RESUMO
BACKGROUND: Allergic rhinitis affects 20 million of people in United States and a higher figure all around the world. OBJECTIVE: To evaluate the efficacy and safety of fexofenadine compared with certirizine in the treatment of allergic rhinitis. MATERIAL AND METHOD: It was carried out a prospective, double blind, comparative, randomized and multicentric study in patients with allergic rhinitis, with ages between 12 and 65 years. In the first phase, placebo was administered during three days to all the patients; and then, they were randomly allocated to receive fexofenadine 120 mg or cetirizine 10 mg in one dose a day during 14 days. Laboratory and cabinet tests at the beginning and at the end were performed to value security, as well as a global evaluation of the researcher to estimate effectiveness. RESULTS: 176 patients were included, 63.6% were women, average age was 27 years (+/- 12), 47.7% received fexofenadine and 52.2%, cetirizine. There was not significant difference in parameters of effectiveness nor of security in the studied group. CONCLUSION: The results of the present study confirm the efficacy and safety of the antihistaminic fexofenadine in the treatment of allergic rhinitis.
Assuntos
Antialérgicos/uso terapêutico , Cetirizina/uso terapêutico , Antagonistas dos Receptores Histamínicos H1/uso terapêutico , Rinite Alérgica Perene/tratamento farmacológico , Rinite Alérgica Sazonal/tratamento farmacológico , Terfenadina/análogos & derivados , Terfenadina/uso terapêutico , Adolescente , Adulto , Idoso , Antialérgicos/efeitos adversos , Cetirizina/efeitos adversos , Criança , Método Duplo-Cego , Feminino , Antagonistas dos Receptores Histamínicos H1/efeitos adversos , Humanos , Masculino , Pessoa de Meia-Idade , Segurança , Índice de Gravidade de Doença , Terfenadina/efeitos adversos , Resultado do TratamentoAssuntos
Pirróis/metabolismo , Pesquisa , Anemia/tratamento farmacológico , Anemia/metabolismo , Animais , Substâncias de Crescimento/farmacologia , Hematopoese/efeitos dos fármacos , Hematopoese/fisiologia , Hemina/farmacologia , Hemina/uso terapêutico , Hemoglobinas/farmacologia , Humanos , Plantas/efeitos dos fármacos , Plantas/metabolismo , Pirróis/farmacologia , Ratos , Ratos Wistar , TetrapirróisRESUMO
PIP: 65 patients of gestational age 35.4 weeks, and of average age 27.7 were investigated during postpartum after delivery of stillborn babies, to measure hemoglobin, serum assay of iron, total iron binding capacity (TIBC), folates level, and vitamin B 12 level. Comparison with a series of 270 women in their third trimester of pregnancy showed that the first group of patients had lower mean hemoglobin level, lower serum iron level, lower TIBC, and lower serum folate level. There was no difference in transferrin saturation, and serum vitamin B 12 was higher. The percentage of anemic women was 50% versus 20% in the larger group; however, there was no difference in the prevalence of iron deficiency. There also was a direct correlation with B12 and serum folate. Further studies are needed to validate these findings.^ieng
Assuntos
Anemia Hipocrômica/sangue , Morte Fetal , Hemoglobinas/análise , Complicações Hematológicas na Gravidez/sangue , Adolescente , Adulto , Feminino , Idade Gestacional , Humanos , Idade Materna , México , Pessoa de Meia-Idade , Gravidez , Vitamina B 12/análiseRESUMO
PIP: This work analyzes the possible causes of anemia in 2 groups of pregnant women observed in 2 different hospitals in Mexico City; 1 group of 216 patients, and another group of 121 women who were already in labor. Women in the first group were short, of low schooling, high gestation and parity, and high incidence of previous fetal losses. Women in the second group were taller, slightly better educated, but still with high gestation and parity, and high incidence of fetal lossed. Hematological data collected included hemoglobin level, packed cell volume, RBC folates, serum assay of iron, total iron binding capacity, and albumin. 23% of patients in the first group, and 17% in the 2nd. group were found to be anemic; the percentage rose to 49% and 35% respectively if patients with low hemoglobin level were also considered to be anemic. The principal finding of the study was that iron deficiency was present in 53% of cases of anemia, and that it was probably to be ascribed to nutritional deficiencies.^ieng
Assuntos
Anemia Hipocrômica/sangue , Hemoglobinas/análise , Complicações Hematológicas na Gravidez/sangue , Feminino , Humanos , Ferro/sangue , GravidezRESUMO
The non-heme iron, folates, and vitamin B12 in the liver of 77 fetuses were assayed as were serum levels of these metabolites in 70 of their mothers. The findings indicate the existence of independent placental transport mechanisms, switched on and off at different stages of late gestation, and peculiar to each metabolite.