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Objetivo: Avaliar o perfil e os fatores associados ao uso de anticoncepcionais orais combinados (AOC) em regimes de pausa (intermitente) ou estendido (contínuo) em mulheres férteis atendidas em um centro de planejamento familiar. Métodos: Trata-se de um estudo transversal, realizado no Centro de Pesquisa e Assistência em Reprodução Humana (CEPARH), Salvador, Bahia. Resultados: Entre julho e setembro de 2017, 210 mulheres atendidas, consecutivamente, no CEPARH foram entrevistadas. Dessas, 69 (32,8%) fazem uso de algum AOC, das quais 32 (46,4%) utilizam-no em regimes estendidos. Mulheres que trabalham têm 1,89 vezes mais chances de usarem AOC do que as que não trabalham (IC95%: 1,04-3,42; p=0,039). Nenhuma diferença significativa foi observada nas características entre as que fazem uso de AOC em regime de pausa ou estendido (p>0,05). Conclusão: Os resultados indicam que mulheres que trabalham adiam a concepção e utilizam com mais frequência a pílula contraceptiva, independentemente da forma de administração (forma contínua ou intermitente). Ademais, não há nenhum fator que contribua, significativamente, para que as mulheres façam uso estendido das cartelas de AOC.

Objective To evaluate the profile and factors associated with the use of combined oral contraceptives (COC) in pause (intermittent) or extended (continuous) regimens in fertile women attended at a family planning center. Methods: This is a cross-sectional study, carried out at the Center for Research and Assistance in Human Reproduction (CEPARH), Salvador, Bahia. Results: Between July and September 2017, 210 women consecutively attended at CEPARH were interviewed. Of these, 69 (32.8%) make use of some COC, of which 32 (46.4%) use it in extended regimens. Women who work were 1.89 times more likely to use COC than those who do not work (95%CI: 1.04-3.42; p=0.039). No significant difference was observed in characteristics among those who use COC in a paused or extended regime (p>0.05). Conclusion: The results indicate that working women postpone conception and use the contraceptive pill more frequently, regardless of the form of administration (continuous or intermittent). Moreover, there is no factor that contributes, significantly, for women to make extended use of COC cards.

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Introduction: This review aims to assess the available technologies, advances, and trends from technological readiness level 4 to level 8 for cancer immunologic therapeutics using the association of OX40 and CPG-ODN, usually known as cancer vaccine.Areas covered: Patent documents and clinic studies referring to the use of CpG-ODN and of OX40 association for cancer therapeutics. Patent data were obtained within the worldwide basis of the European Patent Office (EPO). The 138 patents of 36 patent families found were analyzed focusing on word distribution of technology developers and potential markets, legal status, annual evolution of first priority, technological domains, applicants and co-applicants and detailed analysis of each technology. Two clinical studies are in progress.Expert opinion: Traditional methods in post cancer diagnosis are being replaced by immunological association therapies. It is expected that the development of cancer vaccines will expand the scope of cancer-specific immunotherapy, especially if associated with alternative systems for expression and delivery with future potential. It is expected that genetic and controlled and/or specific nano delivery are improved. Furthermore, these new developments will likely address the problem of long-term treatments, reducing cancer mortality and reducing patient numbers worldwide.

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