de septiembre de 2008 a septiembre de 2009, con el objetivo de evaluar el estado de conservación y preservación de la colección de esta biblioteca y proponer acciones que eviten el incremento del deterioro. Se realizó la evaluación a partir del balance de las fuerzas internas y externas (DAFO). Se empleó la técnica de muestreo basado en el criterio de selección de frecuencia de uso. Se aplicó el análisis documental para determinar las principales afectaciones en cada unidad de observación. Se utilizó el formulario I propuesto por el programa DIAGNOS del Instituto de Historia de Cuba. Los resultados del diagnóstico se presentan en tablas. La evaluación final del estado de conservación de los fondos fue de regular. Se concluye que las principales afectaciones a los documentos se producen, casi en su totalidad, por la mala manipulación y las deficientes condiciones de su depósito, no por la presencia de plagas, insectos o roedores, y deben desarrollarse acciones con vista a favorecer la preservación y la conservación de los fondos de la biblioteca.
An evaluation study was conducted to diagnose and to determine the major incidences in preservation and conservation of documentary collection of natural and traditional medicine library of the city of Camagüey from the supports point of view and of its book stack from the pre-established indicators and variables in available lineaments during September, 2008 to September, 2009 to assess the conservation and preservation conditions of the collection of this library and also to propose actions avoiding the increase of deterioration. Authors made an evaluation from the internal and external forces balance (DAFO). We used the sampling technique base on selection criterion of use frequency applying a documentary analysis to determine the major affectations in each unit of observation and the use of the Nro.1 form for the DIAGNOS program of the Cuban Institute of History. Diagnosis results are showed in tables. The final classification of the conservation of collections was of regular. We conclude t hat the major affectations to documents are produced almost in its totality, due to the poor manipulation and to the deficient conditions of its book stack, not due to presence of epidemic, insects or rodents proposing actions to be developed to favor the care of the library's collections.
Assuntos
Armazenamento e Recuperação da Informação , Bibliotecas Médicas , Registros , Serviços de InformaçãoRESUMO
Tuberculoid (TT) and lepromatous leprosy (LL) develop in the human host depending on his ability to trigger a specific cellular immune response(CIR). Different genes have been demonstrated in susceptibility/protection and may explain the forms of leprosy. The major histocompatibility complex (MHC) play an important role. The aim of the study was to explore the contribution of human leukocyte antigen (HLA) DRB1, DQA1, DQB1 and DQ promoter genes in LL Mexican patients. Six families (26 LL, three TT patients and 27 controls) were analyzed; 114 unrelated patients were compared with 204 controls. Class I typing was done by the standard microlymphocytotoxicity and class II typing using PCR-SSOP. Haplotype segregation correlated with specific CIR in vivo and in vitro using lepromin. Haplotype sharing was significantly deviated in the affected sibs (p=0.01). Six healthy sibs were non-responders to lepromin and four of them were DQ1 homozgotes. DQ1 was significantly associated with LL and with non-responders. We set up macrophage activation experiments after infecting these cells with 5x10(6) bacilli to demonstrate if elimination occurred in the context or DQ1. When DQ1 was present on macrophages and on T cells, bacteria were poorly eliminated from the cell (32%) while when absent, 76% of the individuals were able to eliminate the bacilli (p=0.03). DRB1*1501 DQA1*0102-DQB1*0602 (DQ1 subtype) was significantly increased in the patients, indicating its participation in susceptibility. QBP 5.11/5.12 promoter present in the mentioned haplotype, and QAP 1.4, linked to DRB1*1301/02 haplotypes were also associated. Two mechanisms are suggested: the promoter polymorphisms may influence allele expression and thus the amount of peptides presented to the T-cell receptor, leading to a deficient CIR: HLA restriction is important for vaccine design; the way peptides anchor the DRB1*1501 groove may be relevant to the activation of TH1 cells, which contribute to an efficient presentation of peptides inducing a protective T-cell response.