RESUMO

Using a previously described technique, "in vitro" determinations were carried out for faecal fermentation (FF): basal faecal fermentation (BFF), i.e, only with faeces, with faeces and lactulose (LFF) and with faeces, lactulose and bismuth subsalicylate (BiLFF) in 34 patients with flatulence. The media+d.s. of the difference between the LFFand BFF levels (LFF-BFF) in patients with flatulence was significant and markedly higher than the respective media +d.s. in 30 normal control patients previously studied (9.1+4.7 vs. 3.9+3.2 ml gas/24 hrs; p<0.000001 respectively). And, although FF was reduced by adding bismuth salicylate in only 24% (70.6%) of the patients with flatulence but not in the remaining 10 (29.4%), in total the media+d.s. of the differences between the levels BiLFF and BFF (BiLFFBFF) was significantly lower that the media+d.s. of the differences between the LFF and BFF levels (LFF-BFF) (6.0+4.2 vs 9.1+4.7 ml gas/24 hrs; p<0.01 respectively). These results confirm that: 1) The fermentative capacity of the colonic bacteriae is most likely to be abnormally intense in peoples with flatulence and 2) Bismuth subsalicylate can be useful in the control of excessive colonic fermentation and flatulence; they raise, furthermore, the interesting possibility that we may have found the way to predict when the use of bismuth subsalicylate could be effective in the treatment of a patient with flatulence.

Assuntos

RESUMO

Empleando una técnica descrita previamente, se hicieron determinaciones "in vitro" de fermentación fecal (FF) basal (FFB), sólo con heces, también con heces y lactulosa (FFL), y con heces, lactulosa y subsalicilato de bismuto (FFLBi), en 34 pacientes con flatulencia. La media+d.s. de las diferencias entre los niveles de FFL y FFB (FFL-FFB) en los pacientes con flatulencia fue significativa y marcadamente mayor que la respectiva media+d.s. en 30 sujetos controles normales estudiados anteriormente (respectivamente, 9.1+4.7 vs. 3.9+3.2 ml de gas/24h; p menor que 0.000001). Y, aunque la FF disminuyó con la adición de subsalicilato de bismuto en sólo 24 (70.6 por ciento) de los pacientes con flatulencia pero no en los restantes 10 (29.4 por ciento), en total la media+d.s. de las diferencias entre los niveles de FFLBi y FFB (FFLBi-FFB) fue significativamente más baja que la media+d.s. de las diferencias entre los niveles de FFL y FFB (FFL-FFB) (respectivamente, 6.0+4.2 vs. 9.1+4.7 ml de gas/24h; p menor que 0.01). Estos resultados confirman que: 1) Muy probablemente, la capacidad fermentativa de las bacterias colónicas es anormalmente intensa en personas con flatulencia; y 2) El subsalicilato de bismuto puede ser de utilidad en el control de la fermentación colónica excesiva y la flatulencia; y, además sugieren la interesante posibilidad de que pudiéramos haber encontrado la forma de predecir cuándo el empleo del subsalicilato de bismuto va a ser efectivo en el tratamiento de un paciente con flatulencia.

Using a previously described technique, “in vitro” determinations were carried out for faecal fermentation (FF): basal faecal fermentation (BFF), i.e, only with faeces, with faeces and lactulose (LFF) and with faeces, lactulose and bismuth subsalicylate(BiLFF) in 34 patients with flatulence.The media+d.s. of the difference between the LFFand BFF levels (LFF-BFF) in patients with flatulence was significant and markedly higher than the respective media +d.s. in 30 normal control patients previously studied (9.1+4.7 vs. 3.9+3.2 ml gas/24 hrs;p<0.000001 respectively). And, although FF was reduced by adding bismuth salicylate in only 24 per cent (70.6 per cent) of the patients with flatulence but not in the remaining 10 (29.4 per cent), in total the media+d.s. of the differences between the levels BiLFF and BFF (BiLFFBFF) was significantly lower that the media+d.s. of the differences between the LFF and BFF levels (LFF-BFF) (6.0+4.2 vs 9.1+4.7 ml gas/24hrs; p<0.01 respectively). These results confirm that: 1) The fermentative capacity of the colonic bacteriae is most likely to be abnormally intense in peoples with flatulence and 2) Bismuth subsalicylate can be useful in the control of excessive colonic fermentation and flatulence; they raise, furthermore, the interesting possibility that we may have foundthe way to predict when the use of bismuth subsalicylate could be effective in the treatment of a patient with flatulence.

Assuntos

RESUMO

Determinations of the fecal fermentation in subjects may be very useful to know the fermentative capacity of his colonic bacteria. Determinations of basal fecal fermentation (FFB) and fecal fermentation with lactulose (FFL) were done in 30 normal subjects and 126 patients with flatulence, especially meteorism. The media +/- s.d. of FFB was significantly higher in the normal subjects than in the patients with flatulence (1.82 +/- 1.55 vs. 1.24 +/- 1.40 ml of gas/24 h; P: 0.015). On the contrary, in patients with flatulence the obtained media +/- s.d. of FFL and of the differences between FFL and FFB (FFL-FFB) were significantly and markedly higher than in the normal subjects (respectively: 8.84 +/- 5.55 vs. 5.72 +/- 3.72 ml of gas/24 h, P: 0.004; and 7.60 +/- 5.05 vs. 3.91 +/- 3.22 ml of gas/24 h, P<0.00001). The obtained results seem to indicate that patients with flatulence tend to have a colonic flora with high fermentative capacity.

Assuntos

RESUMO

Las determinaciones de fermentación fecal en una persona pueden ser muy útiles para conocer la capacidad fermentativa de sus bacterias colónicas. Se hicieron determinaciones de fermentación fecal basal (FFB) y con adición de lactulosa (FFL) en 30 sujetos normales y 126 pacientes con flatulencia, especialmente meteorismo. La media más menos d.s. de FFB fue significativamente algo mayor en los sujetos normales que en los pacientes con flatulencia (1.82 más menos 1.55 vs. 1.24 más menos 1.40 ml de gas/24 h; P:0.015). Por el contrario, en los pacientes con flatulencia se obtuvieron medias más menos d.s. de FFL y de las diferencias entre FFL y FFB (FFL-FFB) significativa y marcadamente mayores que en los sujetos normales (respectivamente: 8.84 más menos 5.55 vs. 5.72 más menos 3.72 ml de gas/24h, P:0.004); y 7.60 más menos 5.05 vs. 3.91 más menos 3.22 ml de gas/24 h, P menor 0.00001). Los resultados obtenidos parecerían indicar que pacientes con flatulencia tienden a tener una flora colónica con alta capacidad fermentativa.

Assuntos