RESUMO
Multifocal papilloma virus epithelial hyperplasia is an infection of the oral mucosa produced by human papilloma virus types 13 and 32, which primarily bilaterally affects lips, lateral borders of tongue, and buccal mucosa. The attached oral mucosa, floor of mouth, soft palate, and oropharynx are sites that appear not to be affected. This study comprises 110 patients with multifocal papilloma virus epithelial hyperplasia identified over a period of 3 years in Guatemala City and neighboring rural areas. All but four patients were younger than 18 years of age. More than one affected patient was observed in several families. All but three cases occurred in patients living in extreme poverty (annual family income less than $1,200 in U.S. dollars). Biopsies of 60 lesions demonstrated acanthosis and nuclear degeneration within the epithelium. We suggest that the eponym Heck's disease be abandoned because this disease was described in the Latin-American literature before the initial description in the American literature. We propose the term multifocal papilloma virus epithelial hyperplasia, which best describes the nature and multifocality of this disease.
Assuntos
Hiperplasia Epitelial Focal/microbiologia , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/epidemiologia , Infecções Tumorais por Vírus/epidemiologia , Adolescente , Adulto , Distribuição por Idade , Criança , Pré-Escolar , Saúde da Família , Feminino , Hiperplasia Epitelial Focal/epidemiologia , Hiperplasia Epitelial Focal/patologia , Guatemala/epidemiologia , Humanos , Masculino , Pobreza , Distribuição por Sexo , Razão de Masculinidade , Terminologia como AssuntoRESUMO
Five types of oculocutaneous albinism and two types of ocular albinism were found among 349 Puerto Rican albinos. The most prevalent type of albinism was the Hermansky-Pudlak syndrome (HPS). HPS was observed in five of every six albinos in Puerto Rico. The prevalence of HPS was highest in the northwestern quarter of the island, affecting approximately one in 1,800 persons, and approximately one in 22 are carriers of the gene. HPS is an autosomal recessively inherited triad of a tyrosinase-positive type of albinism, a hemorrhagic diathesis due to storage pool deficient platelets and accumulation of ceroid in tissues. The pigmentary phenotype of HPS albinos resembled that of any other type of oculocutaneous or ocular albinism. The most reliable method of diagnosing HPS is by a deficiency of platelet dense bodies observed by electron microscopy. The accumulation of ceroid in the tissues is associated with fibrotic restrictive lung disease and granulomatous enteropathic disease. The enteropathic disorder resembles Crohn's disease and with few exceptions, had its onset after 13 years of age. The major causes of death were fibrotic restrictive pulmonary disease, hemorrhagic episodes and sequelae of granulomatous enteropathic disease. Menometrorrhagia was common in women with HPS. No immune deficiency was found in HPS patients. The majority of patients with HPS had visual acuities of 20/200 or worse and consequently were legally blind. Albinos of all types, including HPS, lacked binocular vision due to nearly complete crossing of the optic tracts.
Assuntos
Albinismo Ocular/epidemiologia , Albinismo Oculocutâneo/epidemiologia , Albinismo Oculocutâneo/complicações , Albinismo Oculocutâneo/genética , Transtornos Plaquetários/etiologia , Causas de Morte , Estudos Transversais , Humanos , Porto Rico/epidemiologiaRESUMO
A total of 32,022 Mexican children (16,473 boys, 15,549 girls) were examined for several congenital oral and paraoral anomalies. The findings for commissural lip pits (boys 53.1, girls 52.4 per 1000) are less than those reported for adults. This may indicate that pits become accentuated with age. Fordyce granules were seen with a prevalence of 1.2 per 1000. This is in contrast to the reported 85.6% prevalence for the adult population, also possibly reflecting increased manifestation with increased age. Our data for exogenous tooth pigmentation show increased prevalence with age (group I [5 to 10 1/2 years], 9.8%, versus group II [10 1/2 to 14 1/2 years], 12.9%), possibly indicating decrease in attention to oral hygiene. The prevalence of talon cusp was found to be 0.6 per 1000, and for ankyloglossia 8.3 per 1000. Prevalence values for bifid tongue are reported for the first time, indicating one affected per 187 children examined. The prevalence of fissured tongue (15.7%) shows a statistically significant difference between boys (16.8%) and girls (14.5%). The prevalence of geographic tongue (1.9%) shows a marked difference between group I (2.2%) and group II (1.2%).
Assuntos
Anormalidades da Boca/epidemiologia , Anormalidades Dentárias/epidemiologia , Adolescente , Criança , Pré-Escolar , Fissura Palatina/epidemiologia , Estudos Transversais , Feminino , Humanos , Lábio/anormalidades , Doenças Labiais/epidemiologia , Masculino , México , Língua/anormalidades , Doenças da Língua/epidemiologiaAssuntos
Doenças da Boca , Anormalidades Dentárias , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Boca/lesões , Neoplasias BucaisRESUMO
An apparently new disorder of enamel is briefly described.
Assuntos
Esmalte Dentário/anormalidades , Adolescente , Argentina , Criança , Humanos , Masculino , Doenças Dentárias/diagnósticoRESUMO
A total of 6,180 Argentinian school-age children were examined clinically for the presence of oral congenital anomalies. The following prevalence figures were found: commissured lip pits (0.7%), ankyloglossia (0.1%), geographic tongue (1.5%), localized enamel hypomaturation (2.8%), median rhomboid glossitis (0.10/00), torus palatinus (0.30/00) and dentinogenesis imperfecta (0.30/00). Data are presented for the first time on snowcap amelogenesis imperfecta with a prevalence value of 0.1%.