RESUMO
The feeding behavior in fish is a complex activity that relies on the ability of the brain to integrate multiple signals to produce appropriate responses in terms of food intake, energy expenditure, and metabolic activity. Upon stress cues including viral infection or mediators such as the proinflammatory cytokines, prostaglandins, and cortisol, both Pomc and Npy/Agrp neurons from the hypothalamus are stimulated, thus triggering a response that controls both energy storage and expenditure. However, how appetite modulators or neuro-immune cues link pathogenesis and energy homeostasis in fish remains poorly understood. Here, we provide the first evidence of a molecular linkage between inflammation and food intake in Salmon salar. We show that in vivo viral challenge with infectious pancreatic necrosis virus (IPNV) impacts food consumption by activating anorexic genes such as mc4r, crf, and pomcb and 5-HT in the brain of S. salar. At the molecular level, viral infection induces an overall reduction in lipid content in the liver, favoring the production of AA and EPA associated with the increment of elovl2 gene. In addition, infection upregulates leptin signaling and inhibits insulin signaling. These changes are accompanied by a robust inflammatory response represented by the increment of Il-1b, Il-6, Tnfa, and Pge2 as well as an increased cortisol level in vivo. Thus, we propose a model in which hypothalamic neurons respond to inflammatory cytokines and stress-related molecules and interact with appetite induction/inhibition. These findings provide evidence of crosstalk between pathogenesis-driven inflammation and hypothalamic-pituitary-adrenocortical axes in stress-induced food intake behavior in fish.
Assuntos
Infecções por Birnaviridae , Comportamento Alimentar , Hipotálamo/metabolismo , Inflamação , Metabolismo dos Lipídeos , Salmo salar/fisiologia , Animais , Citocinas/imunologia , Citocinas/metabolismo , Hipotálamo/fisiologia , Vírus da Necrose Pancreática Infecciosa , Insulina/metabolismo , Leptina/metabolismo , Salmo salar/metabolismo , Salmo salar/virologia , Transdução de SinaisAssuntos
Humanos , Feminino , Gravidez , Pré-Eclâmpsia , Eclampsia , Anestesia , Hipertensão , Chile , AnestesiologiaRESUMO
Caroli disease is a cystic congenital malformation of the intrahepatic biliary tract, frequently associated with lithiasis. Commonly, cystic dilatations are bilateral and infrequently they affect only one hepatic lobule or segment. We report six patients with localized Caroli disease, three in the right and three in the left hepatic lobule, that were subjected to a hepatic resection. There were no postoperative complications or mortality. After 28 months of follow up, patients are asymptomatic and with normal hepatic function and ultrasonography. The importance of diagnosing localized Caroli disease, in which hepatic resection can be curative, is emphasized.
Assuntos
Doença de Caroli/cirurgia , Adulto , Idoso , Ductos Biliares Intra-Hepáticos/cirurgia , Doença de Caroli/diagnóstico por imagem , Colangiopancreatografia Retrógrada Endoscópica , Feminino , Seguimentos , Humanos , Fígado/cirurgia , Pessoa de Meia-Idade , Estudos Retrospectivos , Tomografia Computadorizada por Raios XAssuntos
Humanos , Feminino , Gravidez , Anestesia Obstétrica/métodos , Pré-Eclâmpsia , Trabalho de Parto , Síndrome HELLP/complicaçõesAssuntos
Humanos , Feminino , Neoplasias Urogenitais/diagnóstico , Neoplasias Urogenitais/tratamento farmacológico , Neoplasias Urogenitais/cirurgia , Neoplasias Renais/tratamento farmacológico , Neoplasias Renais/cirurgia , Neoplasias Pélvicas/tratamento farmacológico , Neoplasias Pélvicas/cirurgia , Neoplasias da Próstata/tratamento farmacológico , Neoplasias da Próstata/cirurgia , Neoplasias Testiculares/tratamento farmacológico , Neoplasias Testiculares/cirurgia , Neoplasias Ureterais/tratamento farmacológico , Neoplasias Ureterais/cirurgia , Procedimentos Cirúrgicos UrológicosRESUMO
Se relata la experiencia de anestesia en cirugía laparoscópica en ginecología en el Hospital J.J. Aguirre