RESUMO
The industries are searching for greener alternatives for their productions due to the rising concern about the environment and creation of waste and by-products without industrial utility for that specific line of products. This investigation describes the development of two stable nanostructured lipid carriers (NLCs): one is the formulation of a standard NLC, and the other one is the same NLC formulation associated with a natural deep eutectic solvent (NaDES). The research presents the formulation paths of the NLCs through completeness, which encompass dynamic light scattering (DLS), zeta potential tests, and pH. Transmission electron microscopy (TEM) and confocal microscopy were performed to clarify the morphology. Cytotoxicity tests with zebrafish were realized, and the results are complementary to the in vitro outcomes reached with fibroblast L132 tests by the MTT technique and the zymography test. Infrared spectroscopy and X-ray diffractometry tests elucidated the link between the physicochemical characteristics of the formulation and its behavior and properties. Different cooling techniques were explored to prove the tailorable properties of the NLCs for any industrial applications. In conclusion, the compiled results show the successful formulation of new nanocarriers based on a sustainable, eco-friendly, and highly tailorable technology, which presents low cytotoxic potential.
RESUMO
This review discusses the significance of natural deep eutectic solvents (NaDESs) as a promising green extraction technology. It employs the consolidated meta-analytic approach theory methodology, using the Web of Science and Scopus databases to analyze 2091 articles as the basis of the review. This review explores NaDESs by examining their properties, challenges, and limitations. It underscores the broad applications of NaDESs, some of which remain unexplored, with a focus on their roles as solvents and preservatives. NaDESs' connections with nanocarriers and their use in the food, cosmetics, and pharmaceutical sectors are highlighted. This article suggests that biomimicry could inspire researchers to develop technologies that are less harmful to the human body by emulating natural processes. This approach challenges the notion that green science is inferior. This review presents numerous successful studies and applications of NaDESs, concluding that they represent a viable and promising avenue for research in the field of green chemistry.
RESUMO
Objetivos: desenvolver atividades meditativas com estudantes de uma universidade do noroeste gaúcho e analisar a percepção de estudantes universitários sobre a prática meditativa. Método: pesquisa-intervenção, de abordagem qualitativa. Realizaram-se 11 encontros para meditação, com participação de cinco estudantes, no período de abril a julho de 2019. Os dados produzidos mediante questionário com dados sociodemográficos e de saúde, observação não participante e entrevista aberta foram submetidos à análise temática. Resultados: a participação dos estudantes na meditação foi motivada pela curiosidade, dificuldade de concentração, estresse, irritação, ansiedade e nervosismo. A meditação mindfulness proporcionou aumento da concentração e foco para os estudos, melhorou a qualidade do sono e promoveu autoconhecimento e bem-estar subjetivo. Conclusão: a meditação mindfulness na Universidade foi importante à promoção da saúde mental, efetiva à minimização de estados de estresse e ansiedade e promoveu mudanças positivas na vida dos estudantes.
Objectives: to develop meditative activities with students from a university in northwestern Rio Grande do Sul and to analyze the perception of university students about meditative practice. Method: research-intervention, with a qualitative approach. We accomplished 11 meditation meetings, with the participation of five students, from April to July 2019. The data produced through a questionnaire with sociodemographic and health data, non-participant observation and open interview were subjected to thematic analysis. Results: students' participation in meditation was motivated by curiosity, difficulty concentrating, stress, irritation, anxiety and nervousness. Mindfulness meditation provided increased concentration and focus for studies, improved sleep quality and promoted self-awareness and subjective well-being. Conclusion: mindfulness meditation at the University was important to promote mental health, effective in minimizing stress and anxiety states and promoted positive changes in students' lives.
Objetivos: desarrollar actividades meditativas con estudiantes de una universidad del noroeste de Rio Grande do Sul y analizar la percepción de universitarios sobre la práctica meditativa. Método: investigación-intervención con enfoque cualitativo. Se realizaron 11 encuentros de meditación, con la participación de cinco estudiantes, entre abril y julio de 2019. Los datos producidos mediante un cuestionario con datos sociodemográficos y sanitarios, observación no participante y entrevista abierta se sometieron al análisis temático. Resultados: la participación de los estudiantes en la meditación estuvo motivada por la curiosidad, dificultad para concentrarse, estrés, irritación, ansiedad y nerviosismo. La meditación mindfulness proporcionó una mayor concentración y enfoque para los estudios, mejoró la calidad del sueño y promovió la autoconciencia y el bienestar subjetivo. Conclusión: la meditación mindfulness en la Universidad fue importante para promover la salud mental, eficaz para minimizar los estados de estrés y ansiedad y promovió cambios positivos en la vida de los estudiantes.